1,524 zoekresultaten voor “taken development” in de Publieke website
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Activity-based protein profiling in drug discovery
In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.
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Student projects
To get an idea of the science communication products and research that is possible, a few examples of student projects of recent years are shown below.
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Medewerkers
MCS bestaat uit vijf medewerkers, die allen sterke banden hebben met de ‘museums and collections’ opleiding bij de faculteit geesteswetenschappen en ‘heritage and museums’ bij de faculteit archeologie.
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Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: M. Danhof, Co-promotor: E.C.M. de Lange
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Onderwijs
BSc-programma’s: ‘Political Science’, ‘International Relations and Organisations’. MSc-opleiding: Political Science, met specialisaties ‘International Organisation’; ‘Dutch Politics; ‘Nationalism, Ethnic Conflict, and Development’; ‘International Politics’; ‘Political Legitimacy and Justice’; ‘Democracy…
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Libya Since the 2011 Revolution: Troubles, Causes, and Future
Professor Dirk Vandewalle is een internationaal veelgevraagde en gerenommeerde Libië-expert. In deze lezing gaat hij in op twee essentiële vragen over de huidige situatie in Libië. Hoe komt het dat het Libische politieke systeem zo fragiel geworden is? En hoeveel hoop is er nog dat Libië als eenheid…
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Data-Driven Risk Assessment in Infrastructure Networks
Leiden University and the Ministry of Infrastructure and Water Management are involved in a collaboration in the form of a research project titled 'Data-Driven Risk Assessment in Infrastructure Networks'
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Electrocatalytic CO2 reduction toward liquid fuels : on heterogeneous electrocatalysts and heterogenized molecular catalysts
With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.
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Allosteric modulation by sodium ions and amilorides of G protein-coupled receptors
Promotor: A.P. IJzerman
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Lipids as therapeutic targets for barrier repair in skin diseases
The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.
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How to scale clearance from adults to children for drugs undergoing hepatic metabolism?
The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.
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The use of computational toxicology in hazard assessment of engineered nanomaterials
Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…
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Evolutionary adaptability of β-lactamase: a study of inhibitor susceptibility in various model systems
β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…
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Synthetic Methodology Towards ADP-Ribosylation Related Molecular Tools
Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.
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Transborder Governance of Forests, Rivers and Seas
Natural resources often stretch across borders that separate modern nation states. This can create conflict and limit opportunities for regulated consumption of their goods and services, but also provide opportunities for joint multinational efforts that exceed single country capabilities.
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Thrips resistance in Gladiolus: an eco-metabolomic approach
Breeding for resistance becomes more and more important because we want to reduce the use of pesticides. A fast and cheap alternative can be to make use of morphological or chemical markers.
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Social Dimensions of Crane and Wetland Conservation in African Rural Landscapes: Insights from Kenya, Uganda and Zimbabwe
This thesis focuses on the social dimensions of crane and wetland conservation in rural landscapes in Kenya, Uganda and Zimbabwe.
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Allosteric modulation by sodium ions and amilorides of G protein- coupled receptors
Promotor: A.P. IJzerman
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Novel factors modulating AGC kinase signaling-controlled polar auxin transport
The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.
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Arabidopsis AGC3 kinases and PIN plasma membrane abundance
The plant hormone auxin plays a central role in the growth and development of plants. Auxin acts in a concentration dependent manner and polar cell-to-cell transport of this hormone determines its distribution in the tissues of plants. This polar auxin transport is mediated by several families of auxin…
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Aquatic eDNA: Beyond Species Presence
As a non-invasive genetic method, eDNA based approaches have become an important component of ecologists' and environmental managers' toolkits for biomonitoring in conservation and an increasingly important source of ecological knowledge.
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Effect of Nanoparticles on Microbial Catabolism and Community Structure using Biolog techniques
1. To what extent do metallic NPs added to soil extractions change the activity, abundance, or community composition of microbes? 2. How do the effects of metallic NPs on soil microbes differ from the effects of the ions shedding from corresponding NPs?
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Biodiesel production using blue-green cyanobacterium Synechococcus elongatus PCC 7942
Promotores: Prof.dr. C.A.M.J.J. van den Hondel, Prof.dr. V. Meyer (Technische Universität Berlin)
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Europa Instituut
Het Europa Instituut van de Universiteit Leiden is één van de oudste academische instellingen gespecialiseerd in het recht van de Europese Unie en het Europees Verdrag inzake de Rechten van de Mens. Het werd opgericht in 1957, hetzelfde jaar als de Europese Economische Gemeenschap zelf.
