In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Promotors: Prof.dr. P.J. Punt, Prof.dr. C.A.M.J.J. van den Hondel

Leiden University and the Ministry of Infrastructure and Water Management are involved in a collaboration in the form of a research project titled 'Data-Driven Risk Assessment in Infrastructure Networks'

Material outflows from industrial economies.

Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

Ethiopian wolves are endangered diurnal Afroalpine rodent hunters. I investigated the interaction between wolves, rodents and human land use in Borena Sayint National Park (BSNP), Abune Yosef and Aboi Gara in Ethiopia.

Development of GHG calculator for bio-electricity and heat.

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

This monograph focuses on clustering of objects in high-dimensional data, given the restriction that the objects do not cluster on all the attributes, not even on a single subset of attributes, but often on different subsets of attributes in the data.

Op 11 november 2021 verdedigde Mariana Gkliati het proefschrift 'Systemic Accountability of the European Border and Coast Guard'. Het promotieonderzoek is begeleid door promotoren prof.dr. P. Rodrigues en prof.dr. L. Besselink (UvA).

One of the key limitations of the direct imaging of exoplanets at small angular separations are quasi-static speckles that originate from evolving non-common path aberrations (NCPA) to which the primary adaptive optics system is inherently blind. The main focus of this thesis is the development and…

Artificial intelligence algorithms govern in subtle, yet fundamental ways, the way we live and are transforming our societies. The promise of efficient, low‐cost or ‘neutral’ solutions harnessing the potential of big data has led public bodies to adopt algorithmic systems in the provision of public…

This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.

Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

Interactive exploration of large volumes of data is increasingly common, as data scientists attempt to extract interesting information from large opaque data sets. This scenario presents a difficult challenge for traditional database systems, as (1) nothing is known about the query workload in advance,…

In populations with a seed-bank, individuals can temporarily become dormant and refrain from reproduction until they can become active again. The repository of all dormant individuals in the population is called the seed-bank. Seed-banks are observed in many taxa, including plants, bacteria and other…

1. To what extent do metallic NPs added to soil extractions change the activity, abundance, or community composition of microbes? 2. How do the effects of metallic NPs on soil microbes differ from the effects of the ions shedding from corresponding NPs?

Promotor: Prof.dr. J.P. Abrahams, Co-Promotor: N.S. Pannu

Promotor: Prof.dr. T. Schmidt, Co-Promotor: S.J.T. van Noort

Promotor: Prof.dr. M.A.G.J. Orrit

To gain more insight into the evolutionary development of orchid flowers and fruits, the orchid species Erycina pusilla was studied. The evolutionary origin of the median petaloid sepal, the callus on the labellum, and the stelidia was studied.

Forgotten Lineages explores the paths through which generations of formally enslaved and their descendants gradually forgot their past of enslavement under Dutch and British imperial rule and became local subjects in Sri Lanka and South Africa. It explores why and how forgetting rather than memory became…

Tracing the evolution of the molecular gas content in galaxies is critical for a complete understanding of galaxy formation and evolution, as it provides the direct fuel for star formation. Studies of high-redshift (z>1) molecular gas reservoirs, most commonly traced by carbon monoxide (CO), have seen…

Career Event

Het Zuid-Koreaanse kijkcijferkanon Squid Game is hard op weg om de meest succesvolle Netflix-productie ooit te worden. In meer dan negentig landen staat de serie op de eerste positie in de kijkcijferlijst. Hoogleraar Koreastudies Remco Breuker ziet duidelijk hoe Zuid-Koreaanse popcultuur steeds populairder…

Promotie

Wetlands provide many ecosystem goods and services which include fish production. The sustainability of small-scale fisheries (SSF) has received considerable attention in recent years because fish is one of the major sources of animal protein to a considerable fraction of the global population which…

Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)

Wiskunde en Natuurwetenschappen, Centrum voor Milieuwetenschappen Leiden (CML)

Dit onderzoek richt zich op een historisch-sociale analyse van een geselecteerd corpus van romans uit de moderne Turkse literatuur die het thema delen van de migratie van Anatolische steden en dorpen naar Istanbul en de strijd van immigranten in deze stad tegen verschillende uitsluitingsmechanismen.

Op 30 oktober 2019 verdedigde Paul Jager zijn proefschrift 'De concern(genoten)enquête'. Het promotieonderzoek is begeleid door promotoren prof.mr. S.M. Bartman en prof.mr. M.E. Koppenol-Laforce.

This article studies the influence of framing on preferences for cooperation with the EU.

Je kunt met elk vwo-profiel instromen in de bacheloropleiding Pedagogische Wetenschappen. Wel is een goede kennis van het Engels belangrijk, aangezien een deel van de literatuur Engelstalig is.

De master Literary Studies van de Universiteit Leiden biedt een gespecialiseerde kwalificatie in één van vier talen (Engels, Frans, Duits en Italiaans) en culturen, of een vergelijkend perspectief op literatuur en cultuur. Elk programma biedt veel ruimte voor individuele keuzes.

Levende Talen en het Expertisecentrum mvt hebben in 2009 de Gerard Westhoff-Taaldidactiekprijs ingesteld voor de beste scriptie op het gebied van vreemdetalendidactiek (in brede zin, inclusief de didactiek van literatuur en cultuur), geschreven door studenten aan Nederlandse lerarenopleidingen.

Vrouwen ontbreken vaak in historische canons, waardoor het lijkt alsof ze nauwelijks impact op de geschiedenis hebben gehad. Universitair hoofddocent Engelse literatuur Nadine Akkerman vertelt bij de podcast 'Dr. Kelder en Co' meer over haar onderzoek naar Elizabeth Stuart, Koningin van Bohemen.

Onderstaand een overzicht van alle vakken die door de afdeling Economie worden verzorgd.

En dan ben je afgestudeerd neerlandicus. Je beheerst het Nederlands uitstekend, zowel mondeling als schriftelijk. Bovendien ben je een onafhankelijke, kritische en creatieve denker die complexe zaken snel en adequaat kan analyseren. Dat maakt je geschikt voor veel verschillende functies.

Dit project wordt gefinancierd met een beurs van het European Research Council (ERC) in het kader van het EU-onderzoeks- en innovatieprogramma Horizon 2020, onder nummer 101054849 (PURANA).

De Franse taal associeer je misschien meteen met Frankrijk, met bleu-blanc-rouge, stokbrood en de Eiffeltoren. Maar het Frans is een echte wereldtaal die tot ver buiten de grenzen van Frankrijk wordt gesproken: in grote delen van Afrika, Canada en op de Caraïben.

This thesis has shed light on some of the ways in which the local electrolyte composition can differ from the bulk and how these changes in the local reaction environment can determine the activity and/or selectivity of two important electrocatalytic reactions, namely, electrochemical CO2 reduction…

Gamic Learning in East Asian Studies - Wat kunnen spellen ons vertellen over de manier waarop mensen leren?

In this thesis, we study travelling waves in stochastic reaction-diffusion equations. We extend techniques from the deterministic theory for travelling waves to apply to the stochastic version, which allows us to compute the stochastic wave speed and shape, and draw conclusions on the stability of the…

The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.