How can we find novel natural products from Actinomycetes that act as growth modulators on mammalian cells? Can we harvest and develop the potential of these novel compounds for industrial and medical biotechnology?

Can light-activatable ruthenium compounds be used as a more selective anticancer treatment?

In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Promotores: J. Jonkers, K.E. de Visser

Cancer is the leading cause of death in the Netherlands, and, with over 100 different types of cancer, it’s not a simple disease. Today, skin, breast, lung, prostate and colon cancer are the most diagnosed forms. Therefore, the discovery and development of new drugs has the ability to significantly…

Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.

Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…

How can zebrafish research help to understand and fight human cancer?

Promotor: Prof.dr. R. Verpoorte, , Co-Promotor: Young Hae Choi

Researchers of the Leiden University Medical Centre (LUMC) and the Leiden Institute of Chemistry have made an important discovery about the commonly used anti-cancer drug doxorubicin. They have found a way to reduce its side effects without sacrificing the effectiveness of the medication. This is encouraging…

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar-Jagalska

A full overview of MCBIM PhD theses.

Former masterstudent Bio-Pharmaceutical Sciences Maddalena Centanni will be awarded the 2020 Arenberg Coimbra Prize for Erasmus Students. Centanni spent her six month Erasmus exchange at Uppsala Universiy in Sweden where she looked for ways to improve anti-cancer drug dosing.

On the 22nd of January 2016 the article: 'Drie valkuilen en denkfouten in de drang naar een kleinere overheid' (translation from Dutch: 'Three pitfalls and fallacies in the desire for a smaller government') written by prof. dr. Frits M. van der Meer & Mr. dr. G.S.A. Dijkstra was posted on Mejudice:…

Providing each cancer patient with the right treatment remains a challenge. Oncode Accelerator aims to change this by innovating the way we develop cancer treatments, thus ensuring the patient is at the heart of the process. Leiden University, the LUMC and other partners will implement this new way…

Last year, chemists Dennis Wander and Hermen Overkleeft contributed to an important discovery about a widely used cancer drug. Their research has now been recognised as Finalist for the PNAS Cozzarelli Prize in the Biomedical Sciences class.

De menselijke geschiedenis strekt zich ver uit vóór de tijd waarin de mensen opschreven wat er zoal gebeurde.

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

How can new compounds relieve cancer patients of severe side effects?

On the 3rd of April, Sebastiaan van der Lubben successfully defended a doctoral thesis. The Leiden University Centre for Linguistics congratulates Sebastiaan on this achievement!

Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.

Researchers from Leiden University Medical Center (LUMC) and Netherlands Cancer Institute (NKI) have discovered how specialised immune cells can detect and remove cancers that are ‘invisible’ to the conventional defence mechanisms of the immune system. Their work has been published in Nature. The findings…

PhD defence

Een samenwerking tussen het Leids Universitair Medische Centrum (LUMC), de Universiteit Leiden en Philips ontvangt financiering van wetenschapsfinancier NWO om MRI-scans te versnellen. Deze drie partijen vormen samen een van de 17 AI-labs die onder de naam ROBUST voor een periode van 10 jaar NWO-steun…

De positie van kunst en kunstenaars in de westerse samenleving

PhD defence

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

Leiden PhD student Xuequan Zhou has designed a new promising molecule that efficiently kills cancer cells, but does not harm healthy tissue. The trick: the drug is only active when irradiated with light. Zhou’s new compound does this extra efficiently by cleverly self-organising into nanoparticles.…

Lecture

Chemotherapy that does not harm the body, but effectively fights cancer cells: that is the goal of chemist Sylvestre Bonnet and his team. During his PhD research, chemist Xuequan Zhou brought that goal a little closer. He developed molecules that, upon injection in the bloodstream, self-assemble into…

Kralen spreken tot de verbeelding. Ze zijn aantrekkelijk en persoonlijk vanwege hun kleuren, materialen, patronen en associaties. Je draagt ze op je lichaam, waar je ze voelt en anderen ze zien. Kralen zijn waardevol en verplaatsbaar, tegelijkertijd reizigers en souvenirs.

Een scheepswrak, zijn bemanning en het leven in de 18de eeuw

PhD defence

How do macrophages and neutrophils contribute to metastatic onset?

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Promotor: G.P. van Wezel

Animal Sciences’ contribution to the Bioactive Molecules research theme includes research on molecules from natural sources, such as plants, insects, and snake venom, with the aim to identify novel anti-cancer, anti-inflammatory, anti-microbial, and anti-diabetic agents.

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

HZ Kenniscentrum Zeeuwse Samenleving doet op vraag van regionale overheden en maatschappelijke organisaties onderzoek naar actuele en maatschappelijke thema’s in de provincie Zeeland. De uitkomsten van onderzoeken en analyses worden gebruikt voor kennisopbouw en als basis voor beleidsopbouw en -ontwikkeling.…

Training and Exercising in Crisis management and Emergency Control

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

In films kunnen de meest wonderlijke acties plaatsvinden. Maar zijn die acties in de 'echte' wereld ook mogelijk? En in hoeverre houden filmmakers ons voor de gek? Tijdens het Leiden International Film Festival komen film en wetenschap samen.

Why are not all children equally responsive to variations in the social environment?

Eine Archäobotanische untersuchung zu Umwelt und Landwirtschaft der Ältesten Bankkeramik.

Leiden has much to celebrate: first, 450 years of the Relief of Leiden and then 450 years of Leiden University. And that is no coincidence.