Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

Promotor: Prof.dr. S. Haring

This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

Machine Learning is becoming a more and more substantial technology for industry.

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.

Promotor: Prof.dr. J.W.M. Frenken

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich

Leiden University and the Ministry of Infrastructure and Water Management are involved in a collaboration in the form of a research project titled 'Data-Driven Risk Assessment in Infrastructure Networks'

The energy system is at the heart of two of the greatest challenges of the 21st century: decreasing CO2 emissions to meet the ambitions of the Paris agreement while fulfilling the growing energy demand associated with the economic aspirations of a growing world population.

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

Promotor: Prof.dr. E. Bouwman, Co-Promotor: S. Bonnet

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Promotor: F.S. de Boer, Co-promotor: M.M. Bonsangue

Possible improvements for the assessment of abiotic depletion in LCA.

It is an established fact that the Standard Model has to be extended to explain the so-called Beyond the Standard Model (BSM) phenomena: dark matter, matter-antimatter asymmetry of the Universe and neutrino flavour oscillations.

Promotor: Prof.dr. R.M.H. Merks

For centuries astronomers studied the Universe by collecting light. Nowadays, we are living in times of great technological advancements, which allow us to explore our Universe in a new way - though gravitational wave radiation.

Mechanical metamaterials are man-made materials which derive their unusual properties from their structure rather than their composition.

The project Multimedia Research and Documentation of African Oral Genres: Connecting Diasporas and Local Audiences (Director: D.Merolla) focuses on multimedia as technology that allows scholars to share documentation and scientific knowledge with the cultural owners of the collected oral genres.

Waar eindigt de mens en begint de machine? Wat worden we wijzer van robots? Hoe weet je of een filmpje op internet echt is of nep? Over die vragen gaat het op het congres Brave New World op 8 en 9 november.

Where does the urge to collect come from? What are the explicit or underlying reasons for gathering large amount of objects?

Social media spelen een sleutelrol bij het oproepen tot verzet tegen coronamaatregelen. Online worden afspraken gemaakt over waar en wanneer mensen zich gaan verzamelen. De autoriteiten hebben niet altijd goed zicht op wat er gebeurt en mogen ook niet zomaar infiltreren, terwijl burgers vaak wel eenvoudig…

Simone van der Hof, hoogleraar Recht en Digitale Technologie, sprak met NRC over haar perspectief op Instagram Teens. Ze heeft twijfels over de leeftijdsrestrictie en de parental supervision-functie.

Jet Bussemaker, hoogleraar Wetenschap, beleid en maatschappelijke impact in de zorg, schrijft over het herstellen van collectief leren in de praktijk

Op 27 november 2019 promoveerde David de Boer met zijn proefschrift Religious Persecution and Transnational Compassion in the Dutch Vernacular Press 1655-1745. Voor zijn onderzoek analyseerde hij een paar honderd pamfletten, kranten en tijdschriften die voornamelijk werden gepubliceerd in de zeventiende-eeuwse…

Promotores: Prof.dr. A.G.G.M. Tielens, Prof.dr. L.B.F.M. Waters (UvA), Prof.dr. C. Dominik (UvA)

The class-imbalance problem is a challenging classification task and is frequently encountered in real-world applications. Various techniques have been developed to improve the imbalanced classification performance theoretically and practically.

The first direct detection of gravitational waves opened the possibility of mapping the Universe via this new and independent messenger.

Promotor: Prof.dr. C.U. Keller, Co-promotor: Frans Snik

We analyse the link between media consumption and the attitudes toward people living with HIV/AIDS in Chile. We used data from a sample of 1000 people, obtained in the 2011 wave of the World Values Survey (WVS). We use a logistic binary regression model by maximum likelihood. Our results suggest that…

M.T.M. Koper, Co-promotor: D.G.H. Hetterscheid

Single-Molecule Microscopy (SMM) techniques constitute a group of powerful imaging tools that enable researchers to study the dynamic behavior of individual molecules.

Promotor: J.W.M. Frenken Co-Promotor: R. Felici

Promotor: F. Arbab, R. De Nicola, Co-Promotor: M. Tribastone

Universitair docenten spelen een belangrijke rol bij het opwekken van interesse voor onderzoek bij hun studenten. In dit onderzoek worden de opvattingen van Chinese en Nederlandse docenten over de rol van onderzoek in het onderwijs bekeken. Hoe kunnen deze opvattingen worden verklaard vanuit de culturele…

Promotor: T. Hankemeier, Co-promotor: R.J. Vreeken

How are new drugs developed? This question is central to the Minor Modern Drug Discovery (MDD), which covers the entire trajectory from disease to drug molecule and vice versa. The various research groups involved offer a complementary and interdisciplinary perspective by connecting the diverse subjects…

De Leiden Teachers’ Academy organiseert jaarlijks een symposium over onderwijsvernieuwing aan de Universiteit Leiden.

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