2,036 search results for “disease prevention” in the Public website
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Influencing your health with your behaviour and thoughts
Psychological processes have a major effect on the course of a disease and the effects of medical treatment. Researchers in the field of Psychoneurobiology examine the interactions between body and mind. They investigate the effects of stress as well as the effect of placebos and nocebos, which can…
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Inkomen en afkomst zijn risicofactoren bij kans op hart- en vaatziekten
Nederlanders met lage inkomens lopen tot 1,5 keer meer risico op het krijgen van een hartaanval of beroerte dan rijkere landgenoten. Bij Surinaamse Hindoestanen is dit risico 1,9 keer hoger. Dat blijkt uit onderzoek van het LUMC en het HagaZiekenhuis. Nederlandse artsen kijken tot nu toe niet naar deze…
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The quest for new medicines against tuberculosis
Can drug screening for tuberculosis treatment be made more efficient?
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Conquering the fortress: New strategies for the treatment of tuberculosis
Can we exploit the cell death machinery of the host to develop new host-directed anti-TB treatments?
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Portraits Johan Kuiper and Ilze Bot on Hartstichting.nl
The Heart Foundation has portrayed researchers Johan Kuiper and Ilze Bot of the Leiden Academic Centre for Drug Research (LACDR) who fight heart and brain infarcts in the lab.
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Topic: Stigmatization in patients with chronic health conditions
Imagine that you have a chronic skin condition, characterized by red patches of itchy, scaly skin. You regularly notice people staring at your skin and sense their reluctance to shake your hand. Or imagine that you have Parkinson's Disease, causing your hands to tremble and making it difficult for you…
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Polar auxin transport: translating environmental signals into plant developmental responses
1. What is the exact role of PIN proteins in PAT? 2. How is PIN polarity established, and how is it modulated by AGC kinase-mediated phosphorylation? 3. What is the role of the AGC kinase, as modulators of PAT, in translating environmental signals, such as gravity, light or mechanical stress, to plant…
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Life Science & Technology (MSc)
Increased molecular knowledge of the mechanisms of processes in the cell can lead to better medicines or new methods for combating diseases. Our MSc students in Life Science and Technology (LST) specifically learn to understand the molecular and structural chemical and biological aspects of disease-related…
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Talk and debate: how do we prevent science from harming the environment?
Sustainability researchers can play an important role in the energy transition. But what if their partners are not (yet) sustainable and science itself has adverse effects? This is the subject of an online talk by researcher Thomas Franssen on 16 December with a discussion afterwards. ‘Clean energy…
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Programme structure
The master's specialisation Clinical Psychology consists of three main parts: the mandatory and elective courses, a thesis and an internship.
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Systematic investigations into the role of ceramide subclass composition on lipid organization and skin barrier
The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.
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We all BENEFIT: The Ecosystem for Healthy Living
The modification of risk factors and related health behaviors lies at the very core of adequate cardiovascular risk management, yet evidence shows that the majority of people with cardiovascular disease (CVD) fail to achieve a healthy lifestyle in the long term. The main objective of this project is…
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Research projects
The research of the Van Eck Group focusses on 3 interconnected research lines: 1) Identification and therapeutic targeting of key pathways/regulators in macrophages essential for prevention of atherosclerotic lesion development or stimulation of regression of existing lesions, 2) Atherosclerosis as…
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Linking aboveground-belowground interactions and plant-soil feedback to improve pest control and sustainability in greenhouse cut-flowers
We examine how soil inoculation influences aboveground organisms (i) directly, and indirectly via (ii) its effects on plant chemistry or volatile emission, or via (iii) mediating the effects of belowground pathogens on aboveground organisms via the shared plant.
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Imaging of biomaterial-associated inflammation and infection using zebrafish
Which immune mechanisms are involved in host defense against Staphylococcal infection?
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Course content
The Master’s programme Health, Ageing and Society trains its students to become academic Health, Ageing and Society professionals and engaged citizens who are competent and trained internationally and interdisciplinary. They are able to contribute to solutions for the challenges facing our ageing so…
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Inhibiting protein production potentially a weapon against Alzheimer’s
Inhibiting specific protein production in the human body can serve as a crucial weapon in the fight against Alzheimer's, Eline van Maanen believes. PhD defence 23 November.
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Africa reconsidered
If you follow the western media, you are likely to think of ‘Africa’ as the continent of origin of desperate migrants, a continent of hunger and disease and a breeding ground for international terrorism. But if you want to see the bigger picture, you should look no further than the African Studies scholars…
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More effective blocking of CCR2 receptor
The discovery of new medicines is a tedious and lengthy process. On average, over 10,000 molecules need to be studied for one to become a drug and reach the patient. Part of that process are the very costly clinical trials in humans, and candidate drugs often fail due to side effects or lack of efficacy.…
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New Methods for (f)MRI Analysis
Analysis of neuroimaging data requires multiple steps where statistics play a crucial role. The MRI methods research group develops new statistical methods that are accurate, transparent and easy to use.
