In this thesis we present several methods to automate tomographic reconstruction algorithms and several novel tomographic reconstruction algorithms with the focus on being easily applicable and efficient to use.

This course explores international arbitration as one of the most common methods of international dispute settlement. You will gain an in-depth understanding of international arbitration through the analysis of its role as a mechanism of dispute settlement, its institutions, the fields of law it is…

This thesis develops statistical methods for the analysis of high dimensional data: high dimensional networks reconstruction (Chapters 1-4), incorporation of prior information in networks reconstruction (Chapters 2-4), incorporation of prior knowledge in genetic association studies (Chapter 3).

Promotie

Promotie

'Ik ben ervan overtuigd dat als er momenteel nog geen publieke omroep zou bestaan en we zouden bedenken dat het goed zou zijn om publiek geld (oftewel belastinggeld) te steken in journalistiek, het in niemand zou opkomen om dat geld te spenderen aan algemeen nieuws op radio, televisie en internet. Dat…

Science is typically a patchwork of research contributions without much coordination. Especially in clinical trials, the follow-up studies that we do fail to be the most promising.

Supervisor: S.F. Portegies Zwart Co-Supervisor: A.G.A. Brown

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

Promotor: Prof.dr. E. Smets, M. Stech

The role of material production as a driver of environmental impacts is increasing, which calls for a better understanding of global material flows. This thesis explores the role of in-use stocks of products, buildings and infrastructure as a key driver of global material demand and discusses the implications…

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

Promotor: Prof.dr. J.P. Abrahams, Co-Promotor: N.S. Pannu

The goal of the project is the development of stream mining techniques for complex patterns such as graphs. We will try to extend the existing state-of-the-art techniques into two, orthogonal directions: on the one hand, the mining of more complex patterns in streams, such as sequential patterns and…

The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.

Leiden University and the Ministry of Infrastructure and Water Management are involved in a collaboration in the form of a research project titled 'Data-Driven Risk Assessment in Infrastructure Networks'

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

Promotor: P.D. Grünwald

Fungal food spoilage often starts with a contamination with spores. Experimental data strongly indicate the existence of subpopulations of spores with different levels of resistance to preservation methods.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

Organic molecules in interstellar space are important as they influence the structure of galaxies and star formations. Studying catalytic processes in space allows us to understand how molecular species are formed and chemically evolved in the interstellar medium and solar system objects.

Promotor: F.S. de Boer, Co-promotor: M.M. Bonsangue

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.

Possible improvements for the assessment of abiotic depletion in LCA.

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

De opmars van het gebruik van laptops en tablets in het klaslokaal is in volle gang. Maar wat zijn de gevolgen van leren met een scherm? NEMO Kennislink sprak met Adriaan van der Weel, bijzonder hoogleraar in de moderne geschiedenis van het boek.

Wij verzorgen onderwijs voor de bachelor Rechtsgeleerdheid, de Advanced Master Law and Digital Technologies, de master Jeugdrecht, de Advanced Master International Children’s Rights, de Honours Academy, de Pre-Classes en het Post Academisch onderwijs aan de Universiteit Leiden.

What are the flows of C&DW (e.g. bricks, concrete, gypsum and wood) in the case study countries ? How to define the specification for each material to be quantified? What indicators should be used to identify the pattern of each C&DW management system? How to interpret the MFA results in relation…

The basic program comprises a total of twelve courses organized by the Research School, that have been purpose-developed for training and support of PhD students and Research MA students who specialize in Medieval Studies (history, art history, and literary history, in particular).

Nieuwe digitale methoden en een explosie van data hebben archeologisch onderzoek voorgoed veranderd. Karsten Lambers, Universitair Hoofddocent Archeologische Informatica, vertelt erover.

De meta-curriculaire programma's van het LMW zijn gericht op duurzame persoonlijke ontwikkeling en begeleiding.

Promotor: A.W. van der Vaart

The work described in this thesis focuses on the development of linear or cyclized peptide probes against protein N-methyltransferases to characterize their specific binding behavior, providing further binding details for inhibitory activity study.

Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.