1,230 search results for “anti-cancer drug steen” in the Public website
-
Partner Institutes
The IBL represents the core of modern biological research at Leiden and we interact closely with the other life science Partner Institutes in the faculty:
-
Staphylomics: Identifying host factors involved in staphylococcal infection
How can Staphylococcus aureus bacteria subvert the host immune system?
-
To explore the drug space smarter: Artificial intelligence in drug design for G protein-coupled receptors
PhD defence
-
Tailor-made medicines
More and more medicines are becoming available that target a tumour’s specific traits. The use of chemotherapy is continually undergoing improvement.
-
AiChemist project
The AiChemist project (https://aichemist.eu) coordinated by Helmholtz Munich is an Innovative Doctoral Training Network funded through the Marie Skłodowska-Curie Actions (MSCA-DN) within the EU Horizon Research Framework, to the sum of €3 million. It brings together leading experts in AI, chemoinformatics…
-
Binding kinetics
A tantalizing concept that has emerged in our recent research is binding kinetics. An important parameter is residence time (RT), a direct reflection of how long a drug stays bound to its target. This parameter is of crucial importance, because drug action lasts only as long as the receptor-ligand complex…
-
BioTherapeutics
Research in the BioTherapeutics research programme is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.
-
Regulation of nanoparticle biodistribution by scavenger endothelial cells (SECs)
A very large part of intravenously administered nanoparticles are cleared through the liver. Within the liver, most nanoparticles are thought to be sequestered by macrophages (Kupffer cells). To achieve effective cell-specific targeting of drugs and non-viral gene delivery vectors, improved mechanistic…
-
Environmental and metabolomic study of antibiotic production by actinomycetes
Promotor: Prof.dr. G.P. van Wezel
-
Core cross-linked polymeric micelles based on polypept(o)ides: from secondary structure formation of polypeptides to functional cross-linking
This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.
-
Societal impact
Research from the Living Lab is important for society. For example, scientists from the Living Lab discovered that the pesticide thiacloprid is up to 2,500 times more harmful to insects than was thought on the basis of regular lab research. Partly because of this discovery, the European Commission decided…
-
Knowledge discovery from patient forums: gaining novel medical insights from patient experiences
Patients share valuable advice and experiences with their peers in online patient discussion groups.
-
Development of novel metabolomics & systems pharmacology concepts to realize personalized medicine
The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments.
-
Cheminformatics: Analyzing small-molecule activity data
While bioinformatics methods deal with the analysis of sequence information (be it proteins or DNA), the field of cheminformatics is concerned with the analysis of small-molecule datasets.
-
Grants & Awards
Grants awarded to molecular physiology research
-
Finding and valorizing new antibiotics using AI
Antibiotics are a class of medicine most people take for granted. But pathogenic bacteria are becoming more and more resistant to our antibiotics, and this poses a great challenge for future treatments. There is thus a great societal need to identify new molecules that can address new targets and be…
-
Pharmacological resting-state fMRI in aging and dementia
How can we implement the technique of pharmacological resting-state fMRI to improve the diagnosis of dementia?
-
Boosting the host immune system to fight tuberculosis
New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.
-
LED3 Lectures
The LED3 hub, consisting of researchers from the Leiden Institute of Chemistry (LIC), the Institute of Biology Leiden (IBL) and the Leiden Academic Centre for Drug Research (LACDR), is very excited to organize the “LED3 Lectures”. This lecture series brings world-leading researchers in the field of…
-
Affinity
Designing and synthesizing high-affinity ligands for a given drug target have always been among the more important challenges in the drug discovery process.
-
Career prospects
Many students receive their first job offer during or right after their Business Studies internship. After graduating you can also aim for a career in Bio-Pharmaceutical research.
-
Overview
The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterise and predict variation in treatment response and enhance translational drug development strategies.
-
Animal-free chemical safety testing with new technology ToxProfiler
Toxys, Leiden University and Leiden University Medical Center have agreed immediately to commercialise and also develop further the ToxProfiler technology invented at the two institutions. ToxProfiler allows for rapid toxicity hazard identification of novel and existing drugs, chemicals, and other substances.…
-
Combatting infectious diseases; nanotechnology as a platform for rational vaccine design
Currently, several successful vaccines are available. However, for pathogens with a highly variable genetic composition, and for which serum IgG antibodies are not a useful correlate of protection, effective vaccines are yet to be developed.
-
Less is more: reduced mycelial heterogeneity for improved production of enzymes and antibiotics
How can cell wall engineering approaches be used to improve streptomycetes for industry to make new antibiotics?
-
Assistant professor "Inflammation pathways in atherosclerosis"
Science, Leiden Academic Centre for Drug Research (LACDR)
- GTGC lunch seminar: Santino Regilme on Global Drug Wars
-
Cancer pathogenesis and therapy
With cancer, a person’s body cells grow uncontrollably. Putting together a detailed picture of how this comes about makes it possible to develop efficient therapies. Researchers at the Leiden University Medical Centre (LUMC) and Leiden University are working together to gain a better understanding…
-
Researchers reveal how stem cells make decisions
Embryonic stem cells have the remarkable ability to develop into any type of cell. On their way to become for example a liver or a heart cell, they must repeatedly decide between alternative developmental paths. How they make these decisions is largely unknown. An international team of biophysicists…
- Contact
-
Staff
The Cyber Security lecturers are scholars and lecturers of Leiden University, Delft University of Technology and The Hague University of Applied Sciences.
-
Vascular and Regenerative Medicine
Methods of treatment for chronic illnesses are limited. Doctors and researchers at Leiden University Medical Center (LUMC) and Leiden University are working on new therapies as an alternative for organ transplants. The goal is to cure the illnesses by restoring organs to their original function. Stem…
-
About the programme
The two-years MSc programme spans the entire spectrum of Analytical BioSciences, Biopharmaceutics, Drug Delivery Technology, Medicinal Chemistry, Pharmacology and Toxicology.
-
Medicine development is hunting magic bullets
Medicines are becoming increasingly precise and innovative, but at the same time increasingly expensive. With their innovations, it is up to universities to increase competition, thus causing prices to drop. This is what newly appointed Professor of Biomolecular Analysis Hubertus Irth argues. His inaugural…
-
Key publications
Key publications of the Predictive Pharmacology group.
-
Stem cells suppress rejection in organ transplants
Treatment with special stem cells seems to be a good option for suppressing the immune system in organ transplants. Researchers are trying to learn from processes that take place in the human body during pregnancy.
-
Policing the high seas: maritime law-enforcement in a multi-actor environment
Identifying the gaps in the legal framework for EU activities in the maritime security domain, and specifically in the areas of combating piracy, human smuggling or trafficking and drug trafficking.
-
Maritime Security
The project 'Policing the high seas: maritime law-enforcement in a multi-actor environment' aims to identify the gaps in the legal framework for EU activities in the maritime security domain, and specifically in the areas of combating piracy, human smuggling or trafficking and drug trafficking.
-
Key publications
Key publications of the Quantitative Clinical Pharmacology group
-
Partnerships
The LACDR represents the core of bio-pharmaceutical research at Leiden University, and we interact closely with our partners:
-
Key publications
Key publications of the Quantitative Pharmacology group
-
Selectivity
Target selectivity is an important aspect of any drug molecule, and certainly a parameter to be optimized. That is not trivial for a number of reasons. First of all hundreds of drug targets (receptors, enzymes, ion channels) exist, and no single lab in the world has assays for all of them.
-
Control theory methods for quantitative systems pharmacology models
Following their application to system biological models, control theory techniques have further potential to aid in the understanding and application of quantitative systems pharmacology models.
-
Education
Pharmacy undergraduate education at Leiden Pharmacy combines the strong scientific foundation of the bachelor programme Bio-Pharmaceutical Sciences with experience-based learning and a strong focus on pharmaceutical patient care and pharmaceutical treatment in the master programme Pharmacy.
-
Receptor Residence Time
Research question
-
Streptomyces as cell factories
We aim to engineer streptomycetes to fully exploit their potential for natural product productions, by a rational design and evolution approach.
-
Career prospects
With an MSc degree in BPS and Science Communication & Society you are well prepared for a broad array of career prospects in research or industry. The master’s degree is an excellent preparation for a career at the interface of science and public affairs.
-
Why Leiden University?
We are committed to provide you with meaningful, rigorous and quality graduate experiences in a personalized environment with a cutting edge research infrastructure and internationally renowned supervisors.
- Contact
-
Systems pharmacology of the amyloid cascade
According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).