Geesteswetenschappen, Institute for Area Studies

Spinozapremiewinnaars Naomi Ellemers, Ineke Sluiter, Marijn Franx (Leiden) en Piet Gros (Utrecht) maakten op maandag 27 september 2010 bekend wat ze met hun premie van € 2,5 miljoen gaan doen. Dat gebeurde in Den Haag bij de officiële uitreiking door demissionair staatssecretaris van OCW, Marja van…

Leidse astronomen en hun team vonden half januari verschillende interessante moleculen in de donkerste en koudste dieptes van een stervormende gaswolk. Ze kregen hierbij hulp van de nieuwe James Webb telescoop. Ze vertellen erover bij Meer Wetenschap Vandaag op BNR.

This thesis describes the development and validation of new high-contrast imaging techniques, with the ultimate goal of enabling the next generation of instruments for ELT-class telescopes to directly image Earth-like extra-solar planets orbiting around nearby stars.

I have studied the hot, diffuse gas around and between galaxies. Specifically, I have used the EAGLE numerical simulations of galaxy formation to predict the properties of this gas, and I have used those properties to predict specific observables: soft X-ray absorption and emission lines.

Lezing

Organic molecules in interstellar space are important as they influence the structure of galaxies and star formations. Studying catalytic processes in space allows us to understand how molecular species are formed and chemically evolved in the interstellar medium and solar system objects.

We have examined sequences from the ligand-binding domain of the nicotinic acetyl choline receptor (nAChR) in 148 vertebrate species. We are in interested in this receptor because the α-neurotoxins of many venomous snakes binds to this receptor in its location at the neuromuscular junction in all ve…

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

Investigating epistemic and ethical practices in medical experimentation on humans in the colonial period in Southeast Asia.

Producing green energy has become the main goal in our society in the search of reducing or eliminating the carbon emission from fossil fuels.

Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

Does roadside management in the mid-west USA increase invertebrate diversity similar to practices in Europe?

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

Promotor: E.F. Smets, Co-promotor: J. Geml

In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.

Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.

This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…

Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.

Promotors: Prof.dr. T.H.W. Bäck, Prof.dr. B. Sendhoff (Technische Universität Darmstadt)

Promotor: Prof.dr. G.R. de Snoo

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

This work describes several studies into the electroreduction of carbon dioxide (CO2RR), both regarding mechanistical aspects and catalyst stability considerations. Mechanistic insights into carbon-carbon bond formation on a silver catalyst are described in Ch 2, were we find an acetaldehyde-like surface…

Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte

As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

In this thesis unconventional tools based on fluidic interfaces were developed to study the surface and interfacial chemistry of graphene, to characterize the intrinsic properties of graphene, to disentangle the effects of substrate and of the environmental factors, and to improve handling protocols…

Promotor: Prof.dr. E.F. Smets, Co-Promotor: L.W. Chatrou

Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

Diacylglycerol lipases (DAGLα and DAGLβ) are responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain and peripheral tissues. Selective DAGLβ inhibitors have been proposed as a potential treatment for inflammatory diseases with reduced potential for central…

Climate change is one of the largest challenges faced by humanity. To combat this research into alternatives to fossil fuels is ongoing. Dihydrogen is considered a good alternative fuel, since its burning only forms water.

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.

Ambtenarensystemen zijn wereldwijd krijgen wereldwijd veel kritiek. Dit artikel presenteert een onderzoek naar bewijsmateriaal over over overheidsprestaties en merictocratie.

Op de Oude Sterrewacht bieden we een aantal manieren voor scholen om op bezoek te komen. Naast de rondleidingen die wij organiseren zijn er speciaal voor scholen ook workshops te doen.

Promotor: S.M. Verduyn Lunel

Astronomen hebben met de James Webb Space Telescope mogelijk atmosferische gassen ontdekt rond 55 Cancri e, een hete rotsachtige exoplaneet die 41 lichtjaar van de aarde is verwijderd. Dit is het beste bewijs tot nu toe voor het bestaan van een atmosfeer van een rotsachtige planeet buiten ons zonnestelsel.…

Een sterrenstelsel kan groeien door gas uit zijn directe omgeving naar binnen te trekken. Maar astronomen weten nog niet precies hoe dit gebeurt. Sterrenkundige Joop Schaye gaat met een Europese onderzoekssubsidie van 1,5 miljoen euro op zoek naar antwoorden.

Nationaal parochialisme is de neiging om meer samen te werken met leden van de ingroup dan met leden van de outgroup. Angelo Romano, Matthias Sutter, James Liu, Toshio Yamagishi en Daniel Balliet bestudeerden nationaal parochialisme in verschillende landen en concludeerden in hun publicatie in Nature…

Promotie

Donkere materie vormt ongeveer tachtig procent van de totale massa in het heelal. Toch weten we nog steeds niet precies waarvan het gemaakt is. Astronoom Pavel Mancera Piña gaat op zoek naar antwoorden. Met een Veni-subsidie van NWO en de meest geavanceerde telescopen, waaronder de James Webb Space…