This project uses archaeological, literary and epigraphic evidence to investigate urban development in Roman-period North Africa, compiling this in a GIS-linked database in order to analyse the development of urban settlement spatially over time.

A common method to solve expensive function evaluation problem is using Bayesian Global Optimization, instead of Evolutionary Algorithms.

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

Where does the urge to collect come from? What are the explicit or underlying reasons for gathering large amount of objects?

Promotor: Prof.dr. E. F. van Dishoeck

Netherlands Statistics (CBS), Leiden University and the University of Amsterdam have started a collaboration in the form of a research project titled 'Enriching official economic statistics using data-driven modelling techniques'.

The external tissues of plants and animals are colonized by microbial communities termed microbiota. When organisms are exposed to environmental pollutants, these substances will therefore encounter microbiota at the exposure interface.

Promotor: E.F. Smets Co-promotor: J. Geml

Promotores: J.C. van Houwelingen, S.A. van de Geer

Promotor: P.D. Grünwald

Promotor: K.J. Batenburg

Bacteria are highly complex and diverse organisms that have adapted to survive in ecological niches ranging from the most extreme to the most heterogeneous environments.

Plant diversity is essential for us and our planet as it sustains the stability of our ecosystems, provides vital materials and food to us and supports many ecosystem services.

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

The theoretical explanation of cosmic acceleration is nowadays one of the biggest puzzles in cosmology.

In this work, we attempt to answer the question:

Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…

This thesis describes the role of pollution, specifically neonicotinoid insecticides, as an actor of the ongoing biodiversity decline.

Humans and songbirds learn their vocalizations early in life by exposure to the vocalizations of adult conspecifics. Often, better learning outcomes are achieved with live, social, tutors than with audio-only exposure to vocalizations.

Understanding the formation and evolution of planetary systems is one of the most fundamental challenges in astronomy. To directly image and study young exoplanets and the circumstellar disks they form from, dedicated high-contrast imaging instruments are built.

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

This thesis is about augmented reality (AR). AR is commonly considered a technology that integrates virtual images into a user’s view of the real world.

Promotor: Prof.dr. J.N. Kok, Co-promotor: A.J. Knobbe

We present an extensive study of methods for exactly solving stochastic constraint (optimisation) problems (SCPs) in network analysis. These problems are prevalent in science, governance and industry.

Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.

Balsaminaceae is a diverse plant family characterized by a huge floral morphological diversity.

In this Yearbook you will find some fascinating examples of what was done in 2021, not only by ourselves, but also by our international colleagues.

Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.

Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

Promotores: Prof.dr. G.A. van der Marel, M. van Heel

Promotores: W. Th. F. den Hollander, M.O. Heydenreich

Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.

Promotores: Prof.dr. A.G.G.M. Tielens, Prof.dr. L. Kaper (UvA)

Promotor: K.J. Batenburg, Co-promotor: A.W. van der Vaart, B. de Smit

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

Synthetic microswimmers take an important place within the interdisciplinary field of active soft matter.

In this PhD-thesis several new and existing data science application are described that are particularly focused on applications for tax administrations.

Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Co-promotor: H.H. de Iongh

Thermodynamics is one of the founding scientific pillars that has helped us better understand heat engines, biology, ecosystems, and even black holes. While it fundamentally describes large systems by examining the bulk behavior of their constituents, it is anchored in the statistical equivalence of…

The development of new environmentally sound technologies is seen as a key route towards achieving sustainability.

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

The invention of neural networks marks a critical milestone in the pursuit of true artificial intelligence. Despite their impressive performance on various tasks, these networks face limitations in learning efficiently as they are often trained from scratch.

Het doel van het RAISE Onderzoek is om te onderzoeken hoe veerkrachtige mensen omgaan met stress. We kijken specifiek naar hoe belangrijke biologische systemen, zoals de HPA-as en het immuunsysteem, samenwerken met de hersenen en de sociale omgeving om veerkrachtig functioneren na moeilijkheden in de…

Promotor: Prof.dr. T. Schmidt

Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

Complex Organic Molecules (COMs) have been detected in objects across different stages of stellar evolution.