700 search results for “soil barrier repair” in the Public website
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New paper on: 'Legal Barriers and Enablers to Big Data Reuse: A Critical Assessment of the Challenges for the EU Law'
eLaw colleagues Bart Custers and Helena Ursic have a new publication in the peer-reviewed journal The European Data Protection Law Review.
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Ecologist Emilia Hannula receives Gold Medal in Teylers Museum
Soil ecologists Emilia Hannula (Leiden) and Elly Morriën (UvA) received the Golden Medal of Teylers Tweede Genootschap on 5 November. They received the prize for their submission to a competition on sustainable soil management.
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Skin Lipids: Localization of Ceramide and Fatty Acid in the Unit Cell of the Long Periodicity Phase
The lipid matrix of the skin's stratum corneum plays a key role in the barrier function, which protects the body from desiccation. The lipids that make up this matrix consist of ceramides, cholesterol, and free fatty acids, and can form two coexisting crystalline lamellar phases: the long periodicity…
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A fatty solution for eczema
Pharmacologist Walter Boiten developed a new method to determine the amount of lipids in a person's skin. With this method he tested the effects of a new cream he developed for eczema patients. The first results are promising. Boiten defends his dissertation on 15 January.
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Break-through in the genetic modification of plants
A collaboration between the IBL and LUMC has resulted in the discovery that the polymerase theta enzyme is essential for the integration of Agrobacterium T-DNA into the genome of plants. The finding means a break-through for the development of more efficient systems for targeted genome modification…
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Soils2Guts
Steering soil microbiomes for better crop quality: the holy grail to improve human health?
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Quantitative modelling of the response of earthworms to metals
Promotor: Prof.dr. W.J.G.M. Peijnenburg, Co-promotor: Dr. ing. M.G. Vijver
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Vascular and Regenerative medicine
With an ageing population it is becoming increasingly important to find means to repair cells, tissue and organs through regenerative medicine.
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Fate, accumulation and impact of metallic nanomaterials in the terrestrial environment
The rapidly increasing commercial application of metallic nanoparticles within products will inevitably enhance the amount of NPs being released into soil.
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Understanding plant transgenesis
How is Pol θ responsible for T-DNA integration, and how do other DNA double-strand break repair pathways interact with Pol θ? How may we manipulate T-DNA integration to stimulate error-free integration at a predetermined genomic site?
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Enhancing epicardial EMT to repair the heart
PhD defence
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High fidelity DNA replication and repair
PhD defence
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Even plants can have neighbour trouble
Restoring a natural plant environment on exhausted agricultural lands and in nature areas is difficult. We can speed this up by steering the soils towards the desired situation. This is what Martijn Bezemer, newly appointed Professor of Ecology of Plant-Microbe-Insect interactions at Leiden University’s…
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Efficient gene-targeting during meiosis
Efficient gene-targeting during meiosis
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Participate
Wanted for the Re-pair study!
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Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…
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Effect of Nanoparticles on Microbial Catabolism and Community Structure using Biolog techniques
1. To what extent do metallic NPs added to soil extractions change the activity, abundance, or community composition of microbes? 2. How do the effects of metallic NPs on soil microbes differ from the effects of the ions shedding from corresponding NPs?
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Understanding the role of mycorrhizas in global carbon cycle processes
How the global distribution of vegetation stands dominated by arbuscular and ectomycorrhizal plants relate to principle aspects of belowground carbon accumulation processes?
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Riccardo Mancinelli
Science
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Chenguang Gao
Science
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Pengxuan Xie
Science
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Barrier Free Studying Lunch Meeting
Lecture
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Vascular and Regenerative Medicine
Methods of treatment for chronic illnesses are limited. Doctors and researchers at Leiden University Medical Center (LUMC) and Leiden University are working on new therapies as an alternative for organ transplants. The goal is to cure the illnesses by restoring organs to their original function. Stem…
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Natural Resources and Spatial Structure at Dzehkabtún, Mexico
This projects investigates spatial relations between soils and other resources and the urban layout of a classic Maya center in Campeche, Mexico.
