1,189 search results for “anti-cancer drug steen” in the Public website
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Participants
The CIGR comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC), the Leiden Academic Centre for Drug Research (LACDR) and the Leiden Institue of Physics (LION).
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Computational modeling of tumor growth and metastasis and the role of the immune system in tumor destruction
In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.
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C.J. Kok Jury Award for Thesis of the Year
Isotopes on exoplanets, a more efficient memory for data centres or new molecules that work against the Zika virus and HIV. Which PhD candidate has written the most impressive dissertation of 2023? The jury of the C.J. Kok Jury Award faces the challenging task of deciding that. Meet the nominees of…
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Leiden Institute of Chemistry
The chemical industry must continue to innovate for a more sustainable, healthier society. The reseachers from the Leiden Institute of Chemistry (LIC) contribute by applying their knowledge to themes such as sustainability, energy and health.
- Admission & Application
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Governance of Violence (MSc)
What is the nature and scope of violence? Who offends, and in what context? Who are the victims? And how can we design suitable intervention and prevention strategies? In this track, you will be familiarised with the many faces of violent offending, to provide the knowledge and tools to understand,…
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Brand-new professor Gerard van Westen wants to cross boundaries
Brand-new professor Gerard van Westen works at the intersection of artificial intelligence and drug development. For the new chair in Artificial Intelligence and Medicinal Chemistry, he uses computer models to make drug development more efficient. Our ultimate goal is a virtual human which allows you…
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Improving painkiller dosing in the clinic
Children, cardiac surgery patients or people who are obese. How can we improve the dosing of painkillers for these patients? Hospital pharmacist Sjoerd de Hoogd of the St. Antonius Hospital in Utrecht investigated this. He combined data from the hospital with the knowledge and expertise of the Leiden…
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Chinese herbal plants in the Hortus botanicus of Leiden University
Education in (Chinese) Medicinal Plants associated to the Hortus botanicus in Leiden - Which Traditional Chinese Medicinal plants can be grown in the Hortus? - Establishing of a database which Chinese medical plants are available in Dutch Botanical Gardens - Data validation (correct identification,…
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Anisotropy, multivalency and flexibility-induced effects in colloidal systems
We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.
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Ukraine
This is an Erasmus+ International Credit Mobility project of the Faculty of Sciences with one partner in Ukraine.
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Bio-Pharmaceutical Sciences
PhD candidates carry out a programme of independent research and additional limited) course work, culminating in production of a PhD thesis in typically 4 years.
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Human skin equivalents: understanding the lipid biosynthesis in the skin
There is considerable need for improved skin models to develop safe and efficient drugs for skin delivery as well as for cosmetic and chemical product testing on the skin.
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Indanes-Properties, Preparation, and Presence in Ligands for G Protein Coupled Receptors
The indane (2,3-dihydro-1H-indene) ring system is an attractive scaffold for biologically active compounds due to the combination of aromatic and aliphatic properties fused together in one rigid system.
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Discovery of BUB1 kinase inhibitors for the treatment of cancer
The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.
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Rob van der Heijden
PhD at Leiden University and Bruker - the Netherlands
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In Pursuit of Next-Generation Lipopeptide Antibiotics
Can new variants of daptomycin and the polymyxins be found?
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Support Departments
List of Support Departments at LION and the Faculty of Science
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Photothermal studies of single molecules and gold nanoparticles: vapor nanobubbles and conjugated polymers
Promotor: M.A.G.J. Orrit
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Systems dermatology of inflammatory diseases
Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…
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Institutes
Leiden University research institutes based in Leiden and The Hague.
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A community computational challenge to predict the activity of pairs of compounds
Source: Nat Biotechnol, Volume 32, Issue 12, pp. 1213-22 (2014)
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Oxidation of Therapeutic Proteins and Peptides: Structural and Biological Consequences
Oxidation is a common degradation pathway that affects therapeutic proteins and peptides during production, purification, formulation, transportation, storage and handling of solid and liquid preparations. In the present work we review the scientific literature about structural and biological consequences…
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The road to insurmountability: Novel avenues to better target CC Chemokine receptors
This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.
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Sentencing in the Netherlands : taking risk-related offender characteristics into account
The sentencing decision of the judge might be the most important decision in the criminal proceedings, not only because of the impact the punishment has on the offender, but also because the sentencing decision is a cornerstone of the legitimacy of the entire criminal justice system.
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Development of personalized health monitoring using ultra-weak photon emission based on systems medicine concepts
Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk
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New polymyxin antibiotics for old problems: addressing nephrotoxicity and resistance
Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…
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The good? The bad? The mutant! Characterization of cancer-related somatic mutations and identification of a selectivity hotspot in adenosine
G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.
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Pharmaceutical Aspects of Subvisible Particles in Protein Formulations
Promotor: W. Jiskoot, Co-promotor: A. Hawe
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Novel Immune Cell-Based Therapies for Atherosclerosis
Promotor: Prof.dr. J. Kuiper, Co-Promotor: S.C.A. de Jager
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Predicting crime in dark web forum networks
In this project, we use social network analysis to analyze the behavior of users in online forums and associated marketplaces over time.
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Innovative analytical approaches for protein aggregates and other particulate matter impurities
Developing robust and comprehensive analytical methods to size and quantify subvisible particles in biopharmaceutical products.
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Templates
To achieve a more consistent and professional look in our scientific posters. A new template has been chosen. This design and its principal elements can be downloaded here.
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A large-scale crop protection bioassay data set
ChEMBL is a large-scale drug discovery database containing bioactivity information primarily extracted from scientific literature.
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Bioengineering and biophysics of viral hemorrhagic fever
Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…
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Squaramide-based supramolecular polymers: from self-assembly to in vivo application
The aim of this thesis is to develop and study a robust and adaptable scaffold for supramolecular polymer self-assembly in water.
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CAM-PaC
The overall aim of CAM-PaC is to contribute to solving the socioeconomic and health challenges of PDAC by an integrative and systematic functional analysis of pancreatic cancer candidate genes. CAM-PaC will develop novel cellular and animal models, as well as novel strategies to analyse and integrate…
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Dynamics of the renin-angiotensin aldosterone system in dogs: circadian variations in physiological conditions and in relation to angiotensin-converting
Promotor: Prof.dr. M. Danhof
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Automated de novo metabolite identification with mass spectrometry and cheminformatics
Promotor: Prof.dr. T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier
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NO-ESKAPE New Strategies for Overcoming the ESKAPE Pathogens
Natural product inspired antibiotics to address resistance
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Coiled-coil mediated liposomal fusion: Asymmetric behaving peptide fusogens
Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.
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Predicting early Alzheimer's disease stage in human
A new research line is the development of liquid biopsy fingerprints to predict early Alzheimer’s disease (AD) stage in human in readily accessible body fluids in human (in collaboration with: Dr. Geert-Jan Groeneveld, CHDR; Prof. Elga de Vries, Free University Medical Center; and others).
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Exploring chemical space in covalent and competitive glycosidase inhibitor design
Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency
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Teris van Beek
Dr. at the Department of organic chemistry, Wageningen University - the Nederlands
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In vitro model systems for studying the impact of organic chemicals on the skin barrier lipids
This paper describes two synthetic lipid models designed to replace human stratum corneum (SC) in studies of the impact of volatile organic chemicals on the molecular organization of the skin barrier lipids.
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Key publications
Key publications of the Analytical BioSciences and Metabolomics group
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Chemical tools to study lipid signaling
Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.
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Leiden Bio Science Park
At Leiden Bio Science Park (LBSP) Leiden University works together with the business community, the LUMC and the Municipality of Leiden.
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Selective autophagy in host defense against mycobacterial infection
The effective treatment of tuberculosis (TB) remains a major challenge to global health.
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Mathematical analysis of systems pharmacology models
Systems pharmacology aims to apply techniques from systems biology to pharmacological models.