1,691 zoekresultaten voor “is a and petra” in de Publieke website
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Structural and functional analysis of proteins involved in natural product biosynthesis and morphological differentiation in Streptomyces
Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.
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Integrating cellular and tissue dynamics with cell fate decisions through computational modeling
There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…
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Lipid mediated colloidal interactions
The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.
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The dust and molecular gas in the torus of NGC 1068
An Active Galactic Nucleus (AGN) is a highly luminous region at the center of a galaxy, powered by the accretion into a supermassive black hole and emitting energy from radio waves to gamma rays, often outshining the host galaxy.
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Microengineered Human Blood Vessels For Next Generation Drug Discovery
Heart failure is a major health care problem with high mortality.
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Cheating belowground interactions
Mycoheterotrophy is a particular mode of life in which plants obtain carbohydrates from their associated fungal partners, instead of by using photosynthesis.
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Many objective optimization and complex network analysis
This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.
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B cell modulation in atherosclerosis
Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.
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Cathodic corrosion
Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.
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Coiled-coil mediated liposomal fusion: Asymmetric behaving peptide fusogens
Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.
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Glucocerebrosidase and glycolipids: In and beyond the lysosome
The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.
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Balsaminaceae in Southeast Asia: systematics, evolution, and pollination biology
Balsaminaceae is a diverse plant family characterized by a huge floral morphological diversity.
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Mitochondria in chemical-induced toxicity
Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…
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Chemical genetic approaches for target validation
Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.
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Gibbs Processes and Applications
Gibbs measures, as used in Statistical Mechanics, have a definition that is remarkably similar to the definition ofg-measures, used in dynamical systems.
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Methods and Tools for Mining Multivariate Time Series
Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.
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Synthesis of Ribitol Phosphate based Wall Teichoic acids
Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.
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Intense automorphisms of finite groups
In this thesis we classify the pairs (p,G), where p is a prime number and G is a finite p-group possessing an intense automorphism, i.e. an automorphism that sends each subgroup of G to a G-conjugate, that is non-trivial and whose order is coprime to p.
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Computational optimisation of optical projection tomography for 3D image analysis
Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.
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Semigroups on Spaces of Measures
Promotor: S.M. Verduyn Lunel, Co-promotor: S.C. Hille
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Synthesis of oligosaccharide libraries from GBS capsular polysaccharides for structure-based selection of vaccine candidates
Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.
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Data-driven Predictive Maintenance and Time-Series Applications
Predictive maintenance (PdM) is a maintenance policy that uses the past, current, and prognosticated health condition of an asset to predict when timely maintenance should occur.
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Exploring novel regulators and enzymes in salicylic acid-mediated plant defense
Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.
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Trans-kingdom DNA transfer
The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.
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Reactivity and Selectivity in Glycosylation Reactions
The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.
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Discovery and exploitation of the transcriptional regulatory system of pectinases in Aspergillus niger
Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.
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Workshop The Art of Journaling
Kunst en vrije tijd, Kunst en vrije tijd
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Genomics applications of nanopore long-read sequencing for small to large sized genomes
In this thesis I highlight the applications of Oxford Nanopore Technologies (ONT) sequencing. This technique is a relatively new approach in the sequencing field, where nanopores are embedded in a membrane, DNA molecules are pulled through nanopores and an electrical current serving as the sequencing…
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Ecological functions and environmental fate of exopolymers of Acidobacteria
Acidobacteria is a widely distributed phylum but their functional roles in ecosystem processes are still largely elusive.
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The parabolic Anderson model on Galton-Watson trees
The parabolic Anderson model (PAM), which is the Cauchy problem for the heat equation with random potential. The PAM is a mathematical model that describes how mass (i.e. matter or energy) flows in a medium in the presence of a field of sources and sinks.
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Call for Papers and Panels: Global Transformations and Governance Challenges (GTGC) Conferentie 2022
Van 8-10 juni 2022 organiseert Global Transformations and Governance Challenges (GTGC) haar eerste internationale conferentie in Den Haag. Deadline voor inzendingen: 22 april 2022.
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The Duke-Leiden Institute in Global and Transnational Law: Call for Applications 2019
The Grotius Centre, in collaboration with Duke Law School, will be hosting the Duke-Leiden Institute in Global and Transnational Law from 16 June to 17 July 2019 in The Hague, the International City of Peace and Justice. Applications for the second edition are now open!
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Capillary Electrophoresis-Mass Spectrometry based Metabolomics Approaches for Volume-restricted Applications
Metabolomics is a powerful tool that can provide a comprehensive insight into the complexity of human biology and the pathophysiology of diseases. By analyzing the metabolome, which refers to the complete set of small (endogenous) molecules (with a mass <1500 Da) present within a given biological system,…
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The LUGO Press
The LUGO Press is a student publication forum, rooted in academia and journalistic practices and published by the Leiden University Green Office.
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Online Course Clinical Kidney, Pancreas and Islet Transplantation
Kidney transplantation is a major advance of modern medicine. This course will give you state of the art updates about what used to be an experimental, risky, and very limited treatment option more than 50 years ago and is now routinely performed in many countries worldwide.
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Tien jaar Life Science and Technology
Op 9 september 2009 viert de opleiding Life Science and Technology (LS&T) haar tienjarig bestaan.
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Krijgsgeweld en kolonie. Opkomst en ondergang van Nederland als koloniale mogendheid 1816-2010
Dit recent verschenen boek analyseert en verklaart de opkomst en ondergang van Nederland als koloniale mogendheid vanuit militair perspectief.
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representation: An experimental study on teacher-student gender congruence and students’ perceived abilities in math
Onderzoek naar representatieve bureaucratie heeft vaak de positieve prestatie-effecten bevestigd van bureaucratieën die de demografische kenmerken van hun cliënten weerspiegelen. Er is echter weinig bekend over de onderliggende mechanismen op individueel niveau die tot deze resultaten leiden.
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Mattijs Numans
Faculteit Geneeskunde
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Antonius Johannes Rabelink
Faculteit Geneeskunde
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Inge Ligtvoet
Faculteit der Geesteswetenschappen
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Liwen Meng
Faculteit der Sociale Wetenschappen
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Peter van der Zwan
Faculteit Rechtsgeleerdheid
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Peter de Knijff
Faculteit Geneeskunde
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Nadia Garnefski
Faculteit der Sociale Wetenschappen
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Tommy van Avermaete
Universitaire Bibliotheken Leiden
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Alies Jansen
Faculteit der Geesteswetenschappen
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Abdourahamane Idrissa Abdoulaye
Afrika-Studiecentrum
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Susan van den Brink
Wiskunde en Natuurwetenschappen
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Universe Awareness’ Universe in a Box wint prijs Beste Lesmateriaal voor Wetenschapseducatie
Universe in a Box is erkend voor zijn educatieve waarde, door het Europese netwerk van Wetenschapseducatie (Scientix).