How do nonmotile microbes leverage communal motility?

The majority (80%) of e-waste generated globally are recycled informally in developing countries.

Is translocation of nucleases possible via Agrobacterium T4SS and is it efficient enough for mutagenesis?

PhD defence

PhD defence

PhD defence

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

Some people are predisposed to develop cancer. Mutations in genetic material that increase a person’s chances of developing cancer can already be present at birth. Researchers are closely examining these mutations to learn more about how cancer begins to develop.

Pathogenic bacteria are increasingly resistant to today’s antibiotics. Professor Gilles van Wezel seeks new forms of antibiotics in good bacteria that live in the soil.

This project investigates the well-preserved agricultural terraces of the Inn valley and the evolution of resource use in the inner Alps.

The filamentous bacteria Streptomyces are widespread inhabitants of terrestrial soils.

Promotores: Prof.dr.G.R. de Snoo and Dr. R. Heijungs

Around the world, there is a growing movement to decolonise university curricula, with both students and educators seeking to disrupt existing epistemic hierarchies within higher education. This research project aims to unravel what decolonising means in general and what it means for the International…

Four promising young researchers will be able to conduct two years of research at a university abroad thanks to a Rubicon grant from the Dutch Research Council (NWO). The Leiden laureates are Renske Janssen, Girija Josh, Anne van der Meij and Yana van der Weegen.

Bacteria and fungi on organic dairy farms are significantly different from those on conventional farms. That was discovered by postdoc researcher Sofia Gomes and her supervisors Nadia Soudzilovskaia and Peter van Bodegom in collaboration with the Louis Bolk Institute and Naturalis Biodiversity Centre.…

The Skin Barrier and Vaccination group is led by Prof. Joke Bouwstra. One of the key functions of the skin is its barrier function, which is located in the uppermost layer of the skin, the stratum corneum. The stratum corneum consists of enucleated dead cells (corneocytes) embedded in a lipid matrix.…

A team of researchers has managed to recreate the most natural skin cream in existence. Using the DUBBLE beamline (Dutch Belgian Beamline) at the European Synchrotron Radiation produced on the basis of the information identified, has the same properties as vernix caseosa. This cream may have a therapeutic…

Chromatin is an ubiquitous protein-DNA complex that forms the structural basis of DNA condensation in all eukaryotic organisms.

Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…

Can we use indigenous microbial rice communities to reduce methane production in agricultural settings?

The research within the Food research programme at CML focuses on a transition towards sustainable food production and consumption systems. We investigate from a very small to a very large scale, at a local, national or international level. We do so by researching for example molecular tools, food systems,…

In 2016, CML published over 90 papers, successfully crowdfunded the Living Lab project, celebrated a royal honour for associate professor Hans de Iongh and contributed to the Global Soil Biodiversity Atlas. CML awarded five PhDs and taught students from all over the world how to contribute to sustainability.…

Ecotox is a stimulating top-facility that provides an integrative research environment around the topic of ecotoxicological testing and experimental research. Research focus: Dose-response modelling Mode-of-actions and mechanism-of-actions Test method development, in view of targets in AOPs (adverse…

PhD defence

Regenerative medicine is a new way of treatment that helps impaired cells, tissues, and organs work well again. We do this by repairing, replacing, or restoring cells, tissues, and organs after damage from illness or injury. This includes treating long-term diseases such as diabetes, kidney diseases,…

Osteoarchaeologists help forensic scientists solve crimes. They also study bone material from the Second World War in order to identify victims.

Increasing above- and belowground biodiversity in arable leek cultivation to stimulate pest control by natural enemies.

Biodiversity is under pressure worldwide, but is essential for our health, food security and well-being. What is the influence of human actions on ecosystems? Can we provide biodiversity-inclusive solutions for our key societal challenges? These questions are central to the Biodiversity research the…

A liveable planet. More biodiversity. And resources which are being managed wisely. At the CML, we want to make an impact with our research and education. On this website you can read what we do to achieve that.

Do large deletions represent a risk during CRISP/CAS9-mediated genome editing in plants?

Focus in skin research

Promotor: Prof.dr. J. Kuiper, Co-Promotor: S.C.A. de Jager

Peak Performance: Collaborative Crisis Management Before and During International Summits. This comparative case study probes into conditions for collaborative governance in the security organisation of international summits.

Sewer pipes are an essential infrastructure in modern society and their proper operation is important for public health. To keep sewer pipes operational as much as possible, periodical inspections for defects are performed.

Promotor: Prof.dr.ir. T.H. Oosterkamp, N. de Jonge

Key publications of the Skin Barrier and Vaccination group.

Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri

Since the adoption of agriculture people have cultivated fields. The project concerns all kinds of aspects related to raising crops.

Did early farmers deliberately use animal manure on their fields?

Promotor: Prof.dr. G.P. van Wezel

How do you fit two meters of DNA in a tiny compartment and at the same time are able to access the right parts of it at the right times?

An important feature of atopic eczema (AE) is a decreased skin barrier function. The stratum corneum (SC) lipids - comprised of ceramides (CERs), free fatty acids (FFAs) and cholesterol - fulfill a predominant role in the skin barrier function.

Multi-objective optimization is an effective technique for finding optimal solutions that balance several conflicting objectives. It has been applied in many fields of our world, because practical problems usually have more than one desired goal. For example, developing a new vehicle component might…

The wealth of shoes, sandals and other footwear from ancient Egypt is poorly understood due to lack of research. This is remarkable, because from the very beginning of Egypt’s long history footwear served practical as well as more spiritual purposes.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

In the fall of 2021, Cleveringa professor Roméo Dallaire and world experts shared their thoughts about PTSD, children’s rights, war crimes, humanitarian law, and peacekeeping in a series of conversations about leadership and moral dilemma during times of conflict and crisis.

Following the Beirut explosion, BBC's podcast series The Foodchain explores the chemical that caused the blast: ammonium nitrate. A compound that is widely used to produce fertilizer. Professor of Environmental sustaibability Jan Willem Erisman tells about the effects of nitrogen on the environment.

What are the key issues in conducting LCA of bioenergy systems? What is the environmental sustainability status of second generation bioethanol? How much would the final results of biogenic carbon neutrality assumptions deviate from the true values based on a complete inventory? How to assess the impact…

How can we quantify the density of species within a community through environmental DNA concentrations?