The logic seems inescapable indeed. The bigger the population, the higher the probability it contains an Einstein. Hence, bigger populations are more likely to develop complex culture.

In this work, we attempt to answer the question:

Promotor: P.D. Grünwald

This thesis applies data mining in commercial settings in the telecommunications industry.

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

This thesis describes the importance of being able to control the selectivity of potential drug candidates.

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

With the help of quantum mechanics, digital quantum hardware may be able to tackle some of the problems that are too difficult for ordinary computers. But despite these expectations and the ongoing effort of the research community, reliable quantum computers are not yet realized in a lab setting.

Promotor: G.P. van Wezel

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Promotor: Prof.dr. M. de Jong

Van Galileo Galilei tot Albert Einstein, van Anna Maria van Schurman tot Anton de Kom: het is slechts een greep uit 25 auteurs die met hun boeken en ideeën een buitengewone invloed hebben gehad op de wereld, soms zelf tot nu. De Universitaire Bibliotheken Leiden en het Rijksmuseum van Oudheden organiseren…

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

The basic program comprises a total of twelve courses organized by the Research School, that have been purpose-developed for training and support of PhD students and Research MA students who specialize in Medieval Studies (history, art history, and literary history, in particular).

This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.

In populations with a seed-bank, individuals can temporarily become dormant and refrain from reproduction until they can become active again. The repository of all dormant individuals in the population is called the seed-bank. Seed-banks are observed in many taxa, including plants, bacteria and other…

Promotoren: R. Tijdeman, A.K. Lenstra, Co-promotor: H.J.J. te Riele

Natural vanilla flavor is one of the most important in the world. However, the cost of this flavor is expensive. Production of this flavor by alternative methods, could reduce the cost.

In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.

The main focus of the thesis is the discovery and development of novel inhibitors of bacterial metallo-β-lactamases (MBLs).

Promotores: A.H. Meijer, H.P. Spaink

De onstuitbare opmars van de N.V. Zuid-Korea

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

How the global distribution of vegetation stands dominated by arbuscular and ectomycorrhizal plants relate to principle aspects of belowground carbon accumulation processes?

Ineke Sluiter, hoogleraar Griekse taal en literatuur, was als voorzitter van de KNAW de keynote speaker van de Diversiteit & Inclusiviteit week aan de TU Delft. Het journalistieke platform Delta van de universiteit interviewde haar over cancel culture en woke zijn.

Eén van de gehonoreerde projecten is Bridging art, design and technology through Critical Making van onze hoogleraar Prof. dr. Janneke Wesseling en dr. Florian Cramer (Willem de Kooning Academy).

Het was weer gezellig druk in het Rijksmuseum van Oudenheden! Op 22 juni is de zomertentoonstelling ‘Books that made History’ van Universitaire Bibliotheken Leiden (UBL) en het Rijksmuseum van Oudheden (RMO) geopend. In de tentoonstelling zijn 25 Leidse boeken uit de collecties van de UBL te zien die…

Students Practicing Citizen Journalism

Promotor: B.van de Water, Co-promotor: L.S.Price

In close collaboration with the Center for Medieval Studies (Fordham), Centre for Medieval literature (Odense and York) and Centre for Medieval Studies (York), the University of Ghent organizes an Autumn School for PhD- and MA-students in Medieval Studies (18-22 October 2021). It will be organized in…

Announcement of a new publication by Janneke Verheijen, lecturer at the Institute of Cultural Anthropology and Development Sociology.

Do e-waste workers display enhanced effects of adverse health effects due to informal e-waste processing in Nigeria? Is there a difference between the health outcomes of the exposed and the control groups? Are there difference in health effects within and between job groups (collectors, dismantlers,…

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

Leiden University and the Ministry of Infrastructure and Water Management are involved in a collaboration in the form of a research project titled 'Data-Driven Risk Assessment in Infrastructure Networks'

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

Promotor: F.S. de Boer, Co-promotor: M.M. Bonsangue

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

GLOBOX is a spatially differentiated multimedia fate, exposure and effect model. It is used for the calculation of spatially differentiated LCA characterisation factors on a global scale.

Promotor: Prof.dr. G.P. van Wezel

The Economics and Governance specialisation of the Master in Public Administration teaches you to formulate problem-solving approaches to concrete policy issues found at the intersection between economics and public administration. This specialisation is a unique joint offering of the Department of…

How should jurisdictions, both on the national and on the supra-national level, handle the interaction between public and private law where it regards the regulation of financial markets?

In June 2024, the University of Groningen organizes a summer school, titled "Things that Matter". The Summer School explores challenges in digitizing source materials, questioning distinctions between physical and digital copies. It delves into the impact of virtual collections and criteria for digitization,…

In de serie tafelgesprekken ‘Van kluis naar kussen’ krijgt de kijker een blik achter de schermen van de Bijzondere Collecties. In deze speciale uitzending staat de zomertentoonstelling 'Books that made History' van de Universitaire Bibliotheken Leiden en het Rijksmuseum van Oudheden centraal. In de…

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

Development of an aggregated impact indicator to measure decoupling.