Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.

Identification of the products or product groups that have the greatest environmental impact from a life-cycle perspective using environmentally extended input-output analysis.

Dit artikel onderzoekt de clusters van crisiscommunicatieonderzoek in de literatuur, waarbij overlappingen en raakvlakken tussen verschillende vakgebieden worden onderzocht.

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Geesteswetenschappen, Centre for Linguistics

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…

Heterogeneous catalysis is one of the fundamental processes of modern life, being common in industrial refinery and hydrogen vehicles, all the way to the living cell. The dissociation of H2 on Cu(111) is an important benchmark system for studying heterogeneous catalysis, with a large and varied amount…

The high velocity tail of the total velocity distribution of stars provides essential insight into fundamental properties of the Galaxy.

The thesis is about the study of shell evolution of the Hydrocenidae of the genus Georissa. This thesis started with a general overview on the evolutionary process of animals due to ecological changes.

Promotor: W. Jaffe, Co-promotor: K. Meisenheimer

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

Promotor: P. T. de Zeeuw, Co-promotor: N. Neumayer; G. van de Ven

Promotor: E.F. Smets, Co-promotor: J. Geml

How can we bridge the gap between experts and the general public?

What is the role of the rebound effect in achieving environmental savings from transport eco-innovation? Are traditional definitions of the rebound effect adequate in the context of transformative innovations and multidimensional environmental issues?

Promotor: Johan Kuiper, Co-promotor: Saskia C.A. de Jager

Promotores: Prof.dr. J. Schaye, Prof.dr. S.D.M. White (MPA Garching)

The haplolepideous mosses (Dicranidae) comprise about 4000 species distributed over a wide range of habitats, with great gametophytic and sporophytic morphological variation. Their monophyly is well supported by the results of several molecular phylogenetic studies, which shed light on their relationships…

Promotor: Prof.dr. G.R. de Snoo, Co-promotor: R. Heijungs

The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

Accumulation of metals in economy and environment and its associated risks, within the Netherlands and the EU.

What is the current relevance of the ethics of counterterrorism and what is the added value of ethics support within the practice of counterterrorism?

A substance flow analysis, covering about 99 % of the flows of chlorinated substances in the Netherlands.

What are trait-trait relationships in wetlands? To what extent the so-called leaf economics traits deviate from terrestrial ecosystems? How traits specific to wetland plant relate to plant strategies? What’s the relationship between wetland plant traits to the ecosystem functioning (e.g. productivity,…

This thesis develops a method for direction dependent calibration of the ionosphere in radio interferometric data.

Sobral

At the largest scales, two ingredients dictate the distribution of matter in the Universe. The first is dark matter, acting as an invisible scaffolding held together by gravitational forces.

Op 3 september 2019 verdedigde Ilektra Antonaki haar proefschrift 'Privatisations and golden shares: Bridging the gap between the State and the market in the area of free movement of capital in the EU'. Het promotieonderzoek is begeleid door promotor prof.dr. S.C.G. Van den Bogaert.

Op 15 februari 2022 verdedigde Morshed Mannan het proefschrift 'The Emergence of Democratic Firms in the Platform Economy: Drivers, Obstacles, and the Path Ahead'. Het promotieonderzoek is begeleid door prof.mr. I.S. Wuisman en prof.dr. J.A.A. Adriaanse.

Op 16 december 2019 verdedigde Jan-Harm de Villiers zijn proefschrift 'The Anthropomorphic Hegemony of Subjectivity: Critical Reflections on Law and the Question of the Animal'. Het promotieonderzoek is begeleid door promotor prof.dr. P. Cliteur.

The International Course on Water Use and Management in Cagayan Valley The Philippines (2011-2015)

The experiences of ethnic ‘Other’ females have – until recently – been widely overlooked in the study of sport. There continues to be a need to produce critical scholarship about ethnic 'Other' girls and women in sport and physical culture, in order to represent their complex, multifarious and dynamic…

Although nanoparticles are extensively used in various applications like consumer products and have most probably entered the environment, little is known about the effects of these particles on living organisms.

Op 16 december 2021 verdedigde Lisanne van Houten het proefschrift 'Flexing the Slot Regime'. Het promotieonderzoek is begeleid door prof.dr. P. Mendes de Leon en prof. L. Pierallini (Luiss University Of Rome).

The unit residue group, to which the present thesis is devoted, is defined using the norm-residue symbol, which Hilbert introduced into algebraic number theory in 1897.

What invertebrates live in the fields and edges? Do the populations change with landscape complexity?

Wat kunnen de talen die vandaag gesproken worden op de Kleine Soenda-eilanden ons vertellen over de geschiedenis van de verschillende bevolkingsgroepen?

In Europe a number of production and communication strategies have long tried to establish local products as resources for local development. At the foot of the Alps, this scenario appears in all its contradictions, especially in relation to cheese production. The Heritage Arena focuses on the saga…

Enkele keren per jaar organiseert het Europa Instituut een ‘Meet the Author’ bijeenkomst. In het kader van deze nieuwe lezingenreeks komen externe academici naar Leiden om te spreken over een recente publicatie. ‘Meet the Author’ bijeenkomsten vangen aan met een gesprek tussen een lid van het Europa…

Op 31 januari 2018 verdedigde Vestert Borger zijn proefschrift getiteld ‘The Transformation of the Euro: Law, Contract, Solidarity’. Het promotieonderzoek is begeleid door professor Stefaan Van den Bogaert (promotor) en dr. Jorrit Rijpma (co-promotor).

What are the flows of C&DW (e.g. bricks, concrete, gypsum and wood) in the case study countries ? How to define the specification for each material to be quantified? What indicators should be used to identify the pattern of each C&DW management system? How to interpret the MFA results in relation…

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.

Promotor: Prof.dr. S.F. Portegies Zwart

Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros

This pioneering project will answer this question by examining migrants through the eyes of the courts between 1600 and 1900. It aims to reveal patterns of continuity and change in: 1. Treatment of migrants by criminal courts; 2. Violence and conflicts between migrants and native born.

Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).