Quantum computers are a proposed fundamentally new type of computer. They aim to perform some computations much faster than previously possible by exploiting phenomena at the quantum scale, called superposition and entanglement.

Hoewel veel beroepsbeoefenaren in de gezondheidszorg aangeven vaak gebruik te maken van placebo-effecten en de mechanismen ervan, is er weinig formele training over hoe om te gaan met placebo- en nocebo-effecten in de klinische praktijk. Dit project wil deze kloof tussen wetenschappelijke kennis over…

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

There is accumulating evidence for an increase in severe global drought events. In particular, Europe experienced several severe droughts in 2003, 2015, and 2018 (unprecedented in the past 2,110 years). Such droughts have caused serious and far-reaching impacts on terrestrial ecosystems.

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

Over the last decades, aviation safety has improved strongly. As a downside, airline pilots do not have as many opportunities to develop through experience the competencies that they need in critical situations.

Promotor: J. A. Bouwstra

Het College van Bestuur van de Universiteit Leiden en het Faculteitsbestuur van de Faculteit der Wiskunde en Natuurwetenschappen nodigen u graag uit voor de officiële start van de bouw van de eerste fase van de nieuwe Bèta Campus.

The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

Promotor: B. van de Water

Promotor: S.M. Verduyn Lunel, Co-Promotor: O.W. van Gaans

Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri

The outbreaks of AIDS and COVID-19 showed clearly how infectious viruses can influence people’s lives. Investigating the changes in the host metabolism may provide a paradigm shift to consider immune-metabolic interactions as therapeutic targets.

Detecting planets during their formation stages is crucial for understanding the history and diversity of fully developed planetary systems like our own. However, observing young planets directly is challenging because they are often deeply embedded within their host protoplanetary discs, rich in gas…

De wereld is vol oorlog, en geen oorlog is zonder doden. Wat gebeurt er met de lichamen van dodelijke slachtoffers van oorlogsgeweld? De winnaar van de facultaire Jongbloed scriptieprijs 2015 is Welmoet Wels (Internationaal Publiek Recht). Haar scriptie Dead body management in armed conflict: paradoxes…

Vinasse is a major by-product generated by the sugarcane biofuel industry. It is a source of microbes, nutrients and organic matter and often it is recycled as fertilizer.

The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

Planets are formed in disks of gas and dust around young stars.

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Human vocal communication and music perception represent advanced cognitive skills, seemingly innate and universal. These faculties encompass a range of perceptual and cognitive abilities. Cross-species research sheds light on the origins of musicality by investigating whether these traits are shared…

uman skin equivalents (HSEs) are in vitro 3D-skin models that mimic many aspects of the native human skin (NHS) and can be a valuable tool.

Op 11 januari 2010 kondigde decaan Sjoerd Verduyn Lunel tijdens de nieuwjaarsreceptie het initiatief aan voor de bouw van een nieuwe campus voor de Faculteit der Wiskunde en Natuurwetenschappen.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

This thesis advances our understanding of lipid uptake, a vital first step in lipid metabolism, by developing innovative click chemistry-based tools to study how immune cells internalize lipids.

The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

Promotor: E.F. Smets Co-promotor: J. Geml

Promotor: M. Ubbink, Co-Promotor: R. T. Dame

Most of current public-key cryptography is considered insecure against attacks from sufficiently powerful quantum computers. Post-quantum cryptography studies methods to secure information resistant against such attacks. One proposal is isogeny-based cryptography, which bases its security on computational…

Het doel van dit promotieonderzoek was te onderzoeken wat leraren zelf willen leren. De centrale onderzoeksvraag luidde: wat, hoe en waarom willen leraren leren? En hangt dit af van hun jaren leservaring en de school waarin ze werken?

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

De motivatie van studenten van lerarenopleidingen voor het beroep van leraar is afhankelijk van diverse factoren. Lerarenopleidingen kunnen de betrokkenheid van hun studenten beïnvloeden.

Ontwikkeling van effectieve VR-training voor internationaal recht van gewapende conflicten (ILAC)

In this thesis, several aspects of software debugging from automated crash reproduction to bug report analysis and use of contracts have been studied.

Promotores: Prof.dr. S.J. Edixhoven, Prof.dr. E. Ullmo (University Paris-Sud)

Global Environmental Extensions Multi-Regional Input-Output (EE-MRIO) analysis is often used to analyze how changes in global and national demand for products lead to socioeconomic and environmental impacts at the national level.

In this thesis I highlight the applications of Oxford Nanopore Technologies (ONT) sequencing. This technique is a relatively new approach in the sequencing field, where nanopores are embedded in a membrane, DNA molecules are pulled through nanopores and an electrical current serving as the sequencing…

Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.

Een groep van meer dan honderd pro-Palestina demonstranten is dinsdag 6 mei rond 13.00 uur bijeengekomen in gebouw Wijnhaven op de Campus Den Haag. Deelnemers scandeerden leuzen en hingen spandoeken op. Het overgrote deel van de deelnemers van de actie heeft het gebouw na korte tijd weer verlaten. Een…

The overarching goal of this PhD thesis is to investigate the taxonomic and functional diversity of yeasts in the wheat phyllosphere and their interactions with the mycotoxigenic fungal pathogen Fusarium graminearum.

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…

De formele sleuteloverdracht van de eerste fase van de Science Campus vond plaats op 23 februari 2016.

Cynthia van Vonno, politicoloog aan de Universiteit Leiden, verklaart in haar proefschrift waarom individuele parlementariers meestemmen met hun fractie.

This course explains the functions of each international court and tribunal in The Hague. On the basis of cases and interviews with judges and lawyers, this course explores the role of these courts and tribunals and their potential to contribute to global justice.