Promotores: Prof.dr. F.S. de Boer, Prof.dr. J.J.M.M. Rutten (Radboud Universiteit Nijmegen)

This dissertation explores how Large Language Models (LLMs) can effectively and responsibly contribute to complex decision-making processes. By combining AI and human intelligence, Hybrid Intelligence (HI) emerges, allowing the strengths of both humans and machines to be utilized.

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).

In this thesis, deep learning is studied from a statistical perspective. Convergence rates for the worst case risk bounds of neural network estimators are obtained in the classification, density estimation and linear regression model.

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

Promotor: Prof. dr. Arnold Tukker & Prof. dr. René Kemp (Maastricht University)

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri

Stellar feedback is a crucial ingredient in the evolution of galaxies.

Promotor: S.M. Verduyn Lunel

Promotores: Prof.dr. H Lenstra, Prof.dr. A Facchini (Padova University)

Promotor: T.H. Oosterkamp

We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

The field of science communication is very broad. Below is a list of organisations where SCS students can fulfill internships or where alumni have found jobs.

Promotores: Prof.dr. S.J. Edixhoven, Prof.dr. E. Ullmo (University Paris-Sud)

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…

Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

Promotor: K.E. Schalm, Co-promotor: S.S. Lee

Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.

AI Labs zijn samenwerkingen van de Universiteit Leiden met externe partner zoals bedrijven, overheidsinstellingen en andere universiteit op het gebied van kunstmatige intelligentie. De Faculteit voor Wis-en Natuurkunde is uniek gesitueerd op het grootste Bioscience Park van Nederlands, en ligt direct…

Quantum hardware comes with a different computing paradigm and new ways to tackle applications. Much effort has to be put into understanding how to leverage this technology to give real-world advantages in areas of interest for industries such as combinatorial optimization or machine learning.

Promotor: Prof.dr. J.M. van Ruitenbeek, Prof.dr. R.M. Tromp

An Active Galactic Nucleus (AGN) is a highly luminous region at the center of a galaxy, powered by the accretion into a supermassive black hole and emitting energy from radio waves to gamma rays, often outshining the host galaxy.

Heart failure is a major health care problem with high mortality.

De Faculteit Governance and Global Affairs (FGGA) richt zicht op onderzoek naar maatschappelijke en governancevraagstukken zoals terrorisme, organisatie van het openbaar bestuur, klimaatverandering en economische crises. Hedendaagse onderwerpen worden zowel vanuit een bestuurskundig, politicologisch,…

The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.

We investigate the buildup of galaxies from various vantage points. The first two chapters focus on the stellar content of galaxies, especially the distribution of stellar masses at birth and potential variations therein in various galactic environments.

Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska

Promotor: Prof.dr. W.J.G.M. Peijnenburg

Promotor: G.R. de Snoo

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

Carbohydrates, or sugars, are the most diverse and most abundant biomolecules known. However, the isolation of carbohydrate samples in sufficient amounts and purity is often impractical or even impossible, so the chemical synthesis of glycosides becomes relevant. The glycosylation reaction, in which…

Promotores: Prof.dr. J.N. Kok, Prof.dr. M.R.V. Chaudron (Chalmers Univ., Sweden)

Cardiovascular disease is the leading cause of death worldwide.

When a star gets too close to a supermassive black hole, it is torn apart by strong tidal forces in a tidal disruption event (TDE).

Promotores: Prof.dr. B.R. Katzy, Prof.dr. K. Sailer (Munich University)

Promotor: Prof.dr. J.N. Kok, Co-promotor: A.J. Knobbe

The redox-conversion reaction of metal-disulfide and metal-thiolate complexes are important, as they may shed light on electron-transfer reactions that often occur in Nature.

Promotor: Prof.dr. T. Hankemeier

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

The elementary excitations of magnets are called spin waves, and their corresponding quasi-particles are known as magnons. The rapidly growing field of Magnonics aims at using them as information carriers in a new generation of electronic devices, (almost) free of electric currents.

The mycorrhizal symbiosis is among the most widespread species interactions on Earth⁠. This thesis focuses on orchid mycorrhiza, a unique mycorrhizal type that has caught scientists’ attention for centuries⁠.

Mycoheterotrophy is a particular mode of life in which plants obtain carbohydrates from their associated fungal partners, instead of by using photosynthesis.

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.