This thesis describes the implementation and on-sky demonstration of high-resolution integral-field spectroscopy for extreme adaptive optics systems that are used to find and characterize exoplanets.

Promotor: Prof.dr. W.J.G.M. Peijnenburg

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

Subproject of the ERC project 'Challenging the Liberal World Order from Within: The Invisible History of the United Nations and the Global South'.

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

Promotor: Prof.dr. S.F. Portegies Zwart

Several single-stranded RNA viruses make use of Xrn1-resistant RNAs in their 3’ untranslated regions of their genome RNAs in order to increase their pathogenicity.

More than 5,000 exoplanets have been found over the past couple of decades. These exoplanets show a tremendous diversity, ranging from scorching hot Jupiters, common super-Earths, to widely separated super-Jupiters on the planet/brown dwarf boundary.

In this thesis we classify the pairs (p,G), where p is a prime number and G is a finite p-group possessing an intense automorphism, i.e. an automorphism that sends each subgroup of G to a G-conjugate, that is non-trivial and whose order is coprime to p.

Promotors: Prof.dr. G.R. de Snoo, Prof.dr. H. Leirs (Univ. Antwerpen)

Promotores: Prof.dr. M. Franx, Prof.dr. P.G. van Dokkum (Yale University)

The invention of neural networks marks a critical milestone in the pursuit of true artificial intelligence. Despite their impressive performance on various tasks, these networks face limitations in learning efficiently as they are often trained from scratch.

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

Promotor: F. Arbab

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

Overall dispersion in LCA as result of inherent uncertainties, spread and unrepresentativeness.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. M. van der Zee

Langetermijnontwikkelingen, zoals het verouderen van de bevolking, de toename in de gemiddelde levensverwachting en de gevolgen van de recente financiële crisis, hebben bijgedragen aan de discussie rondom de houdbaarheid van het pensioenstelsel.

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

This thesis is concerned with the constitution of chiral responsive matrix assemblies that may undergo light-driven conformational changes and self-select vibrations to develop vibronic states for driving semi-classical coherent transfer with nearly 100% yield in a lossless NCAP process.

PNEC-pro is a user-friendly screening tool for professionals dealing with the assessment of surface water quality. The tool calculates local, watertype specific no-effect concentrations (PNEC) of copper, lead, nickel and zinc based on biotic ligand models (BLMs).

Promotor: G.R. de Snoo, Co-promotor: C.J.M. Muster

Promotores: G.W. Canters, T.J. Aartsma

Combinatorial games are games for two competing players, moving in a turn-by-turn fashion, in which there is no chance nor hidden information⁠. Chess, checkers and the simpler tic tac toe are well-known examples of this class of games, as well as game of go⁠.

How presence, abundance and enzymatic activities of AM and EM fungi differently affect soil carbon sequestration processes?

Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.

Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.

Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst

This thesis describes the use of a combined approach of computational and experimental techniques to gain novel insights to understand the glycosylation reaction and its reactive intermediates.

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

The experiences of ethnic ‘Other’ females have – until recently – been widely overlooked in the study of sport. There continues to be a need to produce critical scholarship about ethnic 'Other' girls and women in sport and physical culture, in order to represent their complex, multifarious and dynamic…

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

De Honours Academy is gevestigd in de Oude Sterrewacht aan de rand van het centrum van Leiden.

This thesis describes the role of pollution, specifically neonicotinoid insecticides, as an actor of the ongoing biodiversity decline.

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

The focus of this thesis is on the technical methods which help promote the movement towards Trustworthy AI, specifically within the Inspectorate of the Netherlands.

Stochastic resetting is simple enough to be approached analytically, yet modifies stochastic processes in a non-trivial way.

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Software development is a complex process. It is important that software products become stable and maintainable assets.

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Artful Mathematics: The Heritage of M. C. Escher

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Our recent excavations have focused on the more recent New Kingdom/Late Period (ca. 1500-332 BCE) material.

Promotor: H.J.A. Röttgering, Co-promotor: M. Haverkorn

Promotor: Prof.dr. J. Kuiper

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen