In this work, we attempt to answer the question:

Promotor: P.D. Grünwald

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

This thesis applies data mining in commercial settings in the telecommunications industry.

Fokelien Kootstra verdedigde haar proefschrift op 23 april 2019

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

This thesis describes the importance of being able to control the selectivity of potential drug candidates.

In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.

Promotor: Prof.dr. M. de Jong

Promotor: G.P. van Wezel

Promotores: A.H. Meijer, H.P. Spaink

In populations with a seed-bank, individuals can temporarily become dormant and refrain from reproduction until they can become active again. The repository of all dormant individuals in the population is called the seed-bank. Seed-banks are observed in many taxa, including plants, bacteria and other…

Promotoren: R. Tijdeman, A.K. Lenstra, Co-promotor: H.J.J. te Riele

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

Natural vanilla flavor is one of the most important in the world. However, the cost of this flavor is expensive. Production of this flavor by alternative methods, could reduce the cost.

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

The basic program comprises a total of twelve courses organized by the Research School, that have been purpose-developed for training and support of PhD students and Research MA students who specialize in Medieval Studies (history, art history, and literary history, in particular).

Academici hebben op het gebied van inlichtingen geworsteld met de vraag onder welke voorwaarden internationale samenwerking op het gebied van inlichtingen plaatsvindt. De meeste richten zich op transactionele motieven en gegarandeerde opbrengsten, de zogenaamde ‘Quid pro Quo’. Tegelijkertijd wordt vertrouwen…

The main focus of the thesis is the discovery and development of novel inhibitors of bacterial metallo-β-lactamases (MBLs).

Announcement of a new publication by Janneke Verheijen, lecturer at the Institute of Cultural Anthropology and Development Sociology.

Drug development critically depends on preclinical models that mimic human physiology, yet traditional two-dimensional cultures and animal models often lack predictive power.

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.

For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

With the help of quantum mechanics, digital quantum hardware may be able to tackle some of the problems that are too difficult for ordinary computers. But despite these expectations and the ongoing effort of the research community, reliable quantum computers are not yet realized in a lab setting.

De onstuitbare opmars van de N.V. Zuid-Korea

This proposed research uses ego-documents from visual artists that were not intended for publication to reassess the scholarly debate on the demise of the Russian Avant-garde aesthetic in the twenties and early thirties of the 20th century.

Promotor: Prof.dr. G.P. van Wezel

Students Practicing Citizen Journalism

Eén van de gehonoreerde projecten is Bridging art, design and technology through Critical Making van onze hoogleraar Prof. dr. Janneke Wesseling en dr. Florian Cramer (Willem de Kooning Academy).

Promotor: B.van de Water, Co-promotor: L.S.Price

The research in this dissertation aims to optimise blood donation processes in the framework of the Dutch national blood bank Sanquin. The primary health risk for blood donors is iron deficiency, which is evaluated based on donors' hemoglobin and ferritin levels.

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Promotor: F.S. de Boer, Co-promotor: M.M. Bonsangue

In close collaboration with the Center for Medieval Studies (Fordham), Centre for Medieval literature (Odense and York) and Centre for Medieval Studies (York), the University of Ghent organizes an Autumn School for PhD- and MA-students in Medieval Studies (18-22 October 2021). It will be organized in…

GLOBOX is a spatially differentiated multimedia fate, exposure and effect model. It is used for the calculation of spatially differentiated LCA characterisation factors on a global scale.

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

The Economics and Governance specialisation of the Master in Public Administration teaches you to formulate problem-solving approaches to concrete policy issues found at the intersection between economics and public administration. This specialisation is a unique joint offering of the Department of…

How should jurisdictions, both on the national and on the supra-national level, handle the interaction between public and private law where it regards the regulation of financial markets?

In June 2024, the University of Groningen organizes a summer school, titled "Things that Matter". The Summer School explores challenges in digitizing source materials, questioning distinctions between physical and digital copies. It delves into the impact of virtual collections and criteria for digitization,…

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Women Writing Mexico (WWM) is a network of women and men concerned with the human rights crisis in Mexico and more specifically, with the impact of structural forms of poverty, everyday violence, and discrimination based on gender, race, social class, and ethnicity, that particularly have an impact…

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

Promotores: Prof.dr. J.N. Kok, Prof.dr. C.A. Mandemakers, Co-Promotor: G. Bloothooft

Urbanisation is steadily increasing with estimates expecting that 68% of the global population will live in cities by 2050. To accommodate the rural to urban transition, large quantities of land are transformed from natural to urban lands.