The lipid matrix in the stratum corneum (SC), the upper layer of the skin, plays a critical role in the skin barrier. The matrix consists of ceramides (CERs), cholesterol (CHOL) and free fatty acids (FFAs).

The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.

In this article, Friso Selten and Bram Klievink explore how public organisations strategically manage the adoption of AI.

Heterogeneous catalyzed processes are highly significant to the chemical industry. Dissociative chemisorption (DC) of molecules on surfaces is always considered as a step with a high degree of rate control for heterogeneous catalysis.

In his PhD research in the field of public administration, Mark Reijnders looked at why people do not receive the help they need. They lose their way in the labyrinthine support system or become bogged down in bureaucracy. In public administration this is known as non-take-up of social care. PhD defence…

Lecture

Chromatin is an ubiquitous protein-DNA complex that forms the structural basis of DNA condensation in all eukaryotic organisms.

Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…

Maral Jefroudi defended her thesis on 11 October 2017

Serhan Afacan defended his thesis on 23 June 2015

On behalf of the interdisciplinary programme Social Resilience & Security, we would like to remind you of the call for proposals for seed funding (up to €4.000) to boost interdisciplinary research.

This 48-month project is to contribute to a solid, accessible, domestically owned knowledge base for people-centred interventions aimed at strengthening access to justice in Libya (A2JiL), and to disseminate such knowledge among stakeholders, enhancing awareness and the capabilities required to provide…

The research project addresses the question how complaints in the voluntary youth care system are dealt with on the municipal level and what role (municipal) Children’s Ombudspersons play in this context, through qualitative research methods.

Chaider Bamualim defended his thesis on 9 September 2015

On 15 February 2022, Morshed Mannan defended the thesis 'The Emergence of Democratic Firms in the Platform Economy: Drivers, Obstacles, and the Path Ahead'. The doctoral research was supervised by Prof. I.S. Wuisman and Prof. J.A.A. Adriaanse.

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

The League of European Research Universities (LERU) makes recommendations for the future of the Social Sciences and Humanities research in Europe. Social Sciences and Humanities (SSH) research is vital to build an innovative and resilient Europe.

PhD defence

PhD defence

Delineating psychophysiological endophenotypes of social anxiety disorder

Understanding the evolving landscape of extremism in the 21st century.

The advanced insights obtained for the CNS PBPK model development are currently used to develop advanced mathematical models for drug distribution prediction in other body tissues protected by barriers, such as the gut. The gut PBPK model will be linked to drug effects for treatment of colon cancer.

From 23-25 April 2014, a conference will be held on the topic of Buddhism and Social Justice. This conference confronts the common perception of Buddhism as intrinsically a tradition of peace and justice, and explores the various ways in which historically Buddhist societies of Asia have shaped, transmitted,…

PhD defence

Do large deletions represent a risk during CRISP/CAS9-mediated genome editing in plants?

Peak Performance: Collaborative Crisis Management Before and During International Summits. This comparative case study probes into conditions for collaborative governance in the security organisation of international summits.

Promotor: Prof.dr.ir. T.H. Oosterkamp, N. de Jonge

Promotor: Prof.dr. J. Kuiper, Co-Promotor: S.C.A. de Jager

Sewer pipes are an essential infrastructure in modern society and their proper operation is important for public health. To keep sewer pipes operational as much as possible, periodical inspections for defects are performed.

In an appeal case, an employee of a care organisation in Nijmegen who was shown the door because of her criticism about the coronavirus voiced on LinkedIn, has had her dismissal reviewed. The court in Arnhem ruled that the employee had crossed a line and that her employer was entitled to dismiss her…

It was already known that social anxiety disorder often affects more than one person in the same family. But research by PhD student Janna Marie Bas-Hoogendam has now shown that there are genetic brain characteristics that are associated with social anxiety. The PhD ceremony will take place on 14 Ja…

Negative perceptions of ambiguous social cues, social performance and physical arousal in socially anxious youth

Geology and Paleobotany of the Area surrounding the Archaeological Excavation at the Hazendonk River Dune (Western Netherlands).

Stratigraphy, Palaeoenvironment and Archaeology of the Middle and Late Pleistocene Deposits.

Another research line is the development of a spatial CNS drug distribution model, by ultimately including the 3-dimensional anatomical organization of the CNS.

The aim of this study is to further develop the Open Science Monitor, which started as a pilot study.