The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.

In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.

Accelerating the diagnosis and personalising the management of inherited metabolic diseases.

Science, Leiden Institute of Chemistry (LIC)

The newly opened Culture Arcade exhibition is a place where cultural heritage and video games come together. It is co-organized and curated by the VALUE Foundation of which Faculty staff members Aris Politopoulos and Csilla Ariese-Vandemeulebroucke are part of, together with the Prince Claus Fund.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

Physicist Martin van Exter works with light at nanoscale, at the forefront of nanocomputer research. But as Director of Education he also has a vision for physics teaching. Inaugural lecture 18 November.

We review the state-of-the-art in the theory of dissociative chemisorption (DC) of small gas phase molecules on metal surfaces, which is important to modeling heterogeneous catalysis for practical reasons, and for achieving an understanding of the wealth of experimental information that exists for this…

Most of current public-key cryptography is considered insecure against attacks from sufficiently powerful quantum computers. Post-quantum cryptography studies methods to secure information resistant against such attacks. One proposal is isogeny-based cryptography, which bases its security on computational…

Nonparametric Bayes for high-dimensional models: contraction, credible sets, computations

Sander Hölsgens is Assistant Professor, anthropologist and the editor of Gamer.nl. In NRC he talks about his favourite moments in the online game The Elder Scrolls Online. Despite a mediocre start in 2014, the computer game based on the Elder Scrolls series now has an active community of millions of…

Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…

Natural Computing is the field of research that investigates both human-designed computing inspired by nature and computing taking place in nature, i.e., it investigates models and computational techniques inspired by nature and also it investigates phenomena taking place in nature in terms of information…

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.

This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…

Source: Nat Biotechnol, Volume 32, Issue 12, pp. 1213-22 (2014)

HEPGAME is a research project that combines the world’s fastest computer algebra system for High Energy Physics equations, FORM, with insights from artificial intelligence. The name combines High Energy Physics and Games.

Can we use quantum computers in a way that is also relevant to society? With the help of a 2-million-euro NWA grant, Leiden University will work with partners such as Surf, Google and Volkswagen to demonstrate that quantum computers are also of value outside the lab.

On Thursday 18 December, 170 first-year pupils from Gymnasium Haganum visited Leiden University’s Faculty of Governance and Global Affairs (FGGA) in The Hague. The faculty has developed The Great Migration Game (Het grote Migratiespel) as a fun way to introduce pre-university pupils to its fields of…

Infecting each other with viruses and bacteria while protecting yourself with medicines and vaccinations. Sounds like a fun evening, right? Master students Life Science & Technology Rafael Jezior and Dennis de Beeld certainly think so. Together, they developed ImmunoWars: an exciting card game based…

Academia and games. One is for serious people who only have time for research, the other is a pastime best avoided if you are or want to be one of these serious people, right? Not at all!

The 18.8 million euro NWO Zwaartekracht grant for quantum software which Amsterdam, Delft and Leiden landed collectively, means for Leiden University among others the appointment of two new permanent scientific staff members, who will each form their own research group, divided among Computer Science,…

Exhibition

Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.

PhD defence

How do humans control their thoughts and actions, and what can high-field brain scanning reveal about the underlying processes?

In her daily life, she is a student of Life Science and Technology, but not this summer. Guusje van Bolhuis is participating in the Olympic Games with the French hockey team. ‘Studying and playing hockey at top-level are very different, but with the right mindset, you can go far in both.’

This dissertation shows that dialogical logic constitutes a powerful and flexible general framework for the development and study of various logical formalisms and combinations thereof.

The quantum computer is on its way, but is society ready for it? Quantum computers have a reputation of being difficult to grasp because of their complexity. This limits society’s ability to envision future applications creating a gap between society and quantum computers. A consortium of 14 knowledge…

In a global effort, quantum computers are rapidly being developed. In the meantime, researchers have to learn how to write code for these devices, which are fundamentally different from conventional computers. A collaboration of scientists led by Google, and including physicists from Leiden and Delft,…

In the new board game Epoch – Early Inventors you explore the prehistoric landscape. You gather food and raw material to develop tools and skills, and you try to appease the gods. Dr Maikel Kuijpers was involved in its development from the start and he is very happy with the result. “There is a lot…

Studying and being an entrepreneur at the same time? Stan (21), a master's student in Crisis and Security Management, is doing it. With the knowledge gained from his master's, he developed a game about cybersecurity: HackX. Through HackX, he wants to make others aware of dangers online.

If computers work on superconducting current, they won’t consume any energy. Leiden physicists have now gained control over a new type of superconducting memory elements. Publication in Nature Communications.

Not many scientists can claim to have received funding from NWO to blow bubbles and play with sand, but Martin van Hecke definitely can. Van Hecke, Professor of the Organisation of Disordered Matter, delivered his inaugural lecture on Friday 4 September, under the enigmatic title of: ‘Bellen, bollen,…

In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.