The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

In this thesis I highlight the applications of Oxford Nanopore Technologies (ONT) sequencing. This technique is a relatively new approach in the sequencing field, where nanopores are embedded in a membrane, DNA molecules are pulled through nanopores and an electrical current serving as the sequencing…

In this thesis new methodologies are developed for the detection and systematic study of radio sources in the early universe. This allows us to gain a deeper understanding of the formation and evolution of galaxies, the activity of supermassive black holes, and the final phase transition of our universe:…

The 2023 Conference: Institutions for Conflict Resolution (COI) aims to identify just institutional approaches that seek (real) conflict prevention and conflict resolution in the legal context. It will be held in Utrecht on 28 and 29 September 2023. We welcome abstracts from all researchers around the…

De opleiding Life Science and Technology (LST) stond 9 september 2014 met een feestelijk gebakje stil bij haar 15 jarig bestaan. Het gaat bijzonder goed met de opleiding. Er zijn veel eerstejaars studenten en LST masterstudenten vinden of vóór hun diploma-uitreiking of er vlak na een goede baan.

Laboratory, observation and modeling work on the dissociation of polycyclic aromatic hydrocarbons in interstellar environments and the formation of new molecular species through the fragmentation process.

Op 29 June 2017 heeft Carl Mair zijn proefschrift “Taking Technological Infrastructure Seriously” verdedigd. De supervisors zijn prof.mr. A. Schmidt en prof.dr.mr. G.J. Zwenne.

In this course, you will explore the organs involved in our food digestion and discover the common causes of abdominal and pelvic pain. The latest graphics and animations will give you new insights and understandings of this part of the body.

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The project

Leidse AI-Week

Lezing, Workshop

What are the environmental trade-offs for SMEs considering moving from monoculture aquaculture practice towards IMTA? What are the environmental trade-offs comparing IMTA species with their conventional monoculture alternatives?

Als student van de master Criminologie en Veiligheidsbeleid ontwikkel je academische, theoretische en onderzoeksvaardigheden waarbij alle aspecten van veiligheidsbeleid aan bod komen.

De Leidse Universiteit heeft een lange en waardevolle traditie in de Papyrologie.

In 2011 en 2012 zijn verschillende projecten uitgevoerd gericht op de ondersteuning van de implementatie van de Kennisbasis bij de tweedegraads lerarenopleidingen Duits en Frans.

In dit artikel presenteren Andrea Bartolucci en Michele Magni een evidence-based onderzoek naar de spontane opname van slachtoffers en de verdeling van patiënten in de onmiddellijke nasleep van de Manchester Arena Bombing.

Promotie

Promotie

Promotie

Promotie

Het initiatief voor de organisatie Alternative Approaches and Global Concerns (APGC) is geboren uit een reeks conferenties over terrorisme, religie, geweld en ethiek aan weerszijden van de Atlantische Oceaan. Dr. Rico Sneller, Leids Instituut voor Godsdienstwetenschappen, is medeoprichter.

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

Promotor: Arjen Doelman, Co-promotor: Vivi Rottschäfer

In this dissertation several settings in the Online Learning framework are studied. The first chapter serves as an introduction to the relevant settings in Online Learning and in the subsequent chapters new results and insights are given for both full-information and bandit information settings.

Discover the Summer School Program Population Health Management by LUMC and learn about strategies to deal with current issues and developments in healthcare.

The origin and evolution of galaxies are closely tied to the cyclic feedback processes between stars and the interstellar medium (ISM).

One of the key quests in astronomy is to study the growth and evolution of galaxies across cosmic time. Radio observations provide a powerful means of studying the formation of stars and subsequent buildup of distant galaxies, in a way that is unbiased by the presence of dust.

In today's volatile market environments, companies must be able to continuously innovate. In this context, innovation does not only refer to the development of new products or business models but often also affects the entire organization, which has to transform its structures, processes, and ways of…

In this thesis,

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

Promotor: Prof.dr. S. Haring

This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.