The energy system is at the heart of two of the greatest challenges of the 21st century: decreasing CO2 emissions to meet the ambitions of the Paris agreement while fulfilling the growing energy demand associated with the economic aspirations of a growing world population.

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf

This dissertation presents new cryptographic protocols, which can be divided into two families.

This thesis presents pioneering work on the panchromatic emission of some of the most luminous galaxies in the early Universe: star forming galaxies and active galactic nuclei.

The formation and evolution of galaxies is fundamentally driven by the formation of new stars out of cold gas.

Following the Big Bang, structure in the Universe started collapsing under the force of gravity. This resulted in the formation of the first stars, galaxies and clusters of galaxies.

The applications of studying the early development of insects range from agriculture to material science.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

Promotor: Prof.dr. B.R. Katzy

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

Optimization tasks in practice have multifaceted challenges as they are often black box, subject to multiple equality and inequality constraints and expensive to evaluate.

Promotores: W. Th. F. den Hollander, M.O. Heydenreich

Promotor: K.J. Batenburg

Promotor: Prof.dr. S.F. Portegies Zwart

Promotor: Prof.dr. T. Hankemeier

Promotores: P. Stevenhagen, E. Fouvry (Univeriste Paris Saclay)

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

The elementary excitations of magnets are called spin waves, and their corresponding quasi-particles are known as magnons. The rapidly growing field of Magnonics aims at using them as information carriers in a new generation of electronic devices, (almost) free of electric currents.

Promotor: Prof.dr. R.M.H. Merks

In this PhD-thesis several new and existing data science application are described that are particularly focused on applications for tax administrations.

This thesis describes the development and validation of new high-contrast imaging techniques, with the ultimate goal of enabling the next generation of instruments for ELT-class telescopes to directly image Earth-like extra-solar planets orbiting around nearby stars.

Promotor: Prof.dr. E. F. van Dishoeck

Radiography is an important technique to inspect objects, with applications in airports and hospitals. X-ray imaging is also essential in industry, for instance in food safety checks for the presence of foreign objects.

Promotor: Prof.dr. B.R. Katzy, Prof.dr. J. de Vries

Streptomyces are prolific producers of enzymes and secondary metabolites, including more than 50% of all clinical antibiotics. This makes them highly attractive for medical, biotechnological, and industrial purposes.

One of the key quests in astronomy is to study the growth and evolution of galaxies across cosmic time. Radio observations provide a powerful means of studying the formation of stars and subsequent buildup of distant galaxies, in a way that is unbiased by the presence of dust.

In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.

Promotor: Prof.dr. P.C. van Welzen

An interdisciplinary collection of the best international scholarship on Muslim youth.

Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)

Systems are called real-time systems, if the correctness of the system does not only depend on the correctness of the system output but also on whether the output is delivered on time.

The project

Heb je een vraag over het nieuwe Gorlaeus Gebouw?

During the summer, we organize a summer school for researchers who want to learn about communicating science to diverse audiences. The summer school is aimed at researchers in any career stage who are new to science communication. The Summer School is open for all disciplines in science, including social…

Individuen die werken in de publieke sector zien zichzelf geconfronteerd worden met tegenstrijdige waarden, tegenstrijdige eisen en de noodzaak van het dienen van het soms moeilijk definieerbare publieke belang.

In this course, you will explore the organs involved in our food digestion and discover the common causes of abdominal and pelvic pain. The latest graphics and animations will give you new insights and understandings of this part of the body.

Dit boek neemt je stapsgewijs mee in het schrijven van een scriptie, met (voornamelijk) een focus op experimenteel onderzoek, dat het meest veel voorkomt. Door de stappen van experimenteel onderzoek in chronologische volgorde op te splitsen en bij elke stap tips te geven, hopen de auteurs enig houvast…

This Thesis describes the synthesis of D-alanylated ribitol-based wall teichoic acids from S. aureus to probe their interaction with immune-binding partners.

Promotor: Arjen Doelman, Co-promotor: Vivi Rottschäfer

What are the pressing issues of our time, and how can different disciplines come together to address them? Studium Generale and Leiden University College (LUC) present the Global Challenges series: events that bring together researchers from LUC and experts from other disciplines to tackle a shared…

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

Machine Learning is becoming a more and more substantial technology for industry.

Synthetic microswimmers take an important place within the interdisciplinary field of active soft matter.

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

The origin and evolution of galaxies are closely tied to the cyclic feedback processes between stars and the interstellar medium (ISM).

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.