1,269 zoekresultaten voor “state cell differentiation” in de Publieke website
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Summer Course: Europeanisation of Administrative Law in the Member States
Van 26 t/m 30 juni 2017 organiseert de afdeling Staats- en Bestuursrecht van de Universiteit Leiden een zomercursus over de Europeanisering van het nationaal bestuursrecht in de lidstaten van de Europese Unie.
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Ymre Schuurmans benoemd in externe commissie reflectie Raad van State in toeslagenaffaire
De Raad van State heeft een programma van reflectie opgesteld, waarmee de hoogste bestuursrechter zijn aandeel in de kindertoeslagaffaire wil evalueren om lessen uit de affaire te kunnen trekken.
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Gene regulation in embryonic development
The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.
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Intradermal delivery of nanoparticulate vaccines using coated and hollow microneedles
In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.
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The innate immune response against mycobacterial infection: analysis by a combination of light and electron microscopy
Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf
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Customary International Criminal Law and Head of State Immunity by Judge Chile Eboe-Osuji
On 12 September 2019, Judge Chile Eboe-Osuji, President of the International Criminal Court (ICC), delivered a lecture on Customary International Criminal Law and Head of State Immunity to open the academic year for the Advanced LL.M. Programmes in Public International Law & International Dispute Settlement…
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Jorrit Rijpma spreekt op de jaarlijkse State of the Art Conference in Den Haag
Op 14 november organiseerde het Team Strategie & Verbinding van het DG Migratie van het Ministerie van Justitie en Veiligheid de jaarlijks de State of the Art conferentie. De conferentie brengt wetenschappers, beleidsmakers en andere professionals in het migratiedomein bijeen rond belangrijke migratievraagstukken.…
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slag als hoofd kennisunit directie Bestuursrechtspraak van de Raad van State
Per 20 augustus gaat universitair hoofddocent Michiel Tjepkema aan de slag bij de directie Bestuursrechtspraak van de Raad van State. Hij wordt het eerste hoofd van de kennisunit.
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Atom addition reactions in interstellar ice - new pathways towards molecular complexity in space -
Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: S. Ioppolo, H.M. Cuppen
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Enumeration and Simulation of Lattice Polymers as Models for Compact Biological Macromolecules
Promotores: H. Schiessel, G.T. Barkema
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Carola Schoor op Politico over de State of the European Union speech
Carola Schoor, programmaleider Public Affairs bij het Centre for Professional Learning (CPL), reflecteert op Politico op de State of the European Union speech door Ursula von der Leyen, president van de Europese Commissie.
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Novel analytical approaches to characterize particles in biopharmaceuticals
Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).
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Cell Pharmacy
Oratie
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Innovating Cell Pharmacy with stem cells
Lezing, NGL-lezing
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Hossam Ahmed: ‘Luister naar je studenten’
Drie docenten van Geesteswetenschappen ontvingen dit jaar de Senior Kwalificatie Onderwijs (SKO). Docent Hossam Ahmed is een van hen. Wat maakt onderwijs volgens hem goed?
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The formation of complex organic molecules in dense clouds-Sweet results from laboratory
Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.
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Leiden Leadership Lunch: State of the Art Crisisbeheersing: Implicaties voor Leiderschap
Wat kunnen publieke leiders leren van crisismanagement? In de tweede Leiden Leadership Lunch in de serie ‘Leiderschapskansen in tijden van crisis’ deelden Dr. Jaap van Lakerveld en Dr. Jeroen Wolbers – experts op het gebied van crisismanagement – enkele inzichten uit het recent gepubliceerde rapport…
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Shockerende state of being: een PRE-Class presentatie over kwantummechanica
‘Anyone who has not been shocked by quantum mechanics has not understood it.’ Verwonder jij je ook niet dagelijks over kwantummechanica en de state of being van atomen? Volgens natuurkundige Niels Bohr, een van de grondleggers van de kwantummechanica, begrijp je dan gewoon nog niet genoeg van dit bijzondere…
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Metals in LCIA
A critical look at the impact assessment modelling of metals in Life Cycle Impact Assessment and improvement options.
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Regulation of actomyosin contraction as a driving force of invasive lobular breast cancer
In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).
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Personalised medicine for multiple outcomes: methods and application
The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.