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A novel formulation for skin barrier repair : from ex vivo assessment towards clinical studies
The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.
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Optimisation of first clinical studies in special populations: towards semi-physiological pharmacokinetic models
M. Danhof, Co-promotores: J. Freijer, A. Yassen
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Voorlichtingsactiviteiten
Kom naar onze online en oncampus events om ons beter te leren kennen!
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Mathematisch Instituut
Het Mathematisch Instituut is verantwoordelijk voor het onderzoek en onderwijs in de wiskunde en de statistiek aan de Universiteit Leiden.
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Voltooid onderzoek
Hieronder leest u welke onderzoeken wij in het verleden hebben uitgevoerd.
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Metals in LCIA
A critical look at the impact assessment modelling of metals in Life Cycle Impact Assessment and improvement options.
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Waarom Universiteit Leiden?
Aan de Academische Pabo ontwikkel je je tot een vakkundige leerkracht met wetenschappelijke kennis van kinderen, opvoeding en onderwijs.
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Groepsgedrag: one for the team
Leidse wetenschappers onderzoeken groepsgedrag. Ze ontdekten onder meer dat mensen zich waarschijnlijk instinctmatig opofferen voor een mede-groepslid. Met dit soort inzichten kunnen we sociale processen in een wijk of binnen een bedrijf beter begrijpen en beïnvloeden.
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Belastingbudget
Op 4 maart 2021 verdedigde Michiel Spanjers zijn proefschrift 'Belastingbudget'. Het promotieonderzoek is begeleid door promotoren prof.dr. J.P. Boer en prof.dr. H. Vording.
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Magnetic resonance force microscopy for condensed matter
In this thesis, we show how MRFM can usefully contribute to the field of condensed-matter.
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Beslissen in grensgebieden
Een onderzoek naar het Mobiel Toezicht Veiligheid zoals uitgevoerd door de Koninklijke Marechaussee
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Kearifan Kesehatan Lokal: indigenous medical knowledge and practice for integrated nursing of the elderly with cardiovascular disease in Sumedang
The different kinds of cultural perspectives on health and disease of the participants are related to their knowledge, beliefs, values and practices manifested in various forms of lifestyle in Indonesia. The cultural diversity of the population is also related to differences in health behaviour.
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Arithmetic of affine del Pezzo surfaces
In this thesis integral points on affine del Pezzo surfaces are studied.
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Linking simple molecules to grain evolution across planet-forming disks
Planets are formed in disks of gas and dust around young stars.
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Coiled-coils on lipid membranes: a new perspective on membrane fusion
Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros
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Credible sets in nonparametric regression
Promotor: Prof.dr. A.W. van der Vaart
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Next generation bacitracin: reimagining a classic antibiotic
Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…
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Optimizing antifungal treatment through pharmacometrics: dosing considerations to enhance outcome
Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.
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How lawyers win land conflicts for corporations: Legal Strategy and its influence on the Rule of Law in Indonesia
Op 23 juni 2020 verdedigde Santy Kouwagam haar proefschrift 'How lawyers win land conflicts for corporations: Legal Strategy and its influence on the Rule of Law in Indonesia'. Het promotieonderzoek is begeleid door promotoren prof.dr. A.W. Bedner en prof.dr. C.E. von Benda-Beckmann.
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Multivariate Humanities
Dit op casestudies gebaseerde Engelstalige boek over multivariate analyse voor gevorderde studenten in de geesteswetenschappen legt de nadruk op beschrijvende, exploratieve analyses van verschillende soorten datasets uit een breed scala van subdisciplines, waarbij het gebruik van multivariate analyse…
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Duurzame conflictoplossing
(Duurzame) effecten van conflictoplossing via rechterlijke interventies.
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Zeta-values of arithmetic schemes at negative integers and Weil-étale cohomology
This work is dedicated to interpreting in cohomological terms the special values of zeta functions of arithmetic schemes.
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Shy parent, shy child?
Delineating psychophysiological endophenotypes of social anxiety disorder
- English Language Assessment
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Mesoporous silica nanoparticle-based protein delivery systems for biomedical applications
Promotor: A. Kros
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Galactic substructures as tracers of dark matter and stellar evolution
One of the most important puzzles in modern astrophysics is the nature of dark matter.