The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

The findings in this thesis improve the understanding of 1) the relationship between exposure characteristics and toxicity of ENPs, 2) the joint toxic action of ENP mixtures and the comparison to metal salt mixtures, 3) how NOM affects the individual and joint toxicity of ENPs, 4) the extent of trophic…

Remus Dame

Enforcement of group cooperation fails because of discriminatory punishment, according to research by Welmer Molenmaker and colleagues. When group members have different backgrounds, punishment turns into a double-edged sword: no longer used just to prevent group exploitation, but also to break the…

De centrale vraag is wat Nederland kan leren van de wijze waarop deze landen de rechtshandhaving en de rechtstaat in hun overzeese gebieden hebben ingericht.

Cognitive enhancement is het gebruik van elke methode of techniek met als doel het verbeteren van cognitieve prestaties.

Met het SAPPAO-project willen we de voorspelling van geplande vluchten nauwkeuriger en betrouwbaarder maken. De volledige naam van het project is ‘A Systems Approach towards Data Mining and Prediction in Airlines Operations’.

Promotie

Promotie

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf

The use of N fertilizers has increased worldwide in the past century. While this increased input of N has increased food productivity, it has also contributed to decreases in biodiversity, soil quality and environmental health, including increases in greenhouse gas emissions.

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

Sustainable energy from wind and solar is most readily available near the sea.

For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

Promotores: G.R. de Snoo, W.T. de Groot, Co-promotor: C.J.M. Musters

Innovation plays an essential role in firms' competitiveness and long-term success. It varies from different types, ranging from run-of-the-mill innovation that brings incremental changes to existing technologies to radical innovation that breaks from existing trajectories.

Developing robust algorithms and theory for establishing cause-effect relationships from observational data that scale up to large data sets

LCA has become an important method to study environmental impacts of human activities. Still, there are several methodological issues in LCA that can adversely affect the results reliability.

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.

In this thesis we push the boundaries of high-resolution imaging at radio frequencies between 100 and 200 MHz. Using the International LOFAR Telescope that spans across Europe we achieve sub-arcsecond angular resolution.

Bij Cambridge University Press (CUP) verscheen onlangs van Ingrid Leijten het boek Core Socio-Economic Rights and the European Court of Human Rights. Het boek maakt onderdeel uit van de serie Cambridge Studies in European Law and Policy en heeft als onderwerp de bescherming van sociaaleconomische rechten…

This thesis aims to address offshore wind energy (OWE)-related environmental impacts.

Timo Slootweg, associate professor at he department Philosophy of Law, published a chapter about Paul Scholten in

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

Promotor: Prof.dr. J.W.M. Frenken

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik

In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).

A dense region of a gaseous and dusty cloud collapses to form a protostar surrounded by a disk and an envelope. This thesis uses both observations and models to study physical and chemical conditions of these protostellar systems which are likely where planets start to form.

Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)

The experiences of ethnic ‘Other’ females have – until recently – been widely overlooked in the study of sport. There continues to be a need to produce critical scholarship about ethnic 'Other' girls and women in sport and physical culture, in order to represent their complex, multifarious and dynamic…

The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

Promotor: Prof.dr. C.U. Keller

With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…

Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.

Forgotten Lineages explores the paths through which generations of formally enslaved and their descendants gradually forgot their past of enslavement under Dutch and British imperial rule and became local subjects in Sri Lanka and South Africa. It explores why and how forgetting rather than memory became…

A convolutional neural network (CNN) is a biologically inspired algorithm, highly capable at processing images and videos.

Promotor: G.R. de Snoo Co-promotor: C.J.M. Musters

Chapter 1,contains the numerical verification of the Birch and Swinnerton-Dyer conjecture for hundreds of Jacobians of hyperelliptic curves of genus 2, 3, 4 and 5.

The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.

Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri

Promotor: C.J. ten Cate

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

Ieder jaar brengt een fotograaf Leiden in beeld als Stadsfotograaf van het Leidsch Dagblad. Dit jaar is het de eer aan Leonie van der Helm, alumna van culturele antropologie. De komende 52 weken brengt Van der Helm de betekenis van ‘thuis’ in beeld.

Promotie

Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)