How distance-dependent is graphene as biological sensor?

A major challenge in the formulation of biopharmaceuticals is to overcome their inherent instability during production, storage, transportation, handling and administration. We are studying underlying mechanisms of degradation of biopharmaceuticals (including therapeutic proteins, vaccines and advanced…

Research groups in the Biological & Soft Matter Programme unravel mechanisms in biological processes and develop novel bio-inspired soft materials.

The research groups within the biological, soft and complex systems research area study the physics of a broad range of biological and soft materials. This spans both experimental and theoretical research.

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

We study the physics of a broad range of biological and soft materials

Schneider

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

The Physics and Biological and Soft Matter master's specialisation is one of the two programmes that Leiden University offers in experimental physics. This programme mainly focuses on Biological Physics and Soft Matters Physics.

Learning about circadian rhythms can help students to improve their sleep and overall well-being

Oxidation is a common degradation pathway that affects therapeutic proteins and peptides during production, purification, formulation, transportation, storage and handling of solid and liquid preparations. In the present work we review the scientific literature about structural and biological consequences…

How do nanoparticles bioaccumulate and biodistribute in organisms?

Are there acoustic cues for settlement stage larvae in deep-sea soundscapes around hydrothermal vents?

1. To what extent do metallic NPs added to soil extractions change the activity, abundance, or community composition of microbes? 2. How do the effects of metallic NPs on soil microbes differ from the effects of the ions shedding from corresponding NPs?

Research in the Daniela Kraft Lab focuses on self-assembly in biological and soft matter systems, ranging from anisotropic colloidal particles to lipid membranes, emulsions, and viruses.

Can we develop a generic method for Quan/Qual analysis of small molecule drugs, their metabolites and endogenous metabolites in (pre-)clinical samples?

Promotores: H. Schiessel, G.T. Barkema

It has been a long-standing mystery how complex biological structures emerge from such seemingly uncoordinated building blocks as cells and tissues, in the presence of only minimal environmental guidance.

What is vegetation structure and composition in SFM primary forest, secondary logged over forest (logging FSC certified and logging non certified) in comparison to primary forest? What is avian guild diversity in SFM primary forest, secondary logged over forest (logging FSC certified and logging non…

Source: Bioorg Med Chem, Volume 23, Issue 14, pp. 4034-49 (2015)

Description of The Regional Network on the Synergy between the Convention on Biological Diversity and the UN Convention to Combat Desertification.

This year's Nobel Prize for Medicine goes to the three American researchers who have unravelled the mechanism behind the biological clock. Joke Meijer, Professor of Neurophysiology and an expert in the field of the sleep-wake rhythm, explained in Dutch newspapers Trouw and NRC why this discovery is…

Researchers at LUMC are trying to decipher the biological clock. This knowledge can help deal with luxury problems, such as jetlag, but can also counter diseases. Molecular neurobiologist Erno Vreugdenhil explains.

The aim of this project is to explore the use of statistical interaction models to quantify cross-omics and omics-drug interactions in large-scale clinical and experimental datasets

On Friday the 6th of December, the annual symposium of the IBL was organized at the Buruma theatre (LUMC), Leiden. This year’s theme was “Biological Networks from Molecules to Society”.

During Seeing Stars Leiden all the lights around Leiden Observatory will be switched off for an hour. The more lights that go out, the more stars we’ll be able to see. For the LUMC, this is the perfect moment to think about our biological clock, the topic researchers from the BioClock consortium are…

Using biologically inspired algorithms on 'edge devices', such as cameras and mobile phones, is what Svetlana Minakova's PhD research was all about. She conducted research on Convolutional Neural Networks(CNN). Making these algorithms work in different situations is a complicated task. 'Most design…

This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.

Dutch researchers are joining forces to conduct research together with a series of societal partners to keep the biological clock healthy in our modern 24-hour society. The BioClock consortium will receive a research grant of no less than 9.7 million euros for this. It is one of the projects that receive…

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

The Quantitative Pharmacology group headed by Coen van Hasselt focusses on the application of state-of-the-art quantitative pharmacometrics and systems pharmacology modeling combined with translational experimental models to develop personalized treatment strategies for antibiotics and to combat antimicrobial…

Ontwikkeling van resistentie tegen antibiotica kan optreden als patiënten onnodig of te lang met antibiotica behandeld worden. Diagnostiek waarmee snel een bacteriële infectie vastgesteld kan worden, of de response op antibiotica bepaald kan worden, zijn daarom belangrijk om therapie te optimaliseren…

The Dutch colonial past in Indonesia has had a major influence on literature.

Optimization, mechanisms of action and predictors of the outcome of light therapy in depression: A multicenter randomized trial

Promotor: Prof.dr. P.G.L Klinkhamer