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Impact of plant domestication on spermosphere and rhizosphere microbiome composition
Microbiome composition of the spermosphere and the rhizosphere of wild and modern bean accessions grown in an agricultural and a native soil from Colombia was characterized by metagenomics and cultivation-dependent approaches.
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Human skin equivalents: understanding the lipid biosynthesis in the skin
There is considerable need for improved skin models to develop safe and efficient drugs for skin delivery as well as for cosmetic and chemical product testing on the skin.
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Systems dermatology of inflammatory diseases
Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…
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Human epidermal lipid biosynthesis in health and disease
How are the epidermal lipid pathways involved in health and disease.
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Systems dermatology of immune-mediated dermatological diseases: cutaneous T-cell lymphoma
The complex pathophysiology of immuno-dermatological disorders is multifactorial, including environmental, skin microbiome, (epi)genetic and immune dysregulation conditions. This project primarily focuses on the orphan disease mycosis fungoides, a subtype of cutaneous T-cell lymphoma. The current pathophysiological…
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Exposure and health Assessment of Persistent Organic Pollutants (POPs) at e-waste recycling site among workers in the informal sector in Nigeria
Do e-waste workers display enhanced effects of adverse health effects due to informal e-waste processing in Nigeria? Is there a difference between the health outcomes of the exposed and the control groups? Are there difference in health effects within and between job groups (collectors, dismantlers,…
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
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Fungi of the greening Arctic: compositional and functional shifts in response to climatic changes
Promotor: E.F. Smets Co-promotor: J. Geml
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Volatile compounds from Actinobacteria as mediators of microbial interactions
Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.
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Peeking into the future: Fungi in the greening Arctic
Promotor: E.F. Smets, Co-promotor: J. Geml
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The Ecology and Evolution of Microbial Warfare in Streptomyces
The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.
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Peter van Bodegom
Science
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Microbial hitchhiking
How do nonmotile microbes leverage communal motility?
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Carbon atom reactivity with amorphous solid water: H2O-catalyzed formation of H2CO
We report new computational and experimental evidence of an efficient and astrochemically relevant formation route to formaldehyde (H2CO). This simplest carbonylic compound is central to the formation of complex organics in cold interstellar clouds and is generally regarded to be formed by the hydrogenation…
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Huygens
Niels Bohrweg 2, Leiden
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Nano shapes micro : Impacts of metallic nanoparticles on microbial communities
This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.
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Agrobacterium-mediated protein therapy for genome editing
Is translocation of nucleases possible via Agrobacterium T4SS and is it efficient enough for mutagenesis?
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Environmental and health impact of informal e-waste recycling
The majority (80%) of e-waste generated globally are recycled informally in developing countries.
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Unravelling molecular mechanisms in transcription-coupled nucleotide excision repair
PhD defence
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Nucleotide excision repair: from molecular mechanisms to patiënt phenotypes
PhD defence
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Control of replication associated DNA damage responses by Mismatch Repair
PhD defence
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Tineke Berkers has won an award
Tineke Berkers has won an award for outstanding contribution for her poster at the Gordon Research Conference at Waterville Valley, USA.
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Cancer and heredity
Some people are predisposed to develop cancer. Mutations in genetic material that increase a person’s chances of developing cancer can already be present at birth. Researchers are closely examining these mutations to learn more about how cancer begins to develop.
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New antibiotics
Pathogenic bacteria are increasingly resistant to today’s antibiotics. Professor Gilles van Wezel seeks new forms of antibiotics in good bacteria that live in the soil.
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TERRA: TERraced landscape of RAmosch, Switzerland
This project investigates the well-preserved agricultural terraces of the Inn valley and the evolution of resource use in the inner Alps.
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Morphogenesis and heterogeneity in liquid-grown streptomyces cultures
The filamentous bacteria Streptomyces are widespread inhabitants of terrestrial soils.