Heart failure is a major health care problem with high mortality.

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

Leiden University’s Master of Law in European and International Human Rights Law (L.L.M.) looks at the various protection mechanisms applied to human rights across different political, social and cultural settings.

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

Promotor: Prof.dr. M. Danhof

Investigating epistemic and ethical practices in medical experimentation on humans in the colonial period in Southeast Asia.

Op 18 juni 2019 verdedigde Peter Kempees zijn proefschrift 'Hard power and the European Convention on Human Rights'. Het promotieonderzoek is begeleid door promotoren prof. dr. R.A. Lawson en prof. dr. H. Duffy.

Materials balances have been used in the recent past for the analysis of substance oriented environmental problems and the formulation of measures for environmental policy. In this study an integrated tool, based on the materials balance principle, has been developed for the analysis of both environmental…

Het onderzoek in dit proefschrift kijkt naar de rol van het locus ceuruleus - noradrenalinesysteem in verscheidene aspecten van menselijke cognitie, en de modulatie van de staat van het brein.

Promotor: E. F. van Dishoeck, Co-promotor: C. Walsh

What are the main factors associated with the stranding of the two seal species? What are the factors influencing the prevalence of disease in the two species? Which human-related factors influence the populations of the two seal species?

Human vocal communication and music perception represent advanced cognitive skills, seemingly innate and universal. These faculties encompass a range of perceptual and cognitive abilities. Cross-species research sheds light on the origins of musicality by investigating whether these traits are shared…

CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Eduard Fosch-Villaronga, universitair hoofddocent bij eLaw, heeft bijgedragen aan 'Cyber–Physical–Human Systems', een boek waarin de nieuwste ontwikkelingen in interacties tussen cyberfysische systemen en mensen worden onderzocht.

The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

Indo-European is the name of the language family to which English belongs, along with many sub-families such as Germanic languages and Romance languages. In this course, you will delve into the structure and origins of these branches, the oldest languages belonging to the language family, linguistic…

Wat zijn de effecten van digitalisering op de internationale rechtspraak?

Archeologe José Joordens reageert in het BNR radioprogramma Wetenschap Vandaag op de ontdekking dat onze oudste voorouders meer in bomen leefden dan gedacht.

Op 18 maart 2020 verdedigde Hoko Horii haar proefschrift 'Child Marriage as a Choice: Rethinking agency in international human rights'. Het promotieonderzoek is begeleid door promotoren prof.dr. A.W. Bedner en prof.dr. G.A. van Klinken (UvA).

Promotor: G.R. de Snoo, W. Kustiawan, Co-promotor: H.H. de Iongh

Jessica Vance Roitman en Wouter Veenendaal, onderzoekers aan het Koninklijk Instituut voor Taal-, Land- en Volkenkunde (KITLV)/Royal Netherlands Institute of Southeast Asian and Caribbean Studies, onderzoeken de oorsprong, ontwikkeling en consolidatie van politieke oligrachie op St. Maarten. Doorgaans…

Is onze muzikaliteit uniek? Dat wil het Bird Singalong-project uitzoeken. En daar hebben ze gevleugelde hulp bij nodig van over de hele wereld. ‘Door onderzoek naar hoe papegaaien liedjes leren, leren we ook meer over de oorsprong van onze eigen muzikaliteit.’ Heb jij een papegaai die kan meezingen…

Op 7 mei 2020 verdedigde Jolanda van der Vliet proefschrift 'The International Legal Protection of Environmental Refugees. A human rights-based, security and State responsibility approach'. Het promotieonderzoek is begeleid door promotoren prof.dr. N.J. Schrijver en prof.dr.ir. J.J.C. Voorhoeve.

A recent study on reintroduced tigers in Panna Tiger Reserve in India reveals that risks from tigers increased more because of human behaviour and people's livestock husbandry practices.

Freshwater and brackish water ecosystems are arguably the most vulnerable ecosystems on earth, due to concentrated human developments in and around them. The Pontocaspian (PC) region located at the border of Europe and Asia contains a variety of brackish water ecosystems and unique inhabitants, known…

Promotores: G.R. de Snoo, B. Sinsin, Co-Promotor: H.H. de Iongh

This report investigates the different approaches in the authorization process of GMOs for commercial use in the European Union and the United States of America. Three main aspects are considered and analyzed as potential causes of differences in the authorization process of GMOs for commercial use.…

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Sound is everywhere in the marine environment and hearing is therefore a very important for stimuli for fish. They use sound for orientation and communication, during migration, aggregation and spawning, but also for detection of prey and predators.

Promotie

Promotor: Prof.dr. J.P. Abrahams, Co-Promotor: N.S. Pannu

Leiden University College The Hague (LUC) biedt een 3-jarige bacheloropleiding aan waarin je je focust op Global Challenges; grote uitdagingen waar de mensheid mee te maken heeft: Vrede & Rechtvaardigheid, Diversiteit, Duurzaamheid en Welvaart. Je hebt ruimte om de opleiding zo in te richten als je…

Leiden University College The Hague (LUC) biedt een 3-jarige bacheloropleiding aan waarin je je focust op Global Challenges; grote uitdagingen waar de mensheid mee te maken heeft: Vrede & Rechtvaardigheid, Diversiteit, Duurzaamheid en Welvaart. Je hebt ruimte om de opleiding zo in te richten als je…

Promotor: C.J. ten Cate

In het NOS journaal op Radio 1 van dinsdag 6 februari spreekt Wil Roebroeks over de ontdekking van 171.000 jaar oude graafstokken. Het bestaan van dit gereedschap werd al langer vermoed, maar er waren nog niet eerder exemplaren van gevonden.

Britse en Australische onderzoekers hebben het tandsteen van een paar Spaanse Neanderthalers aan een DNA-analyse onderworpen en wat blijkt: de Neanderthaler eet groenten en bijna geen vlees.

Stellar feedback is a crucial ingredient in the evolution of galaxies.

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

Ethiopian wolves are endangered diurnal Afroalpine rodent hunters. I investigated the interaction between wolves, rodents and human land use in Borena Sayint National Park (BSNP), Abune Yosef and Aboi Gara in Ethiopia.

Promotor: M. Danhof, Co-promotor: E.C.M. de Lange

Lezing, Faculty Lecture

Leiden University College The Hague (LUC) biedt een 3-jarige bacheloropleiding aan waarin je je focust op Global Challenges; grote uitdagingen waar de mensheid mee te maken heeft: Vrede & Rechtvaardigheid, Diversiteit, Duurzaamheid en Welvaart. Je hebt ruimte om de opleiding zo in te richten als je…

Leiden University College The Hague (LUC) biedt een 3-jarige bacheloropleiding aan waarin je je focust op Global Challenges; grote uitdagingen waar de mensheid mee te maken heeft: Vrede & Rechtvaardigheid, Diversiteit, Duurzaamheid en Welvaart. Je hebt ruimte om de opleiding zo in te richten als je…

In dit artikel bespreken Joachim Koops en Christian Patz de uitgebreide beoordeling van de Duitse gereedheid op het gebied van 'Protection of Civilians' (PoC).

The origin and evolution of galaxies are closely linked to many different physical phenomena.

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

Can we provide the Dutch government with an integrative framework, wherein the various policies can be placed and the need for further measures can be identified?