Op 8 januari 2020 verdedigde Jelmer Brouwer zijn proefschrift 'Detection, detention, deportation'. Het promotieonderzoek is begeleid door promotoren prof.dr. J.P. van der Leun en prof.dr. M.A.H. van der Woude.

Structural variants (SVs) are the hidden architecture of the human genome, and are critical for us to understand diseases, evolution, and so on.

Promotor: Prof.dr. E. Eliel, Co-Promotor: M.J.A. de Dood

Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.

Promotor: E. Bouwman, Co-Promotor: S. Bonnet

Promotor: I. Snellen, Co-Promotor: M. Kenworthy

Detecting nanoscopic objects plays an important role in nanoscience in particular, in the rapidly growing field of nanobiology. The forebear to modern super-resolution microscopy for single molecule investigation, is fluorescence microscopy.

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

How do nanoparticles bioaccumulate and biodistribute in organisms?

Transport inspectorates are looking for novel methods to identify dangerous behavior, ultimately to reduce risks associated to the movements of people and goods. We explore a data-driven approach to arrive at smart inspections of vehicles.

Promotor: A.W. van der Vaart

Promotor: Prof.dr. J.N. Kok, Co-promotor: A.J. Knobbe

Promotores: Prof.dr. D. Bouwmeester, Prof.dr. A. Fiore (TU Eindhoven)

Promotie

In this work, we attempt to answer the question:

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

Promotie

The first direct detection of gravitational waves opened the possibility of mapping the Universe via this new and independent messenger.

In this PhD-thesis several new and existing data science application are described that are particularly focused on applications for tax administrations.

This thesis aims to improve the detection from ultra-weak single emitter by enhancing their emission properties with plasmonic nanostructures. We exploit the wet-chemically synthesized single crystalline gold nanorods (GNRs) as our basic frameworks in the whole studies, simply because of their unique…

Promotie

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

Understanding the formation and evolution of planetary systems is one of the most fundamental challenges in astronomy. To directly image and study young exoplanets and the circumstellar disks they form from, dedicated high-contrast imaging instruments are built.

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.

As a non-invasive genetic method, eDNA based approaches have become an important component of ecologists' and environmental managers' toolkits for biomonitoring in conservation and an increasingly important source of ecological knowledge.

Tracing the evolution of the molecular gas content in galaxies is critical for a complete understanding of galaxy formation and evolution, as it provides the direct fuel for star formation. Studies of high-redshift (z>1) molecular gas reservoirs, most commonly traced by carbon monoxide (CO), have seen…

Promotie

Promotie

Promotie

Promotor: M.A.G.J. Orrit

Promotor: H.J.A. Röttgering, Co-promotor: G.K. Miley

In this thesis chemical and physical processes in the ice mantles on interstellar dust grains are studied.

Gold nanoparticles show surprisingly strong interactions with light in the visible range, which can be divided into scattering, absorption, and photoluminescence.

With the emergence of online social networks (OSNs), the way people create and share information has changed, which becomes faster and broader than traditional social media.

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

Promotie

Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)

LiDAR is een relatief nieuwe meettechniek waarmee het Actueel Hoogtebestand Nederland het hele land zeer nauwkeurig mee heeft ingemeten. Het grote voordeel van deze manier van meten is dat vegetatie geen belemmering vormt. Hierdoor kunnen ook gebieden waar vegetatie de zichtbaarheid van de ondergrond…

In this thesis, we describe the latest advances in SQUID-detected Magnetic Resonance Force Microscopy (MRFM).

Promotor: Prof.dr. H.J.A. Rottgering

Majorana fermions in superconductors are the subgap quasiparticle excitations that are their own antiparticles.

Promotor: Prof.dr. T. Hankemeier

With the dramatic growth of the image data on the web, there is an increasing demand of the algorithms capable of understanding the visual information automatically.

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

We explored how to morphologically classify well-resolved jetted radio-loud active galactic nuclei (RLAGN) in the LOw Frequency Array (LOFAR) Two-metre Sky Survey (LoTSS) using machine learning.

This thesis focuses on protoplanetary disks: flattened structures of gas and dust around young stars in which planets are expected to form and grow.

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

Promotor: Prof.dr. I.A.G. Snellen, C.U. Keller

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.