5,546 zoekresultaten voor “leiden institute for bram and cognitive” in de Publieke website
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Shaping the pharmacokinetic landscape for renally cleared antibiotics in obesity
The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.
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Harnessing zebrafish xenograft models for ocular melanoma treatment discovery
The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…
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Spatiotemporal building stock modeling for residential decarbonization in the Netherlands
Decarbonizing the building stock is critical for realizing the climate-neutral target for the Netherlands.
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Discovery of BUB1 kinase inhibitors for the treatment of cancer
The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.
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Matchmaking for open innovation: perspectives on multi-sided markets
Promotores: Prof.dr. B.R. Katzy, Prof.dr. K. Sailer (Munich University)
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Real-time foresight: preparedness for dynamic innovation networks
Promotor: H.J. van den Herik, B.R. Katzy, Co-promotor: K. Sailer
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Aggravating matters: accounting for baryons in cosmological analyses
Three major cosmology-focused missions are planned for the next decade: the Euclid space telescope, the Vera C. Rubin Observatory in Chile, and the Nancy Grace Roman Space Telescope.
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Tailoring x-ray tomography techniques for cultural heritage research
Visualizing the internal structure is a crucial step in acquiring knowledge about the origin, state, and composition of cultural heritage artifacts. Among the most powerful techniques for exposing the interior of cultural heritage objects is computed tomography (CT), a technique that computationally…
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Silicon pore optics for high-energy optical systems
This thesis examines silicon pore optics (SPO), a technology that exploits silicon wafers from the semiconductor industry to create extremely high quality X-ray optics, by studying its manufacturing process, applications, and prospects.
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Class invariants for tame Galois algebras
Promotores: B. Erez, P. Stevenhagen, Co-Promotor: B. de Smit
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Biomimetic Copper Complexes for Energy Conversion Reactions
Hetterscheid
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Onderzoekers
In dit interdisciplinaire onderzoeksprogramma werken onderzoekers uit vijf verschillende disciplines met elkaar samen. Zij stellen zich hieronder (in het Engels) aan u voor.
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Shape Analysis for Phenotype Characterisation from High-throughput Imaging
We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.
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Call for papers interdisciplinair congres 'EU Criminal Justice Policy and Practice - Reflections and Prospects'
Dit interdisciplinair Engelstalig congres, dat wordt gehouden op 26 en 27 juni 2017, beoogt (strafrecht)juristen, criminologen, sociologen, politicologen en (rechts)filosofen bijeen te brengen voor een gezamenlijke reflectie op de ontwikkeling van een strafrechtelijk beleid in de Europese Unie.
- 'Only Connect': de romans van E.M. Forster
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Iron complexes as electrocatalysts for the water oxidation reaction
In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.
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A semisynthetic peptide-metalloporphyrin responsive matrix for artificial photosynthesis
This thesis is concerned with the constitution of chiral responsive matrix assemblies that may undergo light-driven conformational changes and self-select vibrations to develop vibronic states for driving semi-classical coherent transfer with nearly 100% yield in a lossless NCAP process.
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Understanding the value of social media metrics for research evaluation
The availability of indicators based on social media has opened the possibility to track the online interactions between social media users and scholarly entities.
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Applications of paramagnetic NMR spectroscopy for protein research
The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.
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Advanced in vitro models for studying drug induced toxicity
Promotor: B.van de Water, Co-promotor: L.S.Price
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Life Cycle Assessment of Nanomaterials and Risk Assessment.
What is the environmental impact, the human health impact and the life cycle and production costs of the lab, pilot and commercial diffusion of nanowires and nanowire-based photovoltaic technologies?
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Advances in computational methods for Quantum Field Theory calculations
In this work we describe three methods to improve the performance of Quantum Field Theory calculations.
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Imaging of alkyne-functionalized ruthenium complexes for photoactivated chemotherapy
In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.
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The astrochemical factory: A solid base for interstellar reactions
In this thesis chemical and physical processes in the ice mantles on interstellar dust grains are studied.
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Liposomes as delivery system for allergen-specific immunotherapy
In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.
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Laura Steenbergen
Faculteit der Sociale Wetenschappen
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educational interventions with computer programmes: the influence of genetic and neurobiological factors
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Onderwijs
Het LIBC is actief betrokken bij training & onderwijs op het gebied van hersenen en cognitie.
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Artistic Research in Music: Discipline and Resistance - Artists and Researchers at the Orpheus Institute
Publicatie boek 'Artistic Research in Music: Discipline and Resistance' markeert 20-jarig jubileum Orpheus Instituut.
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Evolution and development of flowers, fruits and inflorescences of Phalaenopsis and other orchid species
The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.
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2 Assistant Professors in Generative AI and Human-centered AI
Wiskunde en Natuurwetenschappen, Leiden Institute of Advanced Computer Science (LIACS)
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Leiden Academic Centre for Drug Research
Het ontwikkelen van nieuwe medicijnen is een complex proces waarbij veel partijen samenwerken. De onderzoekers van het LACDR zetten zich dagelijks in voor nieuwe, betere, efficiëntere en makkelijker produceerbare medicijnen. Het instituut werkt nauw samen met het LUMC, met bedrijven op het Leiden Bio-Science…
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Dr. Simon Willmetts ontvangt fellowship van het Netherlands Institute for Advanced Study
Dr. Simon Willmetts, verbonden aan het Institute of Security and Global Affairs (ISGA) van de Universiteit Leiden, heeft een fellowship ontvangen aan het Netherlands Institute for Advanced Study in the Humanities and Social Sciences (NIAS-KNAW) in Amsterdam.
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Peptide-based probes for protein N-Methyltransferases
The work described in this thesis focuses on the development of linear or cyclized peptide probes against protein N-methyltransferases to characterize their specific binding behavior, providing further binding details for inhibitory activity study.
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Imagining Justice for Syria: Water Always Finds Its Way
Op 29 april 2020 verdedigde Beth Van Schaack haar proefschrift 'Imagining Justice for Syria: Water Always Finds Its Way'. Het promotieonderzoek is begeleid door promotor prof.dr. C. Stahn.
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Exploring the mechanisms of metastatic onset for novel treatment strategies
This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.
- From basic research to therapy development for neuromuscular disorders
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Quantitative pharmacological modelling for optimizing treatment of sepsis
Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…
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Statistical modelling of time-varying covariates for survival data
This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.
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Predicting the future: Predictive control for astronomical adaptive optics
The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.
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Novel Immune Cell-Based Therapies for Atherosclerosis
Promotor: Prof.dr. J. Kuiper
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Hunting for the fastest stars in the Milky Way
The high velocity tail of the total velocity distribution of stars provides essential insight into fundamental properties of the Galaxy.
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The hunt for frozen organic molecules in space
Complex Organic Molecules (COMs) have been detected in objects across different stages of stellar evolution.
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Inverse problems for universal deformation rings of group representations
Promotor: Prof.dr. P. Stevenhagen
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Circular city & Industry park MATerials metabolism learning package and assessment tool
Some examples of research questions include: What framework of circular strategies should local practitioners use? How should practitioners organize their monitoring of the circular economy activities in the region of interest? What are the main products that have the most circular potential in the…
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Libya Since the 2011 Revolution: Troubles, Causes, and Future
Professor Dirk Vandewalle is een internationaal veelgevraagde en gerenommeerde Libië-expert. In deze lezing gaat hij in op twee essentiële vragen over de huidige situatie in Libië. Hoe komt het dat het Libische politieke systeem zo fragiel geworden is? En hoeveel hoop is er nog dat Libië als eenheid…
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Development of life cycle assessment for residue-based bioenergy
Wat zijn de belangrijkste thema's in het uitvoeren van systemen voor bio-energie ?
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OFAC, Famine, and the Sanctioning of Afghanistan: A Catastrophic Policy Success
Matthew Hoye pleit voor een regulerend analytisch perspectief om de sancties tegen Afghanistan te bekijken.
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Development of an Adverse Outcome Pathway (AOP) for metallic nanoparticles
What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?
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Analytical chemistry and biochemistry of glycosphingolipids: new developments and insights
Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…