Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

Promotor: M. Danhof, Co-promotor: E.C.M. de Lange

Promotor: Prof.dr. M. de Jong

The different kinds of cultural perspectives on health and disease of the participants are related to their knowledge, beliefs, values and practices manifested in various forms of lifestyle in Indonesia. The cultural diversity of the population is also related to differences in health behaviour.

In today's volatile market environments, companies must be able to continuously innovate. In this context, innovation does not only refer to the development of new products or business models but often also affects the entire organization, which has to transform its structures, processes, and ways of…

Several single-stranded RNA viruses make use of Xrn1-resistant RNAs in their 3’ untranslated regions of their genome RNAs in order to increase their pathogenicity.

Promotor: M.K. Richardson, Co-Promotor: F. Witte

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

Promotores: Wim Jiskoot; Ferry Ossendorp

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

International trade has played a major role in defining the modern global economy. Trade, however, entangles the environmental pressures of economic sectors, giving the illusion of environmental improvements, while the opposite may be occurring.

The electrochemical oxygen reduction reaction (ORR) is an essential half-reaction for the utilization of hydrogen as a sustainable fuel, via the conversion of hydrogen to electrons and protons facilitated by the ORR. In the most common fuel cells, the ORR is requires high loadings of non-abundant platinum…

In my research, we developed a method to distinguish knots. A knot is a mathematical depiction of the everyday knot that occurs in ropes and cords.

Promotor: S.M. Verduyn Lunel

Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Climate change is one of the largest challenges faced by humanity. To combat this research into alternatives to fossil fuels is ongoing. Dihydrogen is considered a good alternative fuel, since its burning only forms water.

This PhD thesis concerns the topic of arithmetic geometry. We address three different questions and each of the questions in some way is about counting how big some set is or can be.

Promotors: Prof.dr. P.J. Punt, Prof.dr. C.A.M.J.J. van den Hondel

Promotores: Prof.dr. G.A. van der Marel, M. van Heel

Promotores: T.H.W. Bäck, Y. Tan, Co-promotor: M.T.M. Emmerich

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

Promotor: Koen Kuijken Co-promotor: Henk Hoekstra

AI Labs zijn samenwerkingen van de Universiteit Leiden met externe partner zoals bedrijven, overheidsinstellingen en andere universiteit op het gebied van kunstmatige intelligentie. De Faculteit voor Wis-en Natuurkunde is uniek gesitueerd op het grootste Bioscience Park van Nederlands, en ligt direct…

Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)

Galaxies are environments where gas coalesces, cools, and is converted into stars. However, it remains unclear the exact mechanisms through which galaxies acquire, redistribute and lose their gas.

Promotor: J. Zaanen

Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…

Promotores: J. Jonkers, K.E. de Visser

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

Continuous optimization is never easy: the exact solution is always a luxury demand and the theory of it is not always analytical and elegant.

Het doel van het RAISE Onderzoek is om te onderzoeken hoe veerkrachtige mensen omgaan met stress. We kijken specifiek naar hoe belangrijke biologische systemen, zoals de HPA-as en het immuunsysteem, samenwerken met de hersenen en de sociale omgeving om veerkrachtig functioneren na moeilijkheden in de…

Promotores: G.W. Canters, T.J. Aartsma

Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…

Promotor: Prof.dr. C.W.J. Beenakker

With the help of quantum mechanics, digital quantum hardware may be able to tackle some of the problems that are too difficult for ordinary computers. But despite these expectations and the ongoing effort of the research community, reliable quantum computers are not yet realized in a lab setting.

Een online platform met leerzame en sociale uitdagingen ter voorbereiding op de veranderende arbeidsmarkt. Met dat idee won het team Piece of Skill op 27 augustus de Deans' Challenge. In deze wedstrijd bedenken studenten oplossingen voor mondiale zorgen, geselecteerd door decanen van de Universiteit…

De Afdeling Jeugdrecht van de Universiteit Leiden en Defence for Children nodigen u van harte uit voor de uitreiking van de negende Jaap Doek Kinderrechtenscriptieprijs. Deze vindt online plaats, op dinsdag 7 december vanaf 15.30 uur (in het Engels).

Alle keuzevakken op het gebied van de Intellectuele Eigendom in de Master Rechtsgeleerdheid in Leiden (Auteursrecht, Merkenrecht en Octrooirecht) worden in het najaar van 2020 volledig online gegeven, met extra masterclasses en praktijktutoren.

Niet alleen voor het onderwijs maar ook voor de studentenwerving, zijn de afgelopen weken de laatste Corona maatregelen komen te vervallen. Waar de wervingsactiviteiten in het najaar nog gebukt gingen onder allerlei beperkingen in groepsgrootte en looproutes, verwelkomde de Campus Den Haag de afgelopen…

Een online zelfhulpprogramma is samen met telefonische coaching effectief in het verminderen van depressieve klachten bij mensen met hiv. Dat blijkt uit onderzoek van Sanne van Luenen (Klinische psychologie). Op kosten van het Aidsfonds helpt Van Luenen dit programma te realiseren. Promotie op 26 ju…

Sociale media geven mensen een stem, maar wakkeren ook online haat aan, vooral tegen minderheden. Promovenda Eva Nave: ‘Hoewel end-to-end-versleuteling mensenrechtenactivisten beschermt, maakt het ook criminele activiteiten mogelijk. Zo ontstaat een soort Darkweb 2.0.’