Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

Understanding how galaxies form, interact, and evolve comes largely from comparing theory predictions with observational data. Numerical simulations of galaxies provide the most accurate approach to testing the theory, as they follow the non-linear evolution of gas and dark matter in great detail and…

Bacteria have the ability to alter their morphology in order to adapt to changing environments.

In astronomy, the interpration of observations and measurements plays a crucial role: we rely purely and fundamentally on the information that reaches us as observers. And 80% of all matter in the universe is undetectable directly.

Promotor: P.D. Grünwald

The rapidly increasing commercial application of metallic nanoparticles within products will inevitably enhance the amount of NPs being released into soil.

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

Promotor: E. Gittenberger, Co-promotores: B.W. Hoeksema; L.P. van Ofwegen

When observing star-forming galaxies, we are not only seeing stellar light, but we also see how this interacts with galactic gas and dust. This thesis contains studies of the stellar, nebular and dust properties of low mass star-forming galaxies.

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

Dr. Ir. Ionica Smeets, onder meer bekend als lid van het duo ‘De Wiskundemeisjes’, is per 1 juli aangesteld als deeltijd hoogleraar Science Communication aan de Universiteit Leiden. De komende vijf jaar zal zij onderzoek doen naar wetenschapscommunicatie, studenten doceren over het vak en hen enthousiasmeren…

In multi/many-core System-on-Chips (SoCs), the performance is almost linearly scaling with the number of processing elements.

Promotor: Prof.dr. K.H. Kuijken, Co-Promotor: H.Hoekstra

Tin electrodeposition applications have rapidly evolved in the past 25 years.

Novel entities may pose risks to humans and the environment. The small particle size and relatively large surface area of micro- and nanoparticles (MNPs) make them capable of adsorbing other novel entities, leading to the formation of aggregated contamination.

By growing in a soil plants change the biotic and abiotic properties of the soil in which they grow.

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.

This thesis aims to investigate the effect of tripartite interaction between microbial inoculants, the plant, and herbivore insects on the rhizosphere microbiome and volatilome. We investigated the rhizosphere microbiome and volatilome of tomato plants exposed to insect herbivory and/or inoculated with…

This interdisciplinary study focuses on (trans)national ethnic and popular networks, combining historical-ethnographic and computational methods to understand the ‘workings’ of networked conflict interfering in the increasingly violent conflict in the Sahel (Africa) and beyond. The project focuses on…

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

Freshwater and brackish water ecosystems are arguably the most vulnerable ecosystems on earth, due to concentrated human developments in and around them. The Pontocaspian (PC) region located at the border of Europe and Asia contains a variety of brackish water ecosystems and unique inhabitants, known…

Promotor: E. Bouwman, Co-promotor: S. Bonnet

I have studied the hot, diffuse gas around and between galaxies. Specifically, I have used the EAGLE numerical simulations of galaxy formation to predict the properties of this gas, and I have used those properties to predict specific observables: soft X-ray absorption and emission lines.

In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.

To contribute to the body of knowledge aiming at a better coverage of ecosystem service assessment in LCA studies, this thesis dives into the challenges of incorporating existing ecosystem service methods within the impact assessment phase of the conventional LCA framework.

Promotor: E.F. Smets Co-promotor: J. Geml

The main object of study in this thesis is an Arakelov inequalitywhich bounds the degree of an invertible subsheaf of the direct image ofthe pluricanonical relative sheaf of a semistable family of curves.

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

Promotor: G.R. de Snoo, Co-promotor: C.J.M. Muster

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

In this thesis, we have studied cell images from two types of cells, including pollen grains and the immune cells, neutrophils. These images are captured using a bright field microscope and a confocal microscope.

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

De League of European Research Universities (LERU) doet aanbevelingen voor de toekomst van het Social Science en Humanities Research (SSH) in Europa. Dit onderzoek is van vitaal belang voor het opbouwen van een innovatief en veerkrachtig Europa.

Het is een warme dag. De zon brandt fel terwijl bioloog Marco Roos zich in het struikgewas richting een bijzonder plantje begeeft. Insecten zoemen, vogels tsjirpen. Op de achtergrond verrijst het LUMC: op het Bio Science Park komen mens en natuur op een bijzondere manier samen.

The class-imbalance problem is a challenging classification task and is frequently encountered in real-world applications. Various techniques have been developed to improve the imbalanced classification performance theoretically and practically.

The thesis mainly contributes to the characterization of Majorana fermions as they appear in the Condensed Matter context.

The thesis describes experimental steps towards reduction of friction on the macroscopic scale by scenarios of thermo- and superlubricity well-known on the nanoscale.

How can mega sand nourishments, such as the Sand Motor, be designed and managed for optimal ecosystem services provision ?

In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

Promotores: P. Stevenhagen, E. Fouvry (Univeriste Paris Saclay)

Prof.dr. J. Memelink

Arithmetic geometry concerns the number-theoretic properties of geometric objects defined by polynomials. Mathematicians are interested in the rational solutions to these geometric objects.

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.