Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.

Als je ambtenaar wordt, veranderen daarmee jouw politieke opvattingen en gedrag? Hebben leraren in het openbare onderwijs dezelfde normen als andere professionals en de Braziliaanse bevolking als geheel?

Vanaf de koloniale tijd tot heden hebben grote aantallen Javanen hun woonplaats verlaten om zich in andere delen van Indonesië of veel verder weg te vestigen. Vaak was deze spreiding gedwongen, vaak met traumatische gevolgen.

Over the past years it has been discovered that the population of extra-solar planets is large and diverse.

Promotor: Prof.dr. A.G.G.M. Tielens, Prof.dr. C. Dominik (UvA)

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

This dissertation presents new cryptographic protocols, which can be divided into two families.

This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

Promotor: H.J.A. Röttgering, Co-promotor: M. Haverkorn

Throughout the history of computer science, a major challenge has been how to assert that software is free of bugs and works as intended. Software bugs can lead to serious negative impacts on any software system. Throughout the main body of the thesis, we implemented a series of studies on exploring…

Promotores: Prof.dr. J. Zaanen, Prof.dr. K.E. Schalm

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

De Russische schrijver en cardioloog Maxim Osipov komt een jaar lang naar Nederland om in Leiden college te geven over de Russische literatuur, zijn eigen werk en de politieke situatie in Rusland.

Stars like the sun are born in large molecular clouds existing from gas and dust. During the formation process, the chemical composition of the material can be altered drastically by the changing physical conditions.

Developing robust algorithms and theory for establishing cause-effect relationships from observational data that scale up to large data sets

In our research protein translocation from Agrobacterium into yeast and plant cells is studied to obtain fundamental insights in the translocation process

Promotores: Prof.dr. M. Franx, Prof.dr. P.G. van Dokkum (Yale University)

Hydrocarbonylation of alkenes with carboxylic acids in synthesis of carboxylic acid anhydrides is relatively less explored. We herein present a study and optimization of a palladium-catalyzed hydrocarbonylation reaction of alkenes using carboxylic acids as the nucleophile, by which acid anhydrides can…

The marine shipping industry is one of the strongest emitters of nitrogen oxides (NOx), a pollutant detrimental to ecology and human health. Over the last 20 years, the pollution produced by power plants, the industry sector, and cars has been decreasing.

The class-imbalance problem is a challenging classification task and is frequently encountered in real-world applications. Various techniques have been developed to improve the imbalanced classification performance theoretically and practically.

De onstuitbare opmars van de N.V. Zuid-Korea

Promotor: Ronald Cramer, Co-promotor: Serge Fehr

Almost three years after receiving her honorary doctorate, Dr Graça Machel returned to Leiden University. Over the course of two days she spoke with students, researchers, and other interested persons, about human rights – particularly those of women and children – in a world in which these are continually…

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

Innovation plays an essential role in firms' competitiveness and long-term success. It varies from different types, ranging from run-of-the-mill innovation that brings incremental changes to existing technologies to radical innovation that breaks from existing trajectories.

The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.

Classical statistical methods, such as p-values, are difficult for researchers to apply correctly. They for example do not allow drawing conclusions from a study early, or for extending a study with extra research groups that want to make their data available later.

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: G.J. Herczeg

In this thesis, we have studied cell images from two types of cells, including pollen grains and the immune cells, neutrophils. These images are captured using a bright field microscope and a confocal microscope.

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

In 2014 viel Rusland Oekraïne binnen en bezette de Krim en zo’n tweeënhalf jaar geleden begon het een grootschalige invasie. Voor Oekraïne is het een oorlog. Maar Rusland noemt het een “speciale militaire operatie”. Dergelijke woordkeuzes sturen de manier waarop mensen tegen zaken aankijken. Voor een…

This initiative is intended to support generative research collaborations between and among scholars located in different geographical regions who wish to pursue focused, joint projects in any area of the study of religion.

Promotor: J.S. Kaastra Co-promotor: E. Constantini

What Determines Perceptions of Bias toward the International Criminal Court? Evidence from Kenya. In dit artikel, gepubliceerd in op de website SAGE Journals in het Journal of Conflict Resolution, onderzoeken de auteurs Geoff Dancy, Yvonne Marie Dutton, Tessa Alleblas, Eamon Aloyo de houding ten opzichte…

Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

In this course, you will explore the organs involved in our food digestion and discover the common causes of abdominal and pelvic pain. The latest graphics and animations will give you new insights and understandings of this part of the body.

Lezing

Sobral

Onder welke omstandigheden beperken paramilitaire groepen hun gebruik van politiek geweld? Dit artikel onderzoekt het gebruik hiervan door de PIRA.

Ramesh Ganohariti onderzoekt de juridische identiteit in drie post-Sovjet aspirant-lidstaten en schetst in dit artikel vier veelvoorkomende scenario's.

Jaroslaw Kantorowicz and Rok Spruk onderzoeken de bijdrage van institutionele hervormingen aan economische groei.