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In the Drug Research theme, we primarily work with rodents. Rodents, such as mice, are one of the most common laboratory animals. These small mammals are easily housed and exhibit a rapid rate of reproduction.

This project aims to assess the risk of spread of antimicrobial resistance genes in the environment derived from currently used synthetic biology approaches in the field of drug discovery.

Plant Sciences' contribution to the Host-Microbe Interactions research theme is to dissect how microorganisms and microbiomes interact with the plant host and the insects on those plants, and how these insights may be harnessed to improve plant growth and health, by steering microbiome composition and…

Promotor: J.M. Memelink

Promotor: E. Gittenberger, Co-promotor: B.W. Hoeksema

Remko Offringa has been appointed Professor in the field of Plant Developmental Genetics within the Faculty of Science at the Institute of Biology Leiden (IBL) from the 1st of April 2017. Offringa’s research focuses on the role of the plant hormone auxin in controlling plant growth and development,…

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

We aim to unravel the molecular mechanisms involved in the transformation of eukaryotic cells by Agrobacterium.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

Promotor: J.P. Abrahams, Co-Promotor: N.S. Pannu

We describe certain birational modifications of nodal relative curves over a regular base of arbitrary dimension.

The mission of the Plant Sciences cluster is to contribute to the sustainable production of high-quality crops, flowers and high-value bio-based products, and to contribute to the maintenance and restoration of biodiversity in natural ecosystems. This is realised by generating fundamental knowledge…

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The role of language in self-regulation and social behavior in children with an extra X chromosome

We have examined sequences from the ligand-binding domain of the nicotinic acetyl choline receptor (nAChR) in 148 vertebrate species. We are in interested in this receptor because the α-neurotoxins of many venomous snakes binds to this receptor in its location at the neuromuscular junction in all ve…

This project investigates the role of art in the public and academic debate on biosolar energy

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

Lions in West and Central Africa form a unique group, only distantly related to lions in East and Southern Africa. Biologists at Leiden University confirm this in an article published in Scientific Reports.

Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.

This longitudinal study is focused on neurodevelopmental problems in young children with XXY, XXX and XYY, aged 1 to 6 years.

A mere day after setting foot ashore in the Bahamas on October 13th 1492, Christopher Columbus notes the broad foreheads of the inhabitants of the Americas. These permanently altered cranial shapes are deliberately created through the application of pressure to the head of the infant in the first years…

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

Oxidation is a common degradation pathway that affects therapeutic proteins and peptides during production, purification, formulation, transportation, storage and handling of solid and liquid preparations. In the present work we review the scientific literature about structural and biological consequences…

Diacylglycerol lipases (DAGLα and DAGLβ) are responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain and peripheral tissues. Selective DAGLβ inhibitors have been proposed as a potential treatment for inflammatory diseases with reduced potential for central…

Lecture, This Time for Africa! Series

This dissertation investigates whether and how gradability is manifested in the nominal domain, as well as the implications this could have for theories of the representation of gradability.

This thesis investigates the syntax of object marking in Sambaa and the Bantu languages in general, with particular focus on Swahili and Haya, as points of comparison.

Promotores: J. Jonkers, K.E. de Visser

Brain development in children with an extra X chromosome as compared to children with autism: evidence from MRI

Social anxiety runs in families, but the neurobiology underlying this genetic vulnerability is until now largely unknown. The unique Leiden Family Lab study on Social Anxiety Disorder (LFLSAD) aims to broaden our knowledge with respect to this genetic susceptibility.

PhD defence

The aim of the project is to unravel the genetic and contact relations between the indigenous languages of Mesoamerica (Mexico and western Central America) and the Middle Andes region (Ecuador, Peru, Bolivia), as part of a larger endeavor to understand the historical process of the peopling of the Americas…

We have developed a microfluidic platform for complex 3D organotypic cell cultures (so-called organ-on-a-chip systems) which are suited for integration in 96 or higher well plate format.

Evolution & Biodiversity is one of the four research themes of the Institute of Biology Leiden.

Lecture

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

From basic science to real-world interventions