1,005 search results for “brain function and dysfunction” in the Public website
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Vici grant for Bernet Elzinga
Bernet Elzinga (Clinical Psychology) is one of the seven scientists from the Leiden University who has received a Vici grant of 1.5 million euros from NWO. Vici is one of the largest grants for individual scientists in the Netherlands. The funding will enable her to do research for the next five years…
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Functional characterization and unraveling the Gene Regulatory Networks (GRNs) of HD-Zip transcription factor HB40 (and HB22) in Arabidopsis
In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.
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Julie Hall
Faculteit der Sociale Wetenschappen
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Rebecca Schaefer
Faculteit der Sociale Wetenschappen
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Hanneke Leegwater
Science
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Dominik Sieh
Faculteit der Sociale Wetenschappen
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Ilse Schuitema
Faculteit der Sociale Wetenschappen
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Kaixuan Pan
Science
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Cannabis makes you less alert
Regular users of cannabis are less aware of their own mistakes, and they are not good at creative thinking. This is the conclusion drawn by psychologist Mikael Kowal from his research on the effects of cannabis. PhD defence 6 October.
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Fungi of the greening Arctic: compositional and functional shifts in response to climatic changes
Promotor: E.F. Smets Co-promotor: J. Geml
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The mechanical genome : inquiries into the mechanical function of genetic information
The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.
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In vitro and in vivo delivery of functionalized nanoparticles via coiled-coil interactions
Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn
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ARCHITECTURES OF SPEED - reinventing the tools, functions and potentials of speed within rhythmical frames in music
What are the precise identities, possibilities and current practice examples of the various time frames in music and what bearings do they have individually and in combinations on the speed of the music?
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persistence of space: formalizing the polysemy of spatial relations in functional elements
On the 20th of June, Camil Staps successfully defended a doctoral thesis. Leiden University Centre for Linguistics congratulates Camil on this achievement!
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Research lines
Physics and Engineering Approaches to Biomedicine and Pharmacology
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Physics and Engineering Approaches to Biomedicine and Pharmacology
Mashaghi lab conducts research at the interface of physics, engineering and biomedicine. We develop and use theoretical and experimental approaches to address basic and applied research problems.
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Distinguishing differences in dementia using brain scans
Neuroscientist Anne Hafkemeijer is able to distinguish two different forms of dementia using advanced imaging techniques. This is the first step towards early recognition of dementia in patients on the basis of brain networks. PhD defence 26 May.
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Brain changes underlying social anxiety: numbers count!
In a recent mega-analysis, researchers from Leiden University aimed to clarify the contradictory findings of research into social anxiety disorder. They found that to obtain reliable research results having the largest possible sample size is important. Publication in NeuroImage:Clinical.
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Media attention for the learning adolescent brain
The brains of adolescents react more strongly to receiving rewards. This can lead to risky behaviour, but research in Leiden has shown that it also has a positive purpose: it makes learning easier. The publication of an article on the research findings led to a lot of media attention.
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Cognitive control in context: Neural, functional, and social mechanisms of metacontrol.
To argue that people can control the relative contributions of goal-driven and stimulus-driven processes to decision-making and action selection.
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STRUCTURAL AND EXPRESSIVE FUNCTIONS OF FLEXIBLE TREATMENT OF MUSICAL TIME, IN THE PERFORMANCE OF 19TH CENTURY MUSIC
This research will focus on the relationship between the musical structure and musical time in the performance of 19th century music.
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Het puberende brein
Eveline Crone wrote a new edition of
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Systematic investigations into the role of ceramide subclass composition on lipid organization and skin barrier
The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.
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stratum corneum lipid chain length relates to an impaired skin barrier function in patients with atopic dermatitis
Source: British Journal of Dermatology, Volume 170, Number 6, pp. E18-E19 (2014) ISBN:0007-0963
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New paper in Experimental Brain Research
Miranda Smit, Ineke van der Ham and colleagues have published a paper in Experimental Brain Research, entitled: Body ownership and the absence of touch: Approaching the rubber hand in- and outside peri-hand space.
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Anxiety traits are visible in the brain
Questionnaires or concentration tasks can be used to screen for anxiety, but so too can EEG recordings – at least indirectly. The frequent mind wandering of anxious people can also be seen on MRI scans. These are just some of the findings of clinical neuropsychologist Dana van Son. PhD defence on 24…
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Increased striatal activity in adolescence benefits learning
Heightened activation of the striatum that adolescents show in response to reward is often associated with risk-taking and negative health consequences. This article in Nature Communications investigates a potential positive side of this heightened activation. It shows that the activity peak in late…
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Inventing anchors? The function of ‘Greek models’ within the process of innovation in Early Roman Drama
To what end and how does Plautus constantly underline the Helleni(sti)c provenance of his art? How does this aspect relate the author’s originality?
