The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

De tweede, geactualiseerde druk van dit boek belicht de organisatie en het functioneren van de brandweer en brandweerzorg. In drie delen beschrijven wetenschappers en practitioners de turbulente ontwikkelingen van de afgelopen tien jaar, zoals de verbreding naar rampenbestrijding. Erwin Muller, hoogleraar…

Dit is een Virtual Reality onderzoek naar de veiligheid van woonwijken. Hiervoor hebben de afgelopen maanden 200 gedetineerden meegewerkt aan dit onderzoek en nu willen we graag ook 200 mensen uit de maatschappij uitnodigen mee te doen met dit onderzoek.

This dissertation combines the use of defined microenvironments, high-resolution fluorescence microscopy, and time-resolved analysis, to study intracellular and cellular motility.

Astronomical observations of cold regions in the universe show a rich inventory of ices. Part of these ices may end up on planets like our own, but in that journey they will be exposed to considerable amounts of radiation.

Ons onderwijsaanbod is breed en divers. Hieronder vindt u alle informatie over de vakken die door de afdeling Bedrijfswetenschappen worden verzorgd. Als u op een vak klikt, wordt u doorgeleid naar de studiegids.

In this work, we investigate the minute circular dichroism effects of single nanoparticles.To this aim, we apply photothermal imaging with a polarization-modulated heating beam.

Het onderzoek van de Intelligence and Security Studies Group naar inlichtingen en veiligheid draagt bij aan academische kennis, voedt de publieke discussie, ondersteunt ons onderwijs en de ontwikkeling van professionele praktijk.

Bereid je voor op de MSc Nationalism, Ethnic Conflict and Development aan Universiteit Leiden met oriëntatieprogramma’s, studiebronnen, visumondersteuning en studentenbegeleiding.

Ontdek hoe je je kunt voorbereiden op de masteropleiding The Politics of Artificial Intelligence aan de Universiteit Leiden: oriëntatieactiviteiten, academische bronnen, visumadvies en studentenondersteunende diensten.

Bereid je voor op de MSc Political Theory: Legitimacy and Justice aan Universiteit Leiden met oriëntatieactiviteiten, studiebronnen, visuminformatie, studentenondersteuning en praktische aankomsttips.

Why do sexual violence policies still fail to systematically address men and masculinities, when the need for cultural change among men has been central in public debates since #MeToo?

The dissertation offers new tools and insights to computation and modelling of topological phases, with an emphasis on the aperiodic setting.

Material circularity and energy efficiency are highly relevant and intertwined issues for the transition towards a carbon-neutral and circular built environment. In the Netherlands, the building sector has been rendered a priority towards a circular and low-carbon society.

It is an established fact that the Standard Model has to be extended to explain the so-called Beyond the Standard Model (BSM) phenomena: dark matter, matter-antimatter asymmetry of the Universe and neutrino flavour oscillations.

Zoë van de Kerkhof is de stadsdichter van Leiden. Speciaal voor het 450-jarig bestaan van de universiteit schreef zij een gedicht.

De Universiteit Leiden gaat als eerste universiteit in Europa samenwerken met de Asian Development Bank (ADB). De Aziatische ontwikkelingsbank wil meer een 'klimaatbank' worden, Leiden gaat daarbij helpen met onderzoek en onderwijs.

Promotor: Prof.dr. A.G.G.M. Tielens

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

The thesis explores how interstellar chemistry evolves as a function of time and changing physical architectures during the formation of stars.

This thesis is an experimental study of the UV irradiation of the interstellar ice analogues, relevant for the different stages of the star and planet formation sequence.

In this thesis I describe the results of Pulsed Interleaved Excitation and Fluorescence (Cross) Correlation Spectroscopy (PIE-F(C)CS) combined with single-pair Förster Resonance Energy Transfer (spFRET) used to study dynamics in single nucleosomes, which depends on subtle differences in the length of…

Lezing

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

Onderzoek naar representatieve bureaucratie heeft vaak de positieve prestatie-effecten bevestigd van bureaucratieën die de demografische kenmerken van hun cliënten weerspiegelen. Er is echter weinig bekend over de onderliggende mechanismen op individueel niveau die tot deze resultaten leiden.

Op 12 september 2019 verdedigde Michiel Rhoen zijn proefschrift 'Big Data, Big Risks, Big Power Shifts: Evaluating the General Data Protection Regulation as an instrument of risk control and power redistribution in the context of big data'. Het promotieonderzoek is begeleid door promotoren prof.dr.mr.…

Learning a programming language is challenging. Even one of the first –but crucial– concepts to learn, variables, is hard to grasp. Variables can represent different roles and functions within a code and need to be named appropriately to support code comprehension and debugging.

Deze colleges zijn in het Engels, u kunt vragen stellen en reageren in het Nederlands.

Waarom is er geen Noordoost Aziatische veiligheidsstructuur? In dit artikel, gepubliceerd in The Pacific Review, bespreken auteurs Wang (Peking University) en Stevens (Leiden University) de vier obstakels voor coöperatie in Oost Azië.

De Engelstalige bacheloropleiding Urban Studies ging dit jaar van start, maar wat houdt de opleiding precies in? André Gerrits, hoogleraar International Studies and Global Politics, was te gast bij Sleutelstad om te spreken over deze nieuwe opleiding.

Promotores: G.R. de Snoo, B. Sinsin, Co-Promotor: H.H. de Iongh

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

To meet the rising demand for minerals driven by the global shift to clean energy technologies, ensuring responsible and resilient supply chains is critical. Minerals like cobalt, lithium, and nickel for batteries, neodymium and zinc for wind turbines, and indium for solar panels are essential.

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

The book ‘Bestrijdingsmiddelen en Milieu' gives a transparent overview of facts and figures concerning pesticide use in the Netherlands and the impact of pesticides on the environment.

The work presented in this thesis is based on ALMA surveys of protoplanetary disks in three star-forming regions: Lupus, OMC-2, and NGC 2024.

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)

Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).

Global Environmental Extensions Multi-Regional Input-Output (EE-MRIO) analysis is often used to analyze how changes in global and national demand for products lead to socioeconomic and environmental impacts at the national level.

Fundamental research in the ALgebra, Geometry And Number Theory

Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.

A modern ship design process is subject to a wide variety of constraints such as safety constraints, regulations, and physical constraints.

The haplolepideous mosses (Dicranidae) comprise about 4000 species distributed over a wide range of habitats, with great gametophytic and sporophytic morphological variation. Their monophyly is well supported by the results of several molecular phylogenetic studies, which shed light on their relationships…

Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.

Promotor: S.M. Verduyn Lunel, Co-promotor: O.W. van Gaans