2,918 search results for “disease prevention” in the Public website
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INFLANET - Training European Experts in Inflammation: from the molecular players to animal models and the bedside
How is inflammation in tuberculosis controlled by interplay between autophagy and inflammasome signalling?
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Spreading the Fire: Why is Pyroptotic Cell Death Contagious?
The word ¨pyroptosis¨ can be understood as ¨fiery falling¨, which describes the bursting of pro-inflammatory signals from the dying cell. Our observations indicate that pyroptosis also ¨spreads like wildfire¨ and once a cell dies via pyroptotic cell death, neighbouring cells are more prone to die as…
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International Society for the Prevention of Child Abuse and Neglect in The Hague
On 2 and 3 October 2017, a delegation of the Child Law Department has participated in the 15th European regional conference of the International Society for the Prevention of Child Abuse and Neglect in The Hague.
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UV radiation from massive stars prevents formation of Jupiter-like planet
An international team of scientists, including Xander Tielens of Leiden Observatory, has used space telescope Hubble and the ALMA observatory to show that UV radiation from massive stars can prevent planets from forming. The researchers publish their findings on 1 March in the journal Science.
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The power of positive peers for socially anxious youth
Can positive peer feedback break the cycle of negative self-relevant cognitive processes and reduce self-reported anxiety in early adolescents?
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Cryo-EM of cholera infection
The structure of bacterial cells provides crucial clues about their interaction with their host. What are the key structural features of a bacterial cell that determine pathogenicity? What roles do these structures play in the life cycle, and how do they change during the infection process?
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Leiden University and LUMC strengthen ties with Janssen pharmaceutical company
Leiden University, the LUMC and Janssen have signed a partnership agreement stating that they will collaborate in different areas, including infectious disease prevention, clinical tests, drug production and e-health. By joining forces, the three partners will be able to provide better, more innovative…
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Inflammafish: Cross-talk between inflammation and autophagy in tuberculosis
Effective host defence against tuberculosis bacteria depends on a properly balanced level of inflammation. The Inflammafish project uses zebrafish larvae to study how autophagy controls this inflammation and vice versa.
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Roeland Merks
Science
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Patrick van Hage
Science
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Maria Yazdanbakhsh
Faculteit Geneeskunde
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Jordy van der Beek
Science
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Joey Zuijdervelt
Science
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Tuomas Aivelo
Science
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Coen van Hasselt
Science
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Metabolomics Facility officially in operation
The Metabolomics Facility of Leiden University is now officially in operation to prevent disease and to improve health throughout the human lifespan.
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Interview with Edwin Bakker about the Summer Programme Preventing Violent Extremism
Edwin Bakker is one of the speakers during the
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Microengineered Human Blood Vessels For Next Generation Drug Discovery
Heart failure is a major health care problem with high mortality.
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Innovative strategies to clinically characterize the human tear proteome
Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.
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Exposed to events that never happen: Genaralized unsafety and prolonged psysiological stress responses
The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.
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Amanda Foks receives Dekker grant from Dutch Hartstichting
Pharmacologist Amanda Foks is one of the ten talented scientists who received a Dekker grant from the Hartstichting. She receives €427,000 to find a way to rejuvenate immune cells to prevent infarcts. Foks was nominated as Discoverer of the Year in 2016.
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Nitric oxide in defence against mycobacterial infection
Can we enhance the capacity of host immune cells to kill mycobacteria via production of reactive nitrogen species?
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Clock disruption in diurnal versus nocturnal migrating fish
Does Artifical Light at Night (ALAN) disrupt seasonal physiological and behavioral patterns in migrating freshwater fish?
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the Social Resilience & Security programme: investigating suicide prevention skills and mental health of Ukraine refugees
The Social Resilience & Security interdisciplinary programme broadens its scope by embedding two research projects lead by Dr. Joanne Mouthaan. The projects adress suicide prevention skills and mental health of Ukraine refugees. Both projects will be integrated in the programme with the aim to improve…
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SKY HIGH: Vertical farming a revolution in plant production
As a new vision on food production, the feasibility study on LED light to grow crops with the biological- and chemical evaluation of final products.
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Horizontal gene transfer and spreading of biosynthetic gene clusters and antimicrobial resistance
Biosynthetic gene clusters (BGCs) for natural products are widespread in microbial genomes, and they are rapidly exchanged. This research assesses the factors that control the spread of BGCs and resistance genes in nature. This includes risk assessment for the spread of engineered DNA in nature.
