Op 31 januari 2024 verdedigde Alex Schilin zijn proefschrift 'United in Distinctiveness: The Institutionalisation of Differentiated Integration in Economic and Monetary Union during the Sovereign Debt Crisis'. Wat motiveerde hem om dit onderwerp te onderzoeken en hoe heeft hij dit project aangepakt?…

Houd meer rekening met de verschillen tussen gemeenten. Daarvoor pleit Geerten Boogaard, bijzonder hoogleraar Decentrale overheden. De Gemeentewet zou, bijvoorbeeld ten aanzien van een gekozen burgemeester, een keuzemenu kunnen aanbieden. Boogaard houdt zijn oratie op 6 maart.

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

Promotie

Details kunnen zien van een zieke of gezonde cel, dat is mogelijk met de supermicroscoop van het consortium Cyttron. Niet alleen de microscoop is vernieuwend in zijn soort: ook de vorm waarop de partijen samenwerken past in de huidige tijd. “Toegang tot elkaars techniek, daar draait het om in ons samenwerkingsverband”,…

Met de nodige maatregelen starten onderzoekers hun werkzaamheden in verschillende laboratoria weer deels op. Het Leidse Cell Observatory is één van de plekken waar wetenschappers sinds 11 mei hun labwerk hervatten.

Promotor: Prof.dr. T. Schmidt

Promotor: Prof.dr. G.P. van Wezel

Healthy aging is one of the prime goals in today's society and atherosclerosis is among the greatest causes of morbidity in elderly. Cardiovascular disease patients receiving treatment are often of advanced aged and have an aged immune system, which limits translating experimental findings to the pa…

Promotor: Prof.dr. J. Kuiper

This thesis describes our search to identify and understand possible regulatory mechanisms of integrin α6β4 in cell-matrix adhesion and intracelular signaling.

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

Scattering of light in the presence of nano-structured materials, i.e. with features in the order of the wavelength of the light or smaller, reveals details of how light interacts with matter at the nanoscale.

Promotor: Prof.dr. R.M.H. Merks

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Onderwijsvernieuwingen komen en gaan, maar er is één onderwijsideaal dat altijd zal blijven bestaan: studenten uitdagen op hun eigen niveau om diepgaand na te denken over en met de leerstof.

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf

Juist bij het vak Engels in het tweetalig onderwijs is er sprake van grote onderlinge niveauverschillen tussen leerlingen. Deze leerlingen moeten snel op een hoog niveau worden gebracht om de vakken te kunnen volgen die in het Engels gegeven worden. Ook zijn de eisen die worden gesteld aan het vak Engels…

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Wat is het effect van digitale leeskilometers op de leesvaardigheid van beginnende lezers in groep 3?

Ontdek de cursus Stralingsbescherming voor nucleair radiologen van Boerhaave Nascoling en leer over stralingsdeskundigheid. Lees hier meer!

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

Promotie

Naar zelfregulerend leren bij spreek- en gespreksvaardigheid in moderne vreemde talen in het voortgezet onderwijs: een adaptieve en praktische aanpak.

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

De studieonderdelen die betrekking hebben op het functioneren van studenten in de onderwijspraktijk zijn Praktijk 1 (eerste deel van de opleiding) en Praktijk 2 (tweede deel van de opleiding).

Didactiek

Promotor: Prof.dr. P. Hooykaas, Co-promotor: R. Offringa

Dit onderzoek richt zich op het proces waarmee docenten eigen lespraktijk stapsgewijs kunnen aanpassen in de richting van activerende didactiek en gedifferentieerd onderwijs.

Promotor: B. van de Water

Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

The first steps are made in personalised cancer vaccination strategies, which aim to induce a more specific immune response with fewer side effects. The activation of cytotoxic T cells is crucial for an effective immune response.