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Electrical and magnetic properties of ferritin: electron transport phenomena and electron paramagnetic resonance
Ferritin is a spherical metalloprotein, capable of storing and releasing iron in a controllable way. It is composed of a protein shell of about 12 nm and within its cavity, iron is stored in a mineral form.
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Function and structure of the eye muscles in myasthenia gravis
PhD defence
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Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and
Source: Mol Psychiatry (2015)
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Like me or else...
Nature, nurture and neural mechanisms of social emotion regulation in childhood
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Determinants of and Interventions in Chronic Fatigue.
What are the most important perpetuating factors of chronic fatigue and chronic fatigue syndrome, and which interventions are effective in influencing these factors?
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Clinical Neuropsychology (MSc)
In the specialisation Clinical Neuropsychology, part of the Master in Psychology, you will focus on fostering clinical and scientific skills based on a solid theoretical background as well as practical training in neuropsychology and (clinical) neuropsychological research.
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What happens to the brain when you become a mother?
May 12 is Mother's Day in many countries. Becoming a mother is no mean feat: brain scientist Elseline Hoekzema has shown that a woman's brain changes drastically during pregnancy. She explained how in TV show De Kennis van Nu.
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SysMedPD: Systems Medicine of Mitochondrial Parkinson's Disease
The overall objective of this project is to identify novel drug candidates that are capable of slowing down the progression of neurodegeneration in the subset of Parkinson’s disease (PD) patients with overt mitochondrial dysfunction. Multimodal phenotypic characterisation of cohorts of monogenic PD…
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Navigating Between Principle and Pragmatism: The Roles and Functions of Atrocity-Related United Nations Commissions of Inquiry in the International
On 7 November 2018, Catherine Harwood defended her thesis 'Navigating Between Principle and Pragmatism: The Roles and Functions of Atrocity-Related United Nations Commissions of Inquiry in the International Legal Order'. The doctoral research was supervised by Prof. dr. L.J. Van den Herik and Prof.…
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‘Brain scanners are bringing about a revolution in neurolinguistics’
Brain scanners have radically changed neurolinguistics. They are increasing our understanding of how the brain processes language. Professor Niels Schiller has produced a standard work on this.
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Deciphering the link between Iron and Brain Disease
Aceruloplasminemia is a very rare, genetic disease accompagnied with iron accumulation that causes movement disorder and brain damage at early age.
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Leiden delves into the mystery of the brain and language
The Leiden Institute for Brain and Cognition (LIBC) is concentrating increasingly on research into the role of the brain in language development. The institute has now set up the LIBC Language website that brings together all the information on this research.
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The LeiCNS-PK3.0 model development and applications: healthy-to-diseased CNS pharmacokinetic translation
Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…
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Volunteers needed for brain study in resilience research project
Why do some people with adverse childhood experiences develop mental health conditions whereas others do not? A Leiden research project is looking for volunteers aged between 18 and 24 to help us understand more about human resilience.
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Lara Wierenga
Faculteit der Sociale Wetenschappen
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Marcella Pavias
Faculteit der Sociale Wetenschappen
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Jiska Peper
Faculteit der Sociale Wetenschappen
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Pilgrims came to Leiden for ‘brain training’
The Pilgrims to America exhibition at Museum De Lakenhal inspires reflection. How far do you go in the quest for freedom? It focuses on the Pilgrims’ relationship with the University and which knowledge they took with them from Leiden.
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polypept(o)ides: from secondary structure formation of polypeptides to functional cross-linking strategies for polymeric micelles
This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.
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Nutrition and fasting for the brain: why the Keto diet shows promise
Autism, Alzheimer’s, and bipolar disorder: can the development of these mental health conditions be influenced by the ketogenic diet? Increasingly, research suggests it might. 'For those it helps, it can be life-changing,' says neuroscientist Eline Dekeyster.
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How does the brain of Japanese speakers choose pronunciation?
The way in which written language is processed in the brain is a hot topic in cognitive research. Cognitive psychologist Rinus Verdonschot studied a Japanese script in which a single character can have up to three possible pronunciations. He discovered that all three are simultaneously activated in…
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Azafaros is valorizing a library of compounds
The company Azafaros was established in 2018 to translate innovative science from Leiden University and Amsterdam University Medical Center into novel disease-modifying treatment modalities for rare genetic metabolic disorders such as lysosomal storage diseases.