1,214 zoekresultaten voor “this work e2 80 99s discovery” in de Publieke website
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NMR structural studies of protein-small molecule interactions
Promotor: Prof.dr. M. Ubbink, Co-promotor: G. Siegal
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Astronoom Joe Callingham getuigt tegen killer-sterren in nieuwe show op Discovery
Op vrijdagavond 17 september is de Leidse astronoom Joe Callingham te zien in een nieuwe serie op Discovery. ‘Killers of The Cosmos’ gaat over krachten in het heelal die ons bestaan kunnen bedreigen. Asteroïden, kosmisch puin, elektromagnetische wapens… De show behandelt elke bedreiging als potentiële…
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NMR studies of protein-small molecule and protein-peptide interactions
Promotor: M. Ubbink, Co-promotor: G. Siegal
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Mechanistic modelling of drug target binding kinetics as determinant of the time course of drug action in vivo
Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.
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Karin van der Hiele
Faculteit der Sociale Wetenschappen
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Towards improved drug action : target binding kinetics and functional efficacy at the mGlu2 receptor
During the course of drug discovery translational steps are made.
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Sensing Transport
Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.
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Chemical tools to study the cannabinoid receptor type 2
The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…
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PhD: Targeting electron transport chain in Listeria monocytogenes for novel antibiotic development
Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)
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Presentatie masterscriptie tijdens conferentie Reshaping Work
Francine van Vlijmen, net afgestudeerd in Staats- en Bestuursrecht aan de Universiteit Leiden, heeft op 20 oktober een poster-presentatie gegeven tijdens de conferentie “Reshaping Work in the Sharing Economy” in Amsterdam.
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Quantitative pharmacological modelling for optimizing treatment of sepsis
Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…
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Publicatie artikel “Social support at work and at home: Dual-buffering effects in the work-family conflict process”
Dr. Helen Pluut heeft een artikel gepubliceerd in het gerenommeerde tijdschrift Organizational Behavior and Human Decision Processes (OBHDP) in samenwerking met Remus Ilies (National University of Singapore), Petru Curşeu (Open Universiteit en Babeş-Bolyai University) en Yukun Liu (University of Western…
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Fluorescence Polarization Activity-Based Protein Profiling on Retaining Glycosidases
Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.
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Universiteit Leiden digitaliseert 80.000 pagina’s middeleeuwse handschriften
Universitaire Bibliotheken Leiden en uitgeverij Brill hebben een van de topcollecties van de Universiteit Leiden gedigitaliseerd en beschikbaar gesteld als online publicatie: Codices Vossiani Latini Online.
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De onzichtbare last van cognitieve problemen bij multipele sclerose
Van de patiënten met multipele sclerose (MS) krijgt 34-65% vroeg of laat te maken met cognitieve problemen.
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This is life: some thoughts on self-organized structure formation in active liquids and biological systems
It has been a long-standing mystery how complex biological structures emerge from such seemingly uncoordinated building blocks as cells and tissues, in the presence of only minimal environmental guidance.
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Medical Delta café: translation models for drug discovery and development, 8 oktober 2013
Onze gemiddelde leeftijd gaat omhoog en de behoefte naar goede gezondheidszorg wordt steeds groter. Nieuwe medicijnen moeten op de markt komen maar kosten voor de ontwikkeling daarvan moeten omlaag. Tijdens het Medical Delta café op 8 oktober presenteren o.a. dr. Leo Price, dr. Jan de Sonneville en…
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Illuminating N-acylethanolamine biosynthesis with new chemical tools
In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.
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Environmental and metabolomic study of antibiotic production by actinomycetes
Promotor: Prof.dr. G.P. van Wezel
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Affinity-based profiling of the adenosine receptors
The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.
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Micro-organismen bloeien op na 80.000 jaar op de zeebodem
Op de vrijwel energieloze bodem van de zee hebben onderzoekers oases gevonden waar micro-organismen toch energie kunnen benutten. Opmerkelijk is dat deze daarvoor eerst 80.000 jaar lang begraven moeten zijn geweest in uiterst karige omstandigheden. Een internationale groep onderzoekers, onder wie José…
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Weidong Zhang over het bereiken van 'decent work' in China
Op 23 maart 2023 verdedigde Weidong Zhang in Leiden zijn proefschrift over het bereiken van 'decent work' in China. Dit onderzoek analyseert in hoeverre China fatsoenlijk werk bereikt aan de hand van een casestudy over fatsoenlijke werktijden. Het woord 'bereiken' benadrukt dat China nog bezig is dit…
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Jorrit Rijpma bij Working Group on Frontex Scrutiny, Europees Parlement
Op vrijdag 23 april verscheen Jorrit Rijpma voor de Working Group on Frontex Scrutiny van het Europees Parlement. Deze werkgroep is opgericht door de Commissie burgerlijke vrijheden, justitie en binnenlandse zaken (LIBE) van het Europees Parlement, als reactie op de beschuldigingen van serieuze schendingen…
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MOOC: EU Policy and implementation: making Europe work!
Mooc Eu Policy Europe Europa
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Chemical genetic approaches for target validation
Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.
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Light Weighed: On the Statistics and Systematics of Weak Gravitational Lensing
In astronomy, the interpration of observations and measurements plays a crucial role: we rely purely and fundamentally on the information that reaches us as observers. And 80% of all matter in the universe is undetectable directly.
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Analytical chemistry and biochemistry of glycosphingolipids: new developments and insights
Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…
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Hunting dark matter with X-rays
Promotor: A. Achúcarro Co-promotor: A. Boyarsky
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Chemical tools to monitor and control proteasome activities
Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea
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Nanofluidic tools for bioanalysis : the large advantages of the nano-scale
Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)
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Regulation of autophagy-related mechanisms during bacterial infection
Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.
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Mario van der Stelt
Wiskunde en Natuurwetenschappen
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Understanding functional dynamics and conformational stability of beta-glycosidases
Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.
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Lava worlds: characterising atmospheres of impossible nature
Over the last three decades, the discovery of exoplanets has revealed the boundless variety of worlds beyond our own Solar System. Majority of planetary systems contain short-period planets that are larger than Earth but smaller than Neptune.
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Tineke Rutgers
Bestuursbureau
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Ine Alberts
Bestuursbureau
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Small changes for long term impact: optimization of structure kinetic properties: a case of CCR2 antagonists
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman
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Nieuw artikel van Helen Pluut in European Journal of Work and Organizational Psychology
Een nieuw artikel van Dr. Helen Pluut zal verschijnen in European Journal of Work and Organizational Psychology. Het artikel, dat samen met Marion Büttgen en Jan Ullrich van de Universiteit van Hohenheim is geschreven, heeft implicaties voor organisaties die een duaal laddersysteem hanteren. Zulke systemen…
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Plan B for particle physics: finding long lived particles at CERN
This thesis discusses the discovery potential of Intensity Frontier experiments.
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Structural and functional analysis of proteins involved in natural product biosynthesis and morphological differentiation in Streptomyces
Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.
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Time is of the essence: investigating kinetic interactions between drug, endogenous neuropeptides and receptor
Promotor: A.P. IJzerman Co-promotor: L.H. Heitman
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Phenotypic screening with 3D cell-based assays
Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.
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Ecology and genomics of Actinobacteria and their specialised metabolism
Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.
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The activation mechanisms of G protein-coupled receptors: the case of the adenosine A2B and HCA2/3 receptors
Promotor: A.P. IJzerman
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op het internationale congres 'Labour2030 - Rethinking the future of work'
Het congres vond op 13 en 14 juli in Porto plaats en was tweetalig met simultane vertalingen tussen Engels en Portugees/Spaans. In totaal waren er ong. 350 deelnemers, uit 23 verschillende landen, waarvan de meeste deelnemers afkomstig waren uit Portugal, Spanje en Latijns Amerika (Argentinië, Bolivia,…
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To explore the drug space smarter: Artificial intelligence in drug design for G protein-coupled receptors
Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…
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Glycoproteomics assays for prostate cancer biomarker discovery
Promotie
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Drug-target residence time: a case for the adenosine A1 and A2A receptors
Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman
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Spectroscopic characterization of exoplanets: From LOUPE to SINFONI
Over the past years it has been discovered that the population of extra-solar planets is large and diverse.
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Witnessing the Process of Bacterial Cell Death: Novel Antimicrobials and Their Mechanisms of Action
This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…