On a structural level, the properties featured by a majority of mechanical metamaterials can be ascribed to the finite number of soft internal degrees-of freedom allowing for low-energy deformations.

Mechanical metamaterials are carefully engineered materials whose properties are controlled by their structure, not by their composition, which allows using metamaterials to study and control physical effects in detail⁠.

We investigate the physics and design of mechanical metamaterial, intricately sculpted materials with properties set by their architecture.

Mechanical metamaterials are man-made materials which derive their unusual properties from their structure rather than their composition.

Mechanical metamaterials have been found to display surprising features, on top of their unusual properties such as shape morphing and programmability. When the materials are a step in size larger, new rules seem to apply. This was discovered by researchers at AMOLF and the universities of Leiden and…

In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.

In the first part of this thesis we study the geometry of folding patterns.

Errors are everywhere, and mechanical failures are especially common: buckled grain silos and cracked support columns are, justly, seen as an issue to be avoided.

Researchers from FOM Institute AMOLF, Leiden University and Harvard University made a rubber beam that bends faster when subjected to less pressure. They published their work on 21 July online in Physical Review Letters.

The more complex the object, the harder it is to fold up. Space satellites often need many small motors to fold up an instrument, and people have difficulty simply folding up a roadmap. Physicists from Leiden and Amsterdam have now designed a structure that folds itself up in several steps. Publication…

In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.

Mechanical interactions between cells and their environment play an important role in many biological processes.

Mechanisms fro drug resistance

Promotores: Prof.dr. F.P. Israel, Prof.dr. P.P. van der Werf

We study the physics of a broad range of biological and soft materials

In what ways can a photographic practice act as a means to confront, or even undo, the various material properties of atmospheric enclosure that so clearly put our relationship with our environment under pressure? Is it possible to devise a set of critical and artistic strategies to comprehend the ways…

What is the Fine Mechanical Department?

Bouwmeester

The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.

Promotor: F.P. Israel, Co-Promoter: R. Meijerink

We are interested in understanding the mechanics of soft materials, of which biological materials are prominent examples.

This work describes several studies into the electroreduction of carbon dioxide (CO2RR), both regarding mechanistical aspects and catalyst stability considerations. Mechanistic insights into carbon-carbon bond formation on a silver catalyst are described in Ch 2, were we find an acetaldehyde-like surface…

How do you fit two meters of DNA in a tiny compartment and at the same time are able to access the right parts of it at the right times?

A research into the consumption experience and consumption behaviour.

PhD defence

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

Researchers from Leiden University, the Netherlands, designed a novel metamaterial that buckles on demand. Small structural variations in the material single out regions that buckle selectively under external stress, whereas other regions remain unchanged. The research is published in this week’s Early…

Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska

The applications of studying the early development of insects range from agriculture to material science.

Adverse drug reactions (ADRs) remain one of the major reasons for patient mortality and (early) drug withdrawal. Currently, different in vivo and in vitro models are used to assess the toxic potential of drugs in the pre-clinical phase. Unfortunately, the predictive value of this model does not fit…

To make the right clinical decisions or develop effective diagnostic tests and treatments, it is important to understand the underlying mechanisms of a condition or behavior.

We explore the possibilities to combine magnetic resonance techniques with atomic force microscopy together in a single microscope: the MRI-AFM, also called Magnetic Resonance Force Microscopy (MRFM).

We aim to unravel the molecular mechanisms involved in the transformation of eukaryotic cells by Agrobacterium.

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

Beenakker

This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.

Scientists have developed a material that breaks one of the fundamental principles governing many physical systems. Ordinary materials transmit external forces equally, no matter where the pressure comes from. The newly developed material breaks this rule and could potentially be of interest in soft-robotics…

Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.

Research groups in the Biological & Soft Matter Programme unravel mechanisms in biological processes and develop novel bio-inspired soft materials.

Promotor: M.L. van Hecke

In this project we study the properties of statistical- and rule-learning mechanisms in relation to the acquisition and evolution of language. We ask to what extent these mechanisms are unique to humans - or to human language - by comparing the acquisition of vocal structure in two species: humans (infants)…

Geometric phases lead to a nontrivial interference result when an electron's different quantum mechanical paths choices encircle a magnetic coil in an Aharonov-Bohm experiment.

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

A central and much debated topic in the study of language acquisition concerns the nature of the learning mechanisms that are required. Are the computational and learning mechanisms that guide learning about language structure special and specific to language or humans?

Despite an increased EU role in the preparedness, monitoring and coordination of health emergencies over the past two decades, Member States’ responses to the first wave of COVID-19 were surprisingly uncoordinated. In light of calls to improve cooperation regarding future health emergencies, this article…

My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

Rigid materials break more easily than floppy ones. This simple observation allows to predict and control the width of cracks. Theoretical understanding of how materials break is useful in for example the production of cars or screens. Publication in PNAS.

Promotor: G.P. van Wezel

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa