963 zoekresultaten voor “parkinson s disease” in de Publieke website
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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Visual analytics for spatially-resolved omics data at single cell resolution: Methods and Applications
The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…
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Lipid signaling and inflammation: metabolomics for better diagnosis and treatment strategy
Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…
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Fluorescence Polarization Activity-Based Protein Profiling on Retaining Glycosidases
Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.
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B cell modulation in atherosclerosis
Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.
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Development of personalized health monitoring using ultra-weak photon emission based on systems medicine concepts
Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk
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Exploring chemical space in covalent and competitive glycosidase inhibitor design
Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency
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Involvement of host and bacterial factors in Agrobacterium-mediated transformation
Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.
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Chemical genetic approaches for target validation
Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.
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Design and development of conformational inhibitors and activity-based probes for retaining glycosidases
Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.
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Ahmed Mahfouz: 'Het mysterie van hersenziekten, cel voor cel uitgezocht'
Welke hersencel doet wát als bijvoorbeeld de ziekte van Parkinson ontstaat? Het duurt niet lang meer voordat die puzzel stukje voor stukje gelegd kan worden. Computationeel bioloog Ahmed Mahfouz combineert Leidse bio-kennis met Delftse algoritmen en komt steeds dichterbij de sleutel.
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gebruikersvoorwaarden pianostudio's
Gebruikersvoorwaarden met betrekking tot het gebruik van LAK cursusruimtes in het Lipsius.
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Capillary Electrophoresis-Mass Spectrometry based Metabolomics Approaches for Volume-restricted Applications
Metabolomics is a powerful tool that can provide a comprehensive insight into the complexity of human biology and the pathophysiology of diseases. By analyzing the metabolome, which refers to the complete set of small (endogenous) molecules (with a mass <1500 Da) present within a given biological system,…
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Children’s Rights in International Commercial Surrogacy
Op 26 juni 2018 verdedigde Claire Achmad haar proefschrift 'Children’s Rights in International Commercial Surrogacy: Exploring the Challenges from a Child Rights, Public International Law Perspective'. Het promotieonderzoek is begeleid door promotor prof. mr. drs. M.R. Bruning.
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Nieuw project om ziekte van Alzheimer te bestuderen
Onderzoekers van de Universiteit Leiden gaan een nieuwe manier ontwikkelen om de biomarkers van de ziekte van Alzheimer te bestuderen. De aanpak focust zich op de moleculaire boodschappers van de cellen. Het project, geleid door Thomas Hankemeier en gecoördineerd door Yuliya Shakalisava (Leiden Academic…
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International Children’s Rights (Advanced LL.M.)
Leiden University’s Master of Laws in International Children’s Rights (LL.M.) looks at human rights laws for children from a comparative perspective.
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Healthy elderly in clinical trials: how to define preclinical Alzheimer’s Disease for clinical trial participation
Promotie
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The Global Future(s) of Europe
Oratie
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NWO-beurs drijft zoektocht naar duurzame productie antibiotica
De kans om een nieuw, spannend onderwerp te onderzoeken. Dat is hoe Lennart Schada von Borzyskowski zijn succesvolle beursaanvraag voor de NWO XS-beurs noemt. Deze 50.000 euro zal de onderzoeker van het Instituut Biologie Leiden (IBL) spenderen aan het ontwikkelen van een nieuwe methode om op duurzame…
- Zwarte gaten en kosmische neutrino's
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Multifaceted role of the complement system in health and disease
Promotie
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Role of intestinal microbiota in cardio-metabolic disease
Promotie
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Single-cell mechanics for disease biology and pharmacology
Promotie
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Advanced echocardiographic imaging in valvular and systemic diseases
Promotie
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Early diagnosis and management of celiac disease in childhood
Promotie
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Pharmacotherapy and Ventilatory Control in Health and Disease
Promotie
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Oxidative Stress in Chronic Diseases: Causal Inference from Observational Studies
Promotie
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Oxidants and antioxidants as targets for cardiovascular disease prevention
Promotie
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Viral gene therapy approaches for CRB1 retinal disease
Promotie
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Genetics and Life Course Epidemiology of Cardiometabolic Disease
Promotie
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4D-Flow MRI of Aortic and Valvular Disease
Promotie
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Developmental cell lineage dynamics in Bicuspid Aortic Valve disease
Promotie
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From data to models: reducing uncertainty in benefit risk assessment: application to chronic iron overload in children
Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua
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Unraveling temporal processes using probabilistic graphical models
Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.
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Boosting the host immune system to fight tuberculosis
New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.
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Evolutionary adaptability of β-lactamase: a study of inhibitor susceptibility in various model systems
β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…
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Transcultural Health Care Utilisation in Serengeti of Tanzania: Towards Applied Ethnoscience in Public Health Management
The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.
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Vaccination and Targeted Therapy Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.
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A novel formulation for skin barrier repair : from ex vivo assessment towards clinical studies
The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.
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Strategies to Investigate Lipoprotein Metabolism and Combat Cardiometabolic Disease
Promotie
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Het welbevinden van baby's en peuters
Wat is het beste voor een baby of peuter: veel of juist weinig herrie in een kinderdagverblijf? Het onderzoek van pedagoge Claudia Werner toont aan dat kleine kinderen bij een beetje lawaai zich het meest op hun gemak voelen. Bij dit soort onderzoek is de keuze van de analysemethode zeer belangrijk.…
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Spinoza's Theory of Religion: The Importance of Religion in Spinoza's Thought and Its Implications for State and Society
Op 23 oktober 2019 verdedigde Yoram Stein zijn proefschrift 'Spinoza's Theory of Religion: The Importance of Religion in Spinoza's Thought and Its Implications for State and Society'. Het promotieonderzoek is begeleid door promotor prof.dr. P.B. Cliteur en prof.dr. A.A.M. Kinneging.
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Samenwerking start zoektocht voor nieuwe antibiotica met NWO beurs
Nieuwe stoffen identificeren om antibioticaresistente bacteriën te bestrijden. Onderzoekers van Leiden Universiteit en VU Amsterdam bundelen hun krachten om dit waar te maken, met een project gefinancierd door NWO’s Open Technologieprogramma (OTP). De samenwerking heeft bijna een miljoen euro toegekend…
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Constructing an ‘emotional community’ in times of crisis: the EU’s response to Russia’s invasion of Ukraine in 2022
Emoties spelen een cruciale rol in de EU-politiek. Dit artikel onderzoekt hoe emoties de EU-reactie op internationale crises door normovertredingen beïnvloeden.
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Temminck's Order. Debates on Zoological Classification: 1800-1850
“Temminck’s Order” is the scientific biography of Coenraad Jacob Temminck (1778–1850), a Dutch naturalist and the first director of ’s Rijks Museum van Natuurlijke Historie in Leiden.
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Algorithm for Structural Variant Detection
Structural variants (SVs) are the hidden architecture of the human genome, and are critical for us to understand diseases, evolution, and so on.
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IBL Spotlights
Tijdens de IBL Spotlights bespreken onderzoekers van de afdeling Science Communication & Society hun nieuwste bevindingen en realisaties. Na de lezingen ben je welkom bij de borrel op de eerste verdieping van het Sylviusgebouw.
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Inverse design of curvature-sensing antiviral peptides
Viral diseases constitute one of the major challenges in modern medicine. Membrane-targeting have broad-spectrum potential and could distinguish viral membranes from the host cell plasma membrane by the difference in membrane curvature.
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Modern Drug Discovery
How are new drugs developed? This question is central to the Minor Modern Drug Discovery (MDD), which covers the entire trajectory from disease to drug molecule and vice versa. The various research groups involved offer a complementary and interdisciplinary perspective by connecting the diverse subjects…
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Gauss's theorem on sums of 3 squares, sheaves, and Gauss composition
Promotor: Bas Edixhoven, Promotor: Qing Liu