Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Tracing the evolution of the molecular gas content in galaxies is critical for a complete understanding of galaxy formation and evolution, as it provides the direct fuel for star formation. Studies of high-redshift (z>1) molecular gas reservoirs, most commonly traced by carbon monoxide (CO), have seen…

Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.

The aim of this project was to estimate emissions from lead products-in-use for the past, the present and the future and assess the development of toxicological risks associated with these products.

Molecular materials have been a subject of interest in fundamental research and applications for decades, and have been studied as bulk crystals, (thin) films and as individual molecules, due to the large variety in their properties. This dissertation explores pentacene crystals near the two-dimensional…

Possible improvements for the assessment of abiotic depletion in LCA.

Het belangrijkste doel van dit onderzoek is om de steden van het Romeinse Nabije Oosten in de keizertijd in kaart te brengen, met een focus op locatie, stadsgrootte en stedelijke kenmerken, om de vorm van het stedelijke systeem en de niveaus van integratie te bestuderen.

uman skin equivalents (HSEs) are in vitro 3D-skin models that mimic many aspects of the native human skin (NHS) and can be a valuable tool.

Since its beginnings, Leiden University has been home to scholars with a broad and diverse expertise in the histories, languages, literatures and material cultures relevant to the study of Jews and Judaism from antiquity to modern times.

Description of Atlas of the surfacewater concentrations of pesticides in the Netherlands, a pilotstudy.

1) Assess the trends in supply and production status of these critical minerals and mineral products worldwide and Europe’s dependence including on intermediate products such as permanent magnets, RE based super alloys, batteries, polishing compounds, phosphors, catalysts etc. 2) Trace the entire value…

Examining the sustainability aspects of biotechnology, especially those related to the production of ethanol from biomass.

Wat zijn de belangrijkste thema's in het uitvoeren van systemen voor bio-energie ?

Description of 20th century changes in the Dutch flora: Description and interpretation (1999 - 2005)

Op 14 oktober 2021 is het publieksboek uitgekomen. Sindsdien kunnen alle bestanden en links via deze website geraadpleegd worden.

This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

A substance flow analysis, covering about 99 % of the flows of chlorinated substances in the Netherlands.

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

Promotor: G.A. Persoon, Co-promotor: H.H. de Iongh

CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…

Are there significant differences among the environmental impacts resulting form the production of Asian aquaculture commodities and what are the main causes for these?

This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.

The class-imbalance problem is a challenging classification task and is frequently encountered in real-world applications. Various techniques have been developed to improve the imbalanced classification performance theoretically and practically.

The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

The work described in this Thesis is focused on the assembly of oligosaccharide fragments derived from a fungal polysaccharide, galactosaminogalactan (GAG) and fragments of the exopolysaccharide Pel, generated by Pseudomonas aeruginosa.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Single-Molecule Microscopy (SMM) techniques constitute a group of powerful imaging tools that enable researchers to study the dynamic behavior of individual molecules.

An overview is given of the flows of chlorine and chlorinated hydrocarbons through the Europian Union.

Soil biodiversity is of great importance for the maintenance of multifunctionality in terrestrial ecosystems.

Promotor: M. Ubbink, Co-promotor: G. Siegal

In this Thesis, novel charge induction mechanisms of ionic liquids are treated, tested and experimented on complex oxides, in particular cuprates.

This book aims to be a point of reflection and debate for journalists, academics and students to recognize a fundamental task in the duty of the communications professional, which is to influence through their daily work and their routines in order to achieve a more inclusive and plural society, through…

Freshwater biodiversity has been threatened by eutrophication due to excessive nutrients in the environment. Releasing the freshwater species from such pressures requires efforts from industry and manufacturers to avoid emissions to vulnerable and high-risk regions.

The thesis deals with the study of giant radio galaxies (GRGs), which are radio galaxies of megaparsec sizes.

In Europe a number of production and communication strategies have long tried to establish local products as resources for local development. At the foot of the Alps, this scenario appears in all its contradictions, especially in relation to cheese production. The Heritage Arena focuses on the saga…

In this thesis, we have used numerical approaches to study the effects of translational symmetry breaking on strange metallic systems as realised by the holographic duality⁠.

In this study the flows of PVC and its additives through the Swedish Society were followed from the cradle to the grave (from production to waste treatment).

Zelfredzaamheid en sociale bescherming over de levenscyclus

My PhD research is devoted to studies of the conjectural cluster-algebraic symmetry in the theory of topological string, which is the simplest, however already non-trivial sector in the theory of string.

Promotor: Prof.dr. A.G.G.M. Tielens, Prof.dr. C. Dominik (UvA)

Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.

This thesis consists of two subjects, that are both a consequence of radiation pressure.