In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

How can zebrafish models be used to gain a better understanding of host-pathogen interaction mechanisms and to screen new drugs for infectious disease treatment?

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

How do we address the pressing challenges posed by large-scale networks?

Modelling supra-regional communities in the early 3rd Millennium BC

The Leiden Complex Networks Network (LCN2) aims at bringing together scientists from different disciplines, based on a common interest in both theoretical models and empirical analyses of networks and graphs.

Can the (industrial) herbal extraction process be mathematically described and can this model be used to optimize the extraction in terms of quality and economical parameters?

The recent terrorist attacks in Europe are presumably not just acts committed by individuals, but acts facilitated by larger jihadist networks. But how do such networks operate? Understanding their modus operandi can be useful knowledge to counter terrorist threats.

Mathematical models of software systems enable characterizations, abstractions, simulations, and analysis of complex software during its development.

We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.

This dissertation consists of two parts, with the common theme

Promotor: Prof.dr. E. Deprettere

This dissertation studies how domestic regulatory agencies and the officials representing them are influenced by and deal with the increasingly complex transnational environments in which they have come to operate. Based on (social) network analysis it demonstrates how decisions of domestic agencies…

Promotor: E.F.A. Deprettere, Co-Promotor: A.C.J. Kienhuis

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Promotor: Roeland M.H. Merks

For many system in statistical physics the microcanonical and canonical ensemble are equivalent in the thermodynamic limit, but not for all.

Promotor: A.W. van der Vaart

The Leiden Leadership Centre is an international and interdisciplinary network organisation connecting people and perspectives.

Existing work in probabilistic language modeling can be mostly divided into two categories:

Below you can find lists of Leiden-based and international organizations working on Central Asia, and an overview of useful resources on Central Asia.

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

The ‘Food citizens?’ project is assisted by an advisory board, consisting of academics and stakeholders.

In 2016, Dutch University Medical Centres (UMCs) developed the self-evaluation tool based on the PhD Competence Model. Our partners at Utrecht University are making a digital version of the tool available free of charge for our PhD candidates at Leiden University, including for candidates who are not…

LeiCenSAA is dedicated to the study of Ancient Arabia and the sharing of knowledge and expertise on this topic. Thefore it aims to collaborate closely with other research in the field.

The Leiden University Sustainability Network is the platform for Leiden University staff and students to combine their efforts and support each other in making our university more sustainable.

The LGBT+ Network offers a platform for all lesbian, gay, bisexual, transgender and queer staff and students at Leiden University.

The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

Main challenges in skin vaccination are overcoming the stratum corneum (SC) barrier and targeting the antigen presenting cells (APC) in the epidermis and the dermis.

Arts and leisure, Arts and leisure

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar-Jagalska

The focus of this programme is the inter-community social relationships and transformations of island networks in the Lesser Antilles across the historical divide.

Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.

This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.

Both within Leiden University and in the external partner universities PhD research is conducted which is directly or indirectly related to regional integration.

Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.

Below you can find an overview of our network.

This research team is concerned with the measurement and modelling of behaviour, cognition, and unobserved traits (e.g., latent variables, missing data). Central aims include the distillation of a complex set of features into lower-dimensional representations (e.g., factor analysis, IRT), determining…

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

We study the structure, dynamics and physics of complex networks emerging from the intricate interconnectedness of the constituents of large systems.

How and under what conditions Dutch primary school principals' managerial networking activities affect the performance of their school

LIAS researchers working in the field of linguistics hold dual appointments in LIAS and the Leiden University Centre for Linguistics (LUCL).

In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.