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We have recently discovered that there are biological proteins that phase separate out of solution much the way oil will de-mix from water (see movie). These form dense, liquid-like phases called protein condensates.

Research at the Catalysis and Surface Chemistry group is comprised of the following research themes:

Research at the MCBIM group is comprised of the following research themes:

The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.

A group of biology students are working on a solution to the world’s plastics problem by getting bacteria to make biodegradable plastic.

Medicines do not follow the one size fits all principle, because genetic differences can influence their efficiency. That is what research by PhD candidate Julia Hillger shows. She defends her PhD dissertation Take it Personal on Thursday 7 December.

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Science, Institute of Environmental Sciences (CML)

PhD defence

PhD defence

PhD defence

PhD defence

In the future, physicians may be able to identify dementia much earlier than they can today because a computer algorithm will be able to predict from brain scans how our memory is going to develop.

What is the role of auxin in the initiation and process of somatic embryogenesis?

At the division of Biopharmaceutics, we aim to develop and test new therapeutic approaches to limit or even prevent the development of atherosclerosis in order to reduce the number of acute cardiovascular syndromes such as myocardial infarction or stroke.

What distinguishes a tumour cell from a healthy cell? Researchers are trying to answer this question as precisely as possible. Certain differences could eventually lead to new therapies.

The research programme Probability Theory focuses on probability theory and on operations research.

We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.

Research lines within the Pharmacy group:

Research aims: Identification of key genes involved in programming the cellular architecture of A. niger & Genetic engineering of A. niger in order to improve its secretory capacities and rheological behavior under industrial fermentation conditions.

How do macrophages and neutrophils contribute to metastatic onset?

Some people are predisposed to develop cancer. Mutations in genetic material that increase a person’s chances of developing cancer can already be present at birth. Researchers are closely examining these mutations to learn more about how cancer begins to develop.

The programme of the 3rd International Workshop on Klinefelter Syndrome, Trisomy X, and XYY. International Workshop theme: 'A life-course perspective'

Can we bring novel treatment options to the clinic for UM patients with liver metastases?

How can zebrafish research help to understand and fight human cancer?

PBDL favors multidisciplinary research. Depending on the problems under investigation, PBDL establishes collaborations between experts from for example molecular genetics, molecular and electro cell physiology, biochemistry, organic chemistry, analytical mathematics, mathematical statistics and computational…

The recognition that there may be more, so-called allosteric binding sites on a given receptor has also fueled our synthetic efforts. Over the last few years we have focused on many drug targets (adenosine A1, A2A and A3 receptors, the mGlu2 receptor and a classic ‘anti-target’, the hERG channel) to…

Alfons Chorus was the ‘founding father’ of Psychology in Leiden. His son Rogier Chorus recently obtained his PhD at Leiden University based on his biography of his father. He talked to his Leiden PhD supervisor Willem Heiser about his father’s innovations, his plagiarism and how he was misunderstood…

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

This project develops a scientific method to extract clinically relevant new information from patient forum websites that discuss patient experiences concerning e.g. medication, nutrition, co-morbidities, genetic factors etc.

Psycho-physiological reactions to stress.

Do large deletions represent a risk during CRISP/CAS9-mediated genome editing in plants?

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

Many researchers of the Faculty of Science are members of a research school related to their area of expertise. Research schools aim at collaboration of researchers from different faculties in the same university (interfaculty schools) or in different universities (interuniversity schools).

Promotores: A.H. Meijer, H.P. Spaink

Promotor: Prof.dr. E.F. Smets, Co-promotores: Dr. B. Gravendeel, F. Pupulin

The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…

What is the role of neuronal emotional reactivity in the intergenerational transmission of abuse?

Aim of the proposal is to develop lugdunomycin into a drug candidate able to treat infectious diseases caused by multi-drug resistant pathogens.

Promotor: Roeland M.H. Merks

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

The Plant BioDynamics Lab (PBDL) is a laboratory dedicated to experiments designed to develop and validate quantitative mathematical models of dynamical processes in biology. The principal objective of developing these models is to make quantitative predictions about these processes.

How can we culture an artificial vascular network to support tissue development ex vivo?

The group Clinical Neurodevelopmental Sciences has expertise in individual differences in child development, in particular the development of psychopathology, ranging from mild to severe neurodevelopmental disorders.

Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

How do cognitive, motivational, and affective processes interact to select actions?