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Development of new antibiotics from plant-originated products
Utilization of plant-originated products as new antibiotics
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Understanding plant transgenesis
How is Pol θ responsible for T-DNA integration, and how do other DNA double-strand break repair pathways interact with Pol θ? How may we manipulate T-DNA integration to stimulate error-free integration at a predetermined genomic site?
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Role of Chemokine Gradient Sensing in Ewing Sarcoma Progression, Angiogenesis and Immune Targeting
What are the biological and biophysical mechanisms that control chemokine gradient sensing and migration of immune, endothelial, and tumour cells in tumour development?
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Archaeology of the Lower Maroni River
The application of compliance archaeology techniques such as mechanical large scale excavations where large quantities of data are gathered in relatively little time (and relatively inexpensively) and a firm post-excavation research phase yielded a whole new body of archaeological evidence.
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Knowledge of DNA repair in the fight against tumour cells
What is the most effective way to eliminate tumour cells? The DNA repair mechanism could play an important role in increasing the effectiveness of chemotherapy in the fight against cancerous cells. If we are to influence this mechanism, we need fundamental knowledge about how the mechanism works.
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The Dutch Network Science Society Symposium 2022 was a success
Back after pandemic interruptions, the Dutch Network Science Society Symposium took place on May 19th, 2022. The event brought together researchers from around The Netherlands studying complex networks and representing various disciplines, including mathematics, physics, neuroscience, computer science,…
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Cool little kids
Effectiveness of an early intervention program for anxiety-prone toddlers in the Netherlands
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Innate immune defence against intracellular pathogens
What are the host immune defence mechanisms that control intracellular infections and how are these subverted by pathogens?
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R-ELEVATION
How do plant defense genes get activated?
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Biological and Soft Matter Physics
Research groups in the Biological & Soft Matter Programme unravel mechanisms in biological processes and develop novel bio-inspired soft materials.
- Event: Preventing Future Ukraines
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Teaching
Research projects for students of the University of Leiden and other Dutch Universities are often available at the MacBio group. The research lines are also described in the Research section. For details of specific projects contact the supervisor (Ubbink, Dame, Boyle, Jeuken or Wentink).
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Paul Hooykaas
Science
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Herman Spaink
Science
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Veronique de Gucht
Faculteit der Sociale Wetenschappen
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PhD candidates in their own words
The Data Science Research Programme at Leiden University combines data science with PhD projects in a wide range of disciplines. The programme has been running for over two years, and is producing the first astonishing results. A number of PhD candidates talk about their experiences and research bel…
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Ageing
As a result of an increased life expectancy, more people suffer from chronic diseases and discomfort. Elderly patients may have multiple diseases simultaneously, with concomitant multiple medications.
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Cholesterol metabolism and hematopoiesis interaction in atherothrombosis
Cardiovascular disease is the leading cause of death worldwide.
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Lessons from Rare Diseases
PhD defence
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Overview
The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterise and predict variation in treatment response and enhance translational drug development strategies.
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Why don't drugs make it to the market?
How can we extend the drug residence time to combat diseases more effectively?
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Vertebrate automated screening technology (VAST)
How can you use robots and automatic recognition of microscopic images to test the effect of drugs exceptionally quickly?
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Azafaros is valorizing a library of compounds
The company Azafaros was established in 2018 to translate innovative science from Leiden University and Amsterdam University Medical Center into novel disease-modifying treatment modalities for rare genetic metabolic disorders such as lysosomal storage diseases.
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Chemical biology of sphingolipids: fundamental studies and clinical applications
Overkleeft
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CoSTREAM: Understanding Stroke and Alzheimer
The Horizon 2020 project CoSTREAM aims to improve our understanding of the co-occurrence of stroke and Alzheimer’s disease. It has long been known that both diseases share underlying causes, but their exact interaction or link is not fully understood. CoSTREAM combines multiple factors to identify and…
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Analytical chemistry and biochemistry of glycosphingolipids: new developments and insights
Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…
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Rational Design of Athero-Protective Vaccines; Novel Vaccine Formulations and Alternative Routes of Administration
Atherosclerosis is a chronic inflammatory disease affecting millions of people world-wide.
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Dr. Kiefte-de Jong and Dr. Bosker, Assistant Professors at LUC, both awarded LUF Awards
Dr. Jessica Kiefte-de Jong and Dr. Thijs Bosker, both Assistant Professors at LUC, have been awarded by The Leiden University Fund (LUF).
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Research
Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…
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Nose of E. coli zips open and shut
PhD student Wen Yang discovered how certain cell receptors in E. coli bacteria signal 'smells'. With the use of ice-cold electron microscopy microbiologists from Leiden gain more insight into how bacteria respond to their environment. Publication in mBio.