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Marker assisted breeding for thrips resistance in tomato
Which plant leaf characteristics are involved in thrips resistance in tomato?
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Layers of dental tartar
Bacteria in the teeth tell us a lot about nutrition and disease in our ancestors. It also tells us more about the immune system. This provides clues for treating modern diseases and allergies. For a long time archaeologists were irritated by tartar on the teeth of excavated skulls. They thought that…
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Mycobacterial cell wall-deficiency and its role in the persistence of tuberculosis
What is the role of cell wall-deficiency in the persistence of tuberculosis?
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How could government prevent the next benefits scandal? ‘Be vulnerable and share your data’
Professor Anne Meuwese is calling on governments to show more vulnerability when it comes to providing information about how they function.
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Leiden University Medical Center
In the Leiden University Medical Centre (LUMC) we strive to improve health care and the health of people.
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Alastair Reed about preventing violent extremism in post-siege recovery
Alastair Reed, Assistant professor at the Institute of Security and Global Affairs (ISGA) is interviewed by Devex, the media platform for the global development community.
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Topic: Stress and stress-related disorders
The precise psychobiological mechanisms leading to chronic physiological stress responses have not been sufficiently explained, although stress is a major risk factor for disease and early death. A problem for conventional stress theory is that most of these responses seem to occur in situations without…
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Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and
Source: Mol Psychiatry (2015)
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Finding the cause of memory loss
Memory loss and confusion are signs of Alzheimer’s disease. Physicists Serge Rombouts and Martina Huber have developed new methods to help medical science get to the bottom of this insidious disease.
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Liesbeth van der Heide on Dutch NPO Radio 1 on recognising and preventing radicalisation
There is a lot of unrest in the Western Sahel at the moment as a result of growing Jihadism and terrorist attacks. Stability and security in the region are falling apart making room for growing radicalisation. But what do you need to look out for in order to be able to recognise radicalisation and what…
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ImageInLife: Training European experts in multilevel bioimaging, analysis and modelling of vertebrate development
How can novel bioimaging technologies and vertebrate model species be used to gain a better understanding of early cellular behaviours with the ultimate goal to increase our understanding of human development and disease processes?
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Finding a cure for rheumatoid arthritis
Professor Tom Huizinga (LUMC) specialises in rheumatoid arthritis. He joined forces with alumni and the Natuurwetenschappelijk Gezelschap Leiden, a society that aims to share knowledge of the natural sciences and medicine, to explore the symptoms of the disease. With this form of arthritis the fluid…
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Frits Rosendaal
Faculteit Geneeskunde
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Annemarie Meijer
Science
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Zebrafish: a new engraft model to study Ewing sarcoma progression
Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?
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Teeth Tell Tales
A multi-disciplinary approach to past lifestyles and cultural practices
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Distance-based analysis of dynamical systems and time series by optimal transport
Promotor: S.M. Verduyn Lunel
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Topic: Movement and mental functions
Our ability to learn and control movements is essential for engaging in goal-directed behaviour. From buttoning your shirt and driving a car, to cooking dinner and brushing your teeth -- our actions in daily life rely on this ability.
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Chemokine signaling in Tuberculosis and Salmonella infection
Who benefits from CXCR/CXCL chemokine signaling during infection: host or pathogen?
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Report presented at expert workshop on EU's proposed regulation on preventing and combatting child sexual abuse
Workshop brings multidisciplinary experts together to produce interdisciplinary outcomes on the EU’s Proposal for a Regulation to prevent and combat child sexual abuse.
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Vincent Delhomme and Carina Van Os on 'The European Health Union'
On 1 and 2 December 2022, Vincent Delhomme and Carina van Os participated (Europe Institute) in the workshop ‘The European Health Union - Setup, challenges and global outlook’, held at the Max Planck Institute for Comparative Public Law and International Law in Heidelberg. Vincent had the opportunity…
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Photocleavable activity-based acid glucosylceramidase probes
Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…
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Small changes for long term impact: optimization of structure kinetic properties: a case of CCR2 antagonists
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman
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Live or let die: the intracellular fate of pathogenic mycobacteria
How do mycobacteria subvert the defenses of host immune cells?