554 zoekresultaten voor “novel prins” in de Publieke website
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Franciskus PrinsFaculteit Geneeskunde
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Brenda Prins
Bestuursbureau
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Geert PrinsFaculteit der Geesteswetenschappen
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Janine PrinsFaculteit der Sociale Wetenschappen
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Ruth PrinsFaculteit Governance and Global Affairs
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Jan-Bas PrinsFaculteit Geneeskunde
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Monique Jongman-PrinsFaculteit Governance and Global Affairs
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Ingrid Wilmot-PrinsFaculteit Rechtsgeleerdheid
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Gea Hakker-PrinsFaculteit der Geesteswetenschappen
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Novel Mechanism and Signaling Pathways in Angiogenesis
Promotie
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Identification of novel targets in prostate cancer progression
Promotor: B. van de Water, Co-promotor: E.H.J. Danen
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Probing quantum materials with novel scanning tunneling microscopy techniques
This thesis described the development of novel scanning tunneling microscopy techniques to investigate strongly correlated electronic states in quantum matter.
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Exploring the mechanisms of metastatic onset for novel treatment strategies
This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.
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Novel regulators of prostate cancer stem cells and tumor aggressiveness
Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm
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Immunity in atherosclerosis: novel assays, biomarkers and therapeutic approaches
Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.
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Novel chemical tools for target validation in neuroinflammation
Stelt
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Novel pharmacometric techniques to quantify the pharmacodynamics of analgesics
The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.
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Novel analytical approaches to characterize particles in biopharmaceuticals
Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).
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A novel supramolecular system for membrane fusion and biosensing
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Novel target engagement biomarkers for better drug candidates
M van der Stelt
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Supramolecular peptide amphiphile nanoparticles as a novel allergy vaccine
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Novel Protecting Group Strategies in the Synthesis of Oligosaccharides
The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.
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Novel approaches for direct exoplanet imaging: theory, simulations and experiments
The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.
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Novel Immune Cell-Based Therapies for Atherosclerosis
Promotor: Prof.dr. J. Kuiper
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Supramolecular peptide amphiphile nanoparticles as a novel allergy vaccine platform
Bet v1, the major allergen in birch pollen, is one of the main causes of allergies such as asthma and rhino-conjunctivitis. It is the main cause of birch pollen allergy in humans.
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Novel detectors and algorithms for electron nano-crystallography
Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel
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Modelling the interactions of advanced micro- and nanoparticles with novel entities
Novel entities may pose risks to humans and the environment. The small particle size and relatively large surface area of micro- and nanoparticles (MNPs) make them capable of adsorbing other novel entities, leading to the formation of aggregated contamination.
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Witnessing the Process of Bacterial Cell Death: Novel Antimicrobials and Their Mechanisms of Action
This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…
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The road to insurmountability: Novel avenues to better target CC Chemokine receptors
This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.
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Manipulating carbon nanotubes Towards the application as novel field emission sources
Promotores: T.H. Oosterkamp, N. de Jonge
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Knowledge discovery from patient forums: gaining novel medical insights from patient experiences
Patients share valuable advice and experiences with their peers in online patient discussion groups.
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Prediction of spatial-temporal brain drug distribution with a novel mathematical model
A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.
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Discovery of novel Antibiotics from Actinomycetes by Integrated Metabolomics & Genomics Approaches
Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…
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Discovery of novel inhibitors to investigate diacylglycerol lipases and α/β hydrolase domain 16A
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Visualizing strongly-correlated electrons with a novel scanning tunneling microscope
Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.
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Genomics driven metabolomics novel strategies for the discovery and identification of secondary metabolites
Promotor: T. Hankemeier, Co-promotor: R.J. Vreeken
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Applying autonomous biomolecular cascade reactions to synthesize novel hybrid nucleic acid-graft copolymeric materials
Kieltyka
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Zebrafish xenograft model: identification of novel mechanisms driving prostate cancer metastasis
Prostate cancer (PCa) is one of the most prevalent cancer in males.
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Novel formulations and delivery strategies for inactivated polio vaccines : new routes with benefits
This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.
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Exploring novel regulators and enzymes in salicylic acid-mediated plant defense
Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.
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Novel factors modulating AGC kinase signaling-controlled polar auxin transport
The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.
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A novel formulation for skin barrier repair : from ex vivo assessment towards clinical studies
The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.
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NL-Academics' role identities and role transitions at new universities: Novel researcher roles alongside current teacher roles
[Tekst volgt]
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‘Non-Istanbulites’ of Istanbul: Quest for a place in Istanbul in the Turkish novel since the 1960s
Dit onderzoek richt zich op een historisch-sociale analyse van een geselecteerd corpus van romans uit de moderne Turkse literatuur die het thema delen van de migratie van Anatolische steden en dorpen naar Istanbul en de strijd van immigranten in deze stad tegen verschillende uitsluitingsmechanismen.
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Combining classic and novel tools in the study of Historical Collections of Chinese Materia Medica in the Netherlands
Chinese materia medica (CMM), comprising a diverse array of natural substances from plants, animals, and minerals, has been integral to Traditional Chinese Medicine (TCM) throughout history. This study investigates the dynamic evolution of CMM, noting shifts in species for improved therapeutic effects…
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Novel role of the AT-HOOK MOTIF NUCLEAR LOCALIZED 15 gene in Arabidopsis meristem activity and longevity
Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.
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sunlight with plants and microorganisms: imaging and metabolomics with novel microcoil and cryoprobe at ultrahigh magnetic field
Huub de Groot
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Novel system-inspired model-based quantum machine learning algorithm for prediction and generation of High-Energy Physics data
De huidige en toekomstige quantumcomputers vormen dezelfde uitdaging als de laser in zijn begindagen. In theorie werd voorspeld dat de laser een bron van zeer speciaal, zeer krachtig licht zou zijn. Maar in die tijd waren er geen duidelijke toepassingen voor. Critici van het idee noemden het een probleem…
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Ruth Prins over ondergedoken burgemeester Haarlem
De Haarlemse burgemeester Jos Wienen zit ondergedoken vanwege bedreigingen uit onbekende hoek. Onderzoeker Ruth Prins sprak erover