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Towards photo-CIDNP MAS NMR as a generally applicable enhancement method
Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)
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in Nieuwsuur over de gevolgen van de PAS-uitspraak van de Raad van State
Rogier Kegge, universitair docent bestuursrecht en omgevingsrecht, vertelt in Nieuwsuur over de verstrekkende gevolgen van de uitspraak van de Afdeling Bestuursrechtspraak van de Raad van State van 29 mei 2019 (ECLI:NL:RVS:2019:1603) over het Programma Aanpak Stikstof.
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Single-molecule fluorescence in sequence space
The sequence-dependence of biomolecular interactions involving nucleic acids and proteins is essential for numerous processes inside the cell. Insights into the underlying molecular mechanisms have been obtained using various biochemical and biophysical methods on two different levels — bulk and sin…
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The shell evolution of the Hydrocenidae of Malaysian Borneo
The thesis is about the study of shell evolution of the Hydrocenidae of the genus Georissa. This thesis started with a general overview on the evolutionary process of animals due to ecological changes.
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On the optimization of imaging pipelines
In this thesis, topics relating to the optimization of high-throughput pipelines used for imaging are discussed. In particular, different levels of implementation, i.e., conceptual, software, and hardware, are discussed and the thesis outlines how advances on each level need to be made to make gains…
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Liberalisering en privatisering in het bestuursrecht bij de Raad van State
Vrijdag 28 oktober 2016 vond op de Raad van State het symposium ‘De gevolgen van privatisering en liberalisering voor de rechtsbescherming door de bestuursrechter’ plaats. De Afdeling Staats- en bestuursrecht van de Universiteit Leiden en de Raad van State organiseerden gezamenlijk dit symposium, ter…
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Tenosynovial Giant Cell Tumours
Promotie
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On transport properties of Majorana fermions in superconductors: free & interacting
Majorana fermions in superconductors are the subgap quasiparticle excitations that are their own antiparticles.
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neemt in november 2019 deel aan conferentie Who Owns the World? The State of Platform Cooperativism
Morshed Mannan presenteerde onder andere zijn artikel dat deel uitmaakt van zijn proefschrift met de titel ‘Everything Old is New Again: Evaluating the Legal and Governance Structures of Emergent Protocol Cooperatives’.
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Gold nanoparticle-peptide conjugates for biomedical applications
Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.
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EMStaD JEMEN: Ontwikkeling van een vroegmoderne staat in Jemen
Hoe zorgen vroegmoderne staten voor effectief bestuur in moeilijke omstandigheden? In EMStaD JEMEN staat een land centraal dat vanwege zijn geografische, religieuze en sociale complexiteit tegenwoordig wordt beschouwd als een failed state: Jemen.
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The heart of oxygenic photosynthesis illuminated
Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia
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RNA splicing in breast cancer progression
In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.
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Physics implications of shape on biological function
Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.
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Novel factors modulating AGC kinase signaling-controlled polar auxin transport
The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.
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Unravelling cell fate decisions through single cell methods and mathematical models
Promotie
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Growth-induced self-organization in bacterial colonies
Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.
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Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.
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Sensing Transport
Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.
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TCRs as Precision Tools against B-cell and Plasma Cell Malignancies
Promotie
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Learning cell identities and (post)-transcriptional regulation using single- cell data
Promotie
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of metabolic pathways and sensors in regulation of dendritic cell- driven T cell responses
Promotie
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Paul van TrigtFaculteit der Geesteswetenschappen
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Systems microscopy to unravel cellular stress response signalling in drug induced liver injury
Promotor: B. van de Water
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Composition and function of integrin adhesions
Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.
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Spatio-temporal aspects of antigen cross-presentation in dendritic cells: with click-to-release chemistry
The first steps are made in personalised cancer vaccination strategies, which aim to induce a more specific immune response with fewer side effects. The activation of cytotoxic T cells is crucial for an effective immune response.
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Analysis of sub-visible particles in complex injectable formulations
Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik
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Phase separation in lipid-based nanoparticles: exploring the nano-bio interface
This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.
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GLOBOX
GLOBOX is a spatially differentiated multimedia fate, exposure and effect model. It is used for the calculation of spatially differentiated LCA characterisation factors on a global scale.