At the moment, over 350.000 chemicals are registered worldwide for production and use. Their application, however, may harm human health and the environment.

The availability of indicators based on social media has opened the possibility to track the online interactions between social media users and scholarly entities.

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.

The work presented in this thesis is based on ALMA surveys of protoplanetary disks in three star-forming regions: Lupus, OMC-2, and NGC 2024.

Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.

Materials balances have been used in the recent past for the analysis of substance oriented environmental problems and the formulation of measures for environmental policy. In this study an integrated tool, based on the materials balance principle, has been developed for the analysis of both environmental…

Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

This thesis considers multi-prover commitment schemes whose security is based on restrictions on the communication between the provers.

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

LCA has become an important method to study environmental impacts of human activities. Still, there are several methodological issues in LCA that can adversely affect the results reliability.

It is an established fact that the Standard Model has to be extended to explain the so-called Beyond the Standard Model (BSM) phenomena: dark matter, matter-antimatter asymmetry of the Universe and neutrino flavour oscillations.

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Business Process Model and Notation (BPMN) has become the standard for business processes diagrams.

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

This thesis is comprised of three chapters covering the theme of studying semistable varieties by looking at their dual combinatorial objects.

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

Possible improvements for the assessment of abiotic depletion in LCA.

Promotor: E.F. Smets, Co-promotor: T.R. van Andel

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

In the thesis the dynamics of strategies is studied from two perspectives.In the first part of the thesis strategies are considered to be opinions present in a community.

Development of GHG calculator for bio-electricity and heat.

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

De Griekse papyrologie is de wetenschap die zich bezighoudt met het ontcijferen en bestuderen van alle teksten die in de Griekse taal op papyrus geschreven staan. Papyrus was het schrijfmateriaal van de oudheid en werd vervaardigd uit op elkaar gekleefde reepjes van de papyrusplant.

This thesis has shed light on some of the ways in which the local electrolyte composition can differ from the bulk and how these changes in the local reaction environment can determine the activity and/or selectivity of two important electrocatalytic reactions, namely, electrochemical CO2 reduction…

M.T.M. Koper, Co-promotor: D.G.H. Hetterscheid

Tuberculosis (TB) is associated with 1.5 million deaths annually. There is a need exists to optimize both current as well as novel antibiotic combination treatment strategies to improve the effectiveness and safety of treatments against TB.

Since its beginnings, Leiden University has been home to scholars with a broad and diverse expertise in the histories, languages, literatures and material cultures relevant to the study of Jews and Judaism from antiquity to modern times.

Description of Atlas of the surfacewater concentrations of pesticides in the Netherlands, a pilotstudy.

Students Practicing Citizen Journalism

Do sustainability values play a role in motivating people to act for biodiversity in successful projects and in successful leadership action? And how could these values be incorporated in current economic valuation methods?

This project uses archaeological, literary and epigraphic evidence to investigate urban development in Roman-period North Africa, compiling this in a GIS-linked database in order to analyse the development of urban settlement spatially over time.

What is the population size/structure and distribution of tiger and leopard inside the Bardia National Park (BNP) compared with the population outside? What is the movement and home range and conflict pattern in time and space of tigers and leopards inside the BNP compared with outside? What constitutes…

Do e-waste workers display enhanced effects of adverse health effects due to informal e-waste processing in Nigeria? Is there a difference between the health outcomes of the exposed and the control groups? Are there difference in health effects within and between job groups (collectors, dismantlers,…

A critical look at the impact assessment modelling of metals in Life Cycle Impact Assessment and improvement options.

Hoe ziet je leven er uit als je wetenschapper wordt? Het Faces of Science project van de Konklijke Nederlandse Akademie van Wetenschappen breidt uit. Twaalf nieuwe promovendi gaan verslag doen van hun dagelijks bestaan in de wetenschap, in filmpjes en blogs. Één van deze promovendi is Lennart Kruijer…

Lezing

Alumni-activiteit

Wiskunde en Natuurwetenschappen, Mathematisch Instituut (MI)

Wat zijn de belangrijkste thema's in het uitvoeren van systemen voor bio-energie ?

Wiskunde en Natuurwetenschappen, Mathematisch Instituut (MI)

How did colonial law work to turn people into property? This project argues that colonial ideas about households and domestic authority were critical to legal processes of enslavement in the early modern Dutch empire. Using colonial court records from Dutch Brazil, Suriname, and the Moluccas, the project…

Kunst en vrije tijd, Kunst en vrije tijd