2,014 search results for “disease prevention” in the Public website
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Joey Zuijdervelt
Science
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Tuomas Aivelo
Science
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Coen van Hasselt
Science
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Microengineered Human Blood Vessels For Next Generation Drug Discovery
Heart failure is a major health care problem with high mortality.
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Innovative strategies to clinically characterize the human tear proteome
Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.
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Clock disruption in diurnal versus nocturnal migrating fish
Does Artifical Light at Night (ALAN) disrupt seasonal physiological and behavioral patterns in migrating freshwater fish?
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Layers of dental tartar
Bacteria in the teeth tell us a lot about nutrition and disease in our ancestors. It also tells us more about the immune system. This provides clues for treating modern diseases and allergies. For a long time archaeologists were irritated by tartar on the teeth of excavated skulls. They thought that…
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Amanda Foks receives Dekker grant from Dutch Hartstichting
Pharmacologist Amanda Foks is one of the ten talented scientists who received a Dekker grant from the Hartstichting. She receives €427,000 to find a way to rejuvenate immune cells to prevent infarcts. Foks was nominated as Discoverer of the Year in 2016.
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Leiden University Medical Center
In the Leiden University Medical Centre (LUMC) we strive to improve health care and the health of people.
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Nitric oxide in defence against mycobacterial infection
Can we enhance the capacity of host immune cells to kill mycobacteria via production of reactive nitrogen species?
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the Social Resilience & Security programme: investigating suicide prevention skills and mental health of Ukraine refugees
The Social Resilience & Security interdisciplinary programme broadens its scope by embedding two research projects lead by Dr. Joanne Mouthaan. The projects adress suicide prevention skills and mental health of Ukraine refugees. Both projects will be integrated in the programme with the aim to improve…
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Topic: Stress and stress-related disorders
The precise psychobiological mechanisms leading to chronic physiological stress responses have not been sufficiently explained, although stress is a major risk factor for disease and early death. A problem for conventional stress theory is that most of these responses seem to occur in situations without…
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Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and
Source: Mol Psychiatry (2015)
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Mycobacterial cell wall-deficiency and its role in the persistence of tuberculosis
What is the role of cell wall-deficiency in the persistence of tuberculosis?
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How could government prevent the next benefits scandal? ‘Be vulnerable and share your data’
Professor Anne Meuwese is calling on governments to show more vulnerability when it comes to providing information about how they function.
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SKY HIGH: Vertical farming a revolution in plant production
As a new vision on food production, the feasibility study on LED light to grow crops with the biological- and chemical evaluation of final products.
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Marker assisted breeding for thrips resistance in tomato
Which plant leaf characteristics are involved in thrips resistance in tomato?
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Horizontal gene transfer and spreading of biosynthetic gene clusters and antimicrobial resistance
Biosynthetic gene clusters (BGCs) for natural products are widespread in microbial genomes, and they are rapidly exchanged. This research assesses the factors that control the spread of BGCs and resistance genes in nature. This includes risk assessment for the spread of engineered DNA in nature.
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Finding a cure for rheumatoid arthritis
Professor Tom Huizinga (LUMC) specialises in rheumatoid arthritis. He joined forces with alumni and the Natuurwetenschappelijk Gezelschap Leiden, a society that aims to share knowledge of the natural sciences and medicine, to explore the symptoms of the disease. With this form of arthritis the fluid…
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Soils2Guts
Steering soil microbiomes for better crop quality: the holy grail to improve human health?
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Vincent Delhomme and Carina Van Os on 'The European Health Union'
On 1 and 2 December 2022, Vincent Delhomme and Carina van Os participated (Europe Institute) in the workshop ‘The European Health Union - Setup, challenges and global outlook’, held at the Max Planck Institute for Comparative Public Law and International Law in Heidelberg. Vincent had the opportunity…
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Frits Rosendaal
Faculteit Geneeskunde
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Annemarie Meijer
Science
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ImageInLife: Training European experts in multilevel bioimaging, analysis and modelling of vertebrate development
How can novel bioimaging technologies and vertebrate model species be used to gain a better understanding of early cellular behaviours with the ultimate goal to increase our understanding of human development and disease processes?
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Topic: Healthy lifestyle: Nudging and self-regulation
We are all aware of the importance of a healthy lifestyle. However, at the same time we also experience many difficulties when we are trying to change our behavior to become more healthy. For example, more often than not our good intentions to exercise more or to eat fewer unhealthy snacks fail miserably…
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Distance-based analysis of dynamical systems and time series by optimal transport
Promotor: S.M. Verduyn Lunel
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Awards and Grants 2024
On this page you will find an overview of awards and prizes granted to our staff and students in 2024, as well as special appointments at Leiden University and other institutions.
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Teeth Tell Tales
A multi-disciplinary approach to past lifestyles and cultural practices
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Chemokine signaling in Tuberculosis and Salmonella infection
Who benefits from CXCR/CXCL chemokine signaling during infection: host or pathogen?
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Topic: Movement and mental functions
Our ability to learn and control movements is essential for engaging in goal-directed behaviour. From buttoning your shirt and driving a car, to cooking dinner and brushing your teeth -- our actions in daily life rely on this ability.
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Zebrafish: a new engraft model to study Ewing sarcoma progression
Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?
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Small changes for long term impact: optimization of structure kinetic properties: a case of CCR2 antagonists
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman
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Photocleavable activity-based acid glucosylceramidase probes
Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…
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Live or let die: the intracellular fate of pathogenic mycobacteria
How do mycobacteria subvert the defenses of host immune cells?
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Development of Comprehensive and High-throughput metabolomics techniques
A major goal of ABS research is to overcome one of the major bottle-necks in metabolomic research: the lack of a high-throughput infrastructure in which thousands of samples can be processed in a standardized and cost-effective way (max. a few tens of Euro’s per sample for a full metabolome profile).…
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Therapeutic intervention to enhance atherosclerotic plaque stability
Proteases degrade matrix molecules in the atherosclerotic plaque, thereby reducing atherosclerotic plaque stability. Mast cells, that contain proteases such as tryptase and chymase, have been identified at the site of rupture in specimens of human coronary arteries and their number in the plaque was…
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The serosa: an evolutionary novelty in insect eggs
What is the function of the insect serosa?
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‘Seeing voices’: the role of multimodal cues in vocal learning
Can birds - like people- ‘see’ voices and learn how to sing by listening and watching?
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Targeted biomolecule production for therapeutic use
We aim to develop a drug-delivery method based on the production of biomolecules directly at the target site.
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MeRGeR: Physiological significance of the glucocorticoid and mineralocorticoid receptor signaling in the innate immune system
Does the mineralocorticoid receptor play a role in the effects of cortisol and synthetic glucocorticoids on the immune response?
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Afrika-Studiecentrum Leiden
Africa has a population of 1.5 billion. In 30 years’ time, this will be 2.5 billion. The continent’s impact on the global economy, but also on the environment, will therefore increase drastically. Researchers from the African Studies Centre Leiden (ASCL) have been aware for decades of the crucial role…
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The quest for new medicines against tuberculosis
Can drug screening for tuberculosis treatment be made more efficient?
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Conquering the fortress: New strategies for the treatment of tuberculosis
Can we exploit the cell death machinery of the host to develop new host-directed anti-TB treatments?
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Influencing your health with your behaviour and thoughts
Psychological processes have a major effect on the course of a disease and the effects of medical treatment. Researchers in the field of Psychoneurobiology examine the interactions between body and mind. They investigate the effects of stress as well as the effect of placebos and nocebos, which can…
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Inkomen en afkomst zijn risicofactoren bij kans op hart- en vaatziekten
Nederlanders met lage inkomens lopen tot 1,5 keer meer risico op het krijgen van een hartaanval of beroerte dan rijkere landgenoten. Bij Surinaamse Hindoestanen is dit risico 1,9 keer hoger. Dat blijkt uit onderzoek van het LUMC en het HagaZiekenhuis. Nederlandse artsen kijken tot nu toe niet naar deze…
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PhD candidate in the field of biochemistry
Science, Leiden Institute of Chemistry (LIC)
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Topic: Stigmatization in patients with chronic health conditions
Imagine that you have a chronic skin condition, characterized by red patches of itchy, scaly skin. You regularly notice people staring at your skin and sense their reluctance to shake your hand. Or imagine that you have Parkinson's Disease, causing your hands to tremble and making it difficult for you…
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Portraits Johan Kuiper and Ilze Bot on Hartstichting.nl
The Heart Foundation has portrayed researchers Johan Kuiper and Ilze Bot of the Leiden Academic Centre for Drug Research (LACDR) who fight heart and brain infarcts in the lab.
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Polar auxin transport: translating environmental signals into plant developmental responses
1. What is the exact role of PIN proteins in PAT? 2. How is PIN polarity established, and how is it modulated by AGC kinase-mediated phosphorylation? 3. What is the role of the AGC kinase, as modulators of PAT, in translating environmental signals, such as gravity, light or mechanical stress, to plant…
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Talk and debate: how do we prevent science from harming the environment?
Sustainability researchers can play an important role in the energy transition. But what if their partners are not (yet) sustainable and science itself has adverse effects? This is the subject of an online talk by researcher Thomas Franssen on 16 December with a discussion afterwards. ‘Clean energy…