There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

Promotie

The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

In this work we describe three methods to improve the performance of Quantum Field Theory calculations.

This thesis examines silicon pore optics (SPO), a technology that exploits silicon wafers from the semiconductor industry to create extremely high quality X-ray optics, by studying its manufacturing process, applications, and prospects.

In this thesis we study quantum transport phenomena on the nanometer scale, in two classes of materials: topological insulators with induced superconductivity and graphene superlattices.

This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.

Het centrale doel van dit proefschrift is inzicht verschaffen in hoe de implementatie van een peer educator-interventie van invloed kan zijn op de houding van leerlingen tegenover LHBT-leeftijdgenoten en op de relatie tussen deze houdingen en reflectie over burgerschap.

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

The availability of indicators based on social media has opened the possibility to track the online interactions between social media users and scholarly entities.

The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.

The work described in this thesis focuses on the development of linear or cyclized peptide probes against protein N-methyltransferases to characterize their specific binding behavior, providing further binding details for inhibitory activity study.

Organic amendments applied to agricultural fields can partially offset our carbon emissions to the atmosphere and improve the resilience of agriculture to the effects of climate change. Driving these benefits, however, are complex and poorly understood interactions between organic amendment properties,…

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…

Promotor: Prof.dr. J.N. Kok, Co-Promotor: W.A. Kosters

Promotor: Prof.dr. P. Stevenhagen

Within the field of astronomy, understanding how galaxies grow and evolve from the Big Bang to the present day is a challenging and complex question.

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

Op dinsdag 24 maart is het boek 'The European Public Servant: A shared Administrative Identity?' verschenen.

Wat zijn de belangrijkste thema's in het uitvoeren van systemen voor bio-energie ?

What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?

Op 29 april 2020 verdedigde Beth Van Schaack haar proefschrift 'Imagining Justice for Syria: Water Always Finds Its Way'. Het promotieonderzoek is begeleid door promotor prof.dr. C. Stahn.

Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.

Promotor: Prof.dr. J. Kuiper

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

Hieratic Papyrology

Op donderdag 16 november 2017 is Thomas Leclerc gepromoveerd op zijn proefschrift ‘A Corrective Approach to Reduce Aircraft Greenhouse Gas Emissions. Contribution to the Study of Interactions between Legal Orders of International Law’. Zijn promotoren zijn prof.dr. P.M.J. Mendes De Leon en prof. L.…

Trigonostemon Blume is a plant genus in the family Euphorbiaceae comprising 59 species.

Het ontwikkelen van nieuwe medicijnen is een complex proces waarbij veel partijen samenwerken. De onderzoekers van het LACDR zetten zich dagelijks in voor nieuwe, betere, efficiëntere en makkelijker produceerbare medicijnen. Het instituut werkt nauw samen met het LUMC, met bedrijven op het Leiden Bio-Science…

Promotores: Prof.dr. F.P. Israel, Prof.dr. P.P. van der Werf

Make more fluid: In condensed matter systems, electrons can acquire unusual properties from their interaction with the atomic lattice.

Promotie

The aim is to develop methods to assess environmental and occupational exposure to (individual) pesticides, to be applied in epidemiological studies investigating pesticide exposure and human health. Furthermore, we aim to investigate the potential association between exposure to pesticides and Parkinson’s…

Promotor: F.P. Israel, Co-Promoter: R. Meijerink

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

Op 17 december 2018 verdedigde Dejian Kong zijn proefschrift 'Civil Liability for Damage caused by Global Navigation Satellite System'. Het promotieonderzoek is begeleid door promotor prof. dr. P.M.J. Mendes de Leon.

Human civilization consumes a huge amount of fossil fuels, which has resulted in an atmospheric CO2 level which has not been higher in over 800 millennia.

The thesis describes terrestrial field trials aimed to detect side-effects of pesticides within the framework of pesticide registration procedures. Field trials were developed using vascular plants Brassica napus and Poa annua, caterpillars Pieris brassicae and effects on decomposition were studied…

Het doel van dit proefschrift is om eerst te onderzoeken welke vormen van samenwerkend leren bij de verschillende conservatoria in de praktijk worden gebracht, om vervolgens te kijken naar hoe samenwerkend leren kan worden geïmplementeerd.

Het BENEFIT-programma is een publiek-privaat ecosysteem in een nationaal consortium, met als doel patiënten met cardiovasculaire aandoeningen langdurig in hun eigen thuissituatie te ondersteunen bij een gezonde leefstijl.

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda