At the division of Biopharmaceutics, we aim to develop and test new therapeutic approaches to limit or even prevent the development of atherosclerosis in order to reduce the number of acute cardiovascular syndromes such as myocardial infarction or stroke.

In the future, physicians may be able to identify dementia much earlier than they can today because a computer algorithm will be able to predict from brain scans how our memory is going to develop.

How can zebrafish research help to understand and fight human cancer?

Can we bring novel treatment options to the clinic for UM patients with liver metastases?

The programme of the 3rd International Workshop on Klinefelter Syndrome, Trisomy X, and XYY. International Workshop theme: 'A life-course perspective'

What is the role of auxin in the initiation and process of somatic embryogenesis?

PBDL favors multidisciplinary research. Depending on the problems under investigation, PBDL establishes collaborations between experts from for example molecular genetics, molecular and electro cell physiology, biochemistry, organic chemistry, analytical mathematics, mathematical statistics and computational…

Research aims: Identification of key genes involved in programming the cellular architecture of A. niger & Genetic engineering of A. niger in order to improve its secretory capacities and rheological behavior under industrial fermentation conditions.

We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.

What distinguishes a tumour cell from a healthy cell? Researchers are trying to answer this question as precisely as possible. Certain differences could eventually lead to new therapies.

The research programme Probability Theory focuses on probability theory and on operations research.

Research lines within the Pharmacy group:

The recognition that there may be more, so-called allosteric binding sites on a given receptor has also fueled our synthetic efforts. Over the last few years we have focused on many drug targets (adenosine A1, A2A and A3 receptors, the mGlu2 receptor and a classic ‘anti-target’, the hERG channel) to…

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

Promotores: H.A. Udo De Haes, P.M. Brakefield

Do large deletions represent a risk during CRISP/CAS9-mediated genome editing in plants?

Promotores: A.H. Meijer, H.P. Spaink

Promotor: Prof.dr. E.F. Smets, Co-promotores: Dr. B. Gravendeel, F. Pupulin

The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

Promotor: Roeland M.H. Merks

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

Aim of the proposal is to develop lugdunomycin into a drug candidate able to treat infectious diseases caused by multi-drug resistant pathogens.

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

Currently, several successful vaccines are available. However, for pathogens with a highly variable genetic composition, and for which serum IgG antibodies are not a useful correlate of protection, effective vaccines are yet to be developed.

What is the role of neuronal emotional reactivity in the intergenerational transmission of abuse?

Can the pink-pigmented microbe Methylobacterium extorquens be genetically engineered to convert the sustainable raw material methanol into antibiotics?

Promotor: B. van de Water, Co-Promotores: J.H.N. Meerman, F.J. Verbeek

We aim to develop a drug-delivery method based on the production of biomolecules directly at the target site.

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

The overall aim of CAM-PaC is to contribute to solving the socioeconomic and health challenges of PDAC by an integrative and systematic functional analysis of pancreatic cancer candidate genes. CAM-PaC will develop novel cellular and animal models, as well as novel strategies to analyse and integrate…

Migration is the talk of the town. On the whole, however, the current situation is seen as resulting from unique political upheavals. Such a-historical interpretations ignore the fact that migration is a fundamental phenomenon in human societies from the beginning and plays a crucial role in the cultural,…

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

Psycho-physiological reactions to stress.

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

Promotor: Prof.dr. T. Schmidt, Co-promotor: Dr. ir. S. J.T. van Noort

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

Host-Microbe Interactions is one of the four research themes of the Institute of Biology Leiden.

Reconstructing language history and prehistory in the context of the Indo-European language family.

Although there has been an increase in the research into brain function and dysfunction in relation to stress and emotions, there are still many unanswered questions.

Promotor: G.P. van Wezel

The Horizon 2020 project CoSTREAM aims to improve our understanding of the co-occurrence of stroke and Alzheimer’s disease. It has long been known that both diseases share underlying causes, but their exact interaction or link is not fully understood. CoSTREAM combines multiple factors to identify and…

Promotor: Prof.dr. P.G.L. Klinkhamer, Co-Promotor: T.J. de Jong

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

Promotoren: G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)

Where did species survive the cold cycles of the current Ice Age?

What is the role of the noradrenergic system in human cognition?

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

The CMCB brings together a diverse range of unique expertise in microbial cell biology. Members of the CMCB investigate both model and non-model organisms, bacteria and archaea, pathogens and non-pathogens.