A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

This thesis aims to enhance our understanding of galaxies by testing theoretical models of galaxy formation against observations, particularly in the cases of extreme systems which have been found to have an excess of baryonic mass in their central regions, in the form of either supermassive black holes…

Indicators to measure progress in de-linking economic growth and environmental pressure.

Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).

Promotor: Prof.dr. M. Schilthuizen

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

A substance flow analysis, covering about 99 % of the flows of chlorinated substances in the Netherlands.

In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.

Promotores: H.W. Lenstra, K. Belabas (University of Bordeaux)

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

Leiden University and the Ministry of Infrastructure and Water Management are involved in a collaboration in the form of a research project titled 'Data-Driven Risk Assessment in Infrastructure Networks'

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

Promotor: F.J. van Lunteren, E. Jorin

The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…

Natural resources often stretch across borders that separate modern nation states. This can create conflict and limit opportunities for regulated consumption of their goods and services, but also provide opportunities for joint multinational efforts that exceed single country capabilities.

Promotores: J. Kok, M. Chaudron (Chalmers University)

With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…

Which traits and/or trade-offs determine benefits of being deciduous or evergreen?

To gain more insight into the evolutionary development of orchid flowers and fruits, the orchid species Erycina pusilla was studied. The evolutionary origin of the median petaloid sepal, the callus on the labellum, and the stelidia was studied.

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Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)

“Een partnerschap gebaseerd op water”, zo vatte Gerhard van den Top de relatie tussen Nederland en de Filipijnen samen in de 4e Louwes lezing. Hij benadrukte de cruciale rol van internationale en interculturele samenwerking in het managen van de complexe uitdagingen veroorzaakt door klimaatverandering.…

Integratie van MOOC in campus

D2.2 comprises the in-depth legal analysis of the initial heuristic model, focused on addressing, in more detail, the main legal concerns for data reusers in the European data economy. This detailed analysis of the legal propositions presented in D2.1 is supplemented by an analysis of the technological,…

The class-imbalance problem is a challenging classification task and is frequently encountered in real-world applications. Various techniques have been developed to improve the imbalanced classification performance theoretically and practically.

This thesis is based on five papers on several topics.

An overview is given of the flows of chlorine and chlorinated hydrocarbons through the Europian Union.

Het Nederlands-Vlaams Instituut in Cairo (NVIC) is in 1971 opgericht. Negen universiteiten in Nederland en Vlaanderen participeren in het NVIC met als doel het stimuleren en internationaliseren van hun onderwijs- en onderzoeksactiviteiten in het Midden-Oosten. De beheervoerende instelling is de Universiteit…

EXIOBASE is a global, detailed Multi-regional Environmentally Extended Supply and Use / Input Output (MR EE SUT/IOT) database. It was developed by harmonizing and detailing SUT for a large number of countries, estimating emissions and resource extractions by industry, linking the country EE SUT via…

In 2013-2014, CML published over 100 papers, contributed to various international sustainability debates, renovated our building and educated thousands of students from all over the world through our MOOC. These accomplishments and many more are highlighted in this booklet, CML wish you a pleasant…

Multicellular giant algae Chara species have been widely used in physiological studies for decades.

Promotores: C.A.M.J.J. van den Hondel, V. Meyer, Co-promotor: A.F.J. Ram

Tijdens deze studie volg je colleges, oefen je met wiskundige afleidingen en voer je experimenten uit. Hierdoor bouw je een stevige basis in verschillende vakgebieden, zoals natuurkunde en wiskunde.

Als student van de master Criminologie en Veiligheidsbeleid ontwikkel je academische, theoretische en onderzoeksvaardigheden waarbij alle aspecten van veiligheidsbeleid aan bod komen.

Handen uit de mouwen voor duurzaamheid! Dat doen medewerkers en studenten op verschillende manieren, thuis en op de universiteit.

The Grotius Centre, in collaboration with Duke Law School, will be hosting the Duke-Leiden Institute in Global and Transnational Law from 14 June to 15 July 2020 in The Hague, the International City of Peace and Justice.

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf

The research group Science Communication and Society aims to understand how science communication works to improve the interaction between science and society. Central themes are ‘Bridging the gap between experts and the general public’ and ‘Evaluating Science Communication’.

In de landelijke Onderzoekschool Mediëvistiek werken onderzoekers op het gebied van de Middeleeuwen van zes Nederlandse universiteiten samen. De school verzorgt (in samenwerking met de lokale graduate schools van de universiteiten) de opleiding tot mediëvistisch onderzoeker en biedt ook opleidingsactiviteiten…

Uw persoonlijke en professionele ontwikkeling stopt niet bij het behalen van uw diploma. De faculteit en universiteit bieden u tal van mogelijkheden om na uw studententijd voor een gereduceerd tarief trainingen en workshops te kunnen volgen. Zo kunt u zich blijven ontwikkelen.

How can prospective LCA be streamlined in a way that its practical application in research and technology development increases?

Goede studievoorlichting en kennismaking met wetenschap: de Universiteit Leiden helpt scholen, docenten en decanen graag hiermee.

Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.

Een bul of diploma is een waardevol document dat slechts één keer wordt verstrekt door de universiteit. Indien een persoon zijn bul kwijtraakt, kunnen oud-studenten bij DUO in het diplomaregister een diploma-uittreksel downloaden.

Welkom, en leuk dat je geïnteresseerd bent in Designing Your Life-onderwijs! Of je nu student bent of onderwijs ontwikkelt, deze website heeft alles wat je nodig hebt om met DYL aan de slag te gaan.

De masteropleiding Health, Ageing and Society leidt haar studenten op tot academische professionals op het gebied van gezondheid, ouderen en samenleving. Studenten voelen zich na afronding van de opleiding betrokken bij de maatschappij en zijn in staat om een bijdrage te leveren aan oplossingen voor…