Nature, nurture and neural mechanisms of social emotion regulation in childhood

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

Kunst en vrije tijd, Kunst en vrije tijd

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

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Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

This thesis describes how different colours of light affect various aspects of the growth and development of Arabidopsis and tomato plants⁠.

Onderzoekers van het LUMC hebben, in samenwerking met de TU Delft, een manier gevonden om een op hol geslagen hart, automatisch en direct te resetten met een geïmplanteerd LED-lampje.

Welke factoren (mens-dimensie en carnivoor-gerelateerd) zijn bepalend voor de menselijke tolerantie ten opzichte van grote carnivoren en voor de overlevingskansen van grote carnivoren in bossen met meervoudig gebruik?

The focus of this thesis is how stars like our Sun and planets like Jupiter, Saturn, and Earth are formed.

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

In recent decades, climate change has led to more frequent and severe drought events, causing serious consequences such as increased forest mortality and significant crop yield losses. Understanding how drought affects plants, especially economically important herbaceous species, is crucial for predicting…

This thesis discusses the discovery potential of Intensity Frontier experiments.

Cyclic peptides are investigated as a platform to induce different orientations between various ligands.

Promotor: Prof.dr. M. de Jong, Co-Promotor: A.J. Heijboer

Een bachelor Security Studies doen en tegelijkertijd twee bedrijven opzetten en runnen: student Mohamed Sulaiman is altijd aan het werk. Maar dat doet hij met plezier en toewijding. Bij ondernemershub PLNT Den Haag krijgt hij hulp en doet hij inspiratie op.

How can we, together international experts, define future needs of R+D contributions for innovations in the field of risk-based management of chemicals and products in a global perspective using alternative testing strategies to minimize animal tests?

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

Grensverleggend geschiedenis leren.

The energy system is at the heart of two of the greatest challenges of the 21st century: decreasing CO2 emissions to meet the ambitions of the Paris agreement while fulfilling the growing energy demand associated with the economic aspirations of a growing world population.

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

This thesis focuses on the social dimensions of crane and wetland conservation in rural landscapes in Kenya, Uganda and Zimbabwe.

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

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CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

Graduation MIRD Class of 2024: 'The world is better off with students like this'

This study has been carried out in the community of Sukamiskin, a kelurahan (‘village’) in Bandung, the Capital of West Java Province, located in the Sunda Region of Indonesia.

The main theme of this thesis is the theoretical study of Gaussian processes as a tool in Bayesian nonparametric statistics.

Promotor: Erik F. Smets, Co-promotores: Barbara Gravendeel, Niels Raes

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Tijdens de ontwikkeling van de Humanities Campus komen veel aspecten van duurzaamheid samen. Denk bijvoorbeeld aan:

The thesis explores how interstellar chemistry evolves as a function of time and changing physical architectures during the formation of stars.

Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).

Carbohydrates, or sugars, are the most diverse and most abundant biomolecules known. However, the isolation of carbohydrate samples in sufficient amounts and purity is often impractical or even impossible, so the chemical synthesis of glycosides becomes relevant. The glycosylation reaction, in which…

Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.

In deep reinforcement learning, searching and learning techniques are two important components. They can be used independently and in combination to deal with different problems in AI, and have achieved impressive results in game playing and robotics. These results have inspired research into artificial…

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HEPGAME is a research project that combines the world’s fastest computer algebra system for High Energy Physics equations, FORM, with insights from artificial intelligence. The name combines High Energy Physics and Games.

Can we develop a platform for raw materials intelligence?

In the CarbonCap project, consumption oriented technological options and policy measures are identified as an addition to the present EU and world climate policy.

Promotor: Prof.dr. I.A.G. Snellen, C.U. Keller

Large carnivore population is globally declining as a result of the fragmentation of habitat, large prey depletion and retaliatory killing by pastoralists.

Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen