Heart failure is a major health care problem with high mortality.

Mycoheterotrophy is a particular mode of life in which plants obtain carbohydrates from their associated fungal partners, instead of by using photosynthesis.

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.

Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

Balsaminaceae is a diverse plant family characterized by a huge floral morphological diversity.

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

Gibbs measures, as used in Statistical Mechanics, have a definition that is remarkably similar to the definition ofg-measures, used in dynamical systems.

Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

In this thesis we classify the pairs (p,G), where p is a prime number and G is a finite p-group possessing an intense automorphism, i.e. an automorphism that sends each subgroup of G to a G-conjugate, that is non-trivial and whose order is coprime to p.

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

Promotor: S.M. Verduyn Lunel, Co-promotor: S.C. Hille

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

Predictive maintenance (PdM) is a maintenance policy that uses the past, current, and prognosticated health condition of an asset to predict when timely maintenance should occur.

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.

Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.

In this thesis I highlight the applications of Oxford Nanopore Technologies (ONT) sequencing. This technique is a relatively new approach in the sequencing field, where nanopores are embedded in a membrane, DNA molecules are pulled through nanopores and an electrical current serving as the sequencing…

The parabolic Anderson model (PAM), which is the Cauchy problem for the heat equation with random potential. The PAM is a mathematical model that describes how mass (i.e. matter or energy) flows in a medium in the presence of a field of sources and sinks.

Acidobacteria is a widely distributed phylum but their functional roles in ecosystem processes are still largely elusive.

Metabolomics is a powerful tool that can provide a comprehensive insight into the complexity of human biology and the pathophysiology of diseases. By analyzing the metabolome, which refers to the complete set of small (endogenous) molecules (with a mass <1500 Da) present within a given biological system,…

The LUGO Press is a student publication forum, rooted in academia and journalistic practices and published by the Leiden University Green Office.

Kidney transplantation is a major advance of modern medicine. This course will give you state of the art updates about what used to be an experimental, risky, and very limited treatment option more than 50 years ago and is now routinely performed in many countries worldwide.

Wie complexe regio’s als het Midden-Oosten en Azië echt wil begrijpen, moet de cultuur, geschiedenis en lokale samenlevingen door en door kennen. Gedreven door een nieuwsgierigheid naar andere culturen, zorgt het Leiden University Institute for Area Studies (LIAS) voor begrip en de nodige duiding van…

Binnen de opleiding Japanstudies richt je je op verschillende vakgebieden. Je verdiept je in taalvaardigheid, geschiedenis, kunst, de samenleving en internationale betrekkingen van Japan.

Wil je meer weten over de opleiding Japanstudies en beleven hoe het is om in Leiden te studeren? Japanstudies biedt verschillende voorlichtingsactiviteiten om je te helpen bij je studiekeuze.

Op 17 augustus 1945, twee dagen na de Japanse capitulatie, verklaarde Indonesië zich onafhankelijk. Nederland erkende dit niet en trachtte met geweld zelf de regie te voeren over het onvermijdelijke proces van dekolonisatie. Dit leidde tot vier jaren van moeizame onderhandelingen en bittere oorlogvoering.…

Universe in a Box is erkend voor zijn educatieve waarde, door het Europese netwerk van Wetenschapseducatie (Scientix).

Public Administration is a major refereed journal publishing articles on public administration, public policy and public management.

Promotor: G.J.B. van Ommen

Athletes always strive for the top. How can data scientists assist them in improving their performance? During the seminar Data Science and Sports, the possibilities and challenges of collaboration between these two worlds were discussed.

What is the environmental impact of different waste collection systems across Europe? How can the collection be improved when considering collection, sorting, and treatment, as well as use options for secondary materials?

Promotores: B. Erez, P. Stevenhagen, Co-Promotor: B. de Smit

Promotor: Ronald Cramer, Co-promotor: Serge Fehr

It is a common technique in global optimization with expensive black-box functions to learn a surrogate-model of the response function from past evaluations and use it to decide on the location of future evaluations.

Indicators to measure progress in de-linking economic growth and environmental pressure.

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

Promotores: P. Stevenhagen, L. van Geemen (Università degli studi di Milano), Co-Supervisor: Ronald M. van Luijk

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

Promotores: H.W. Lenstra, K. Belabas (University of Bordeaux)

Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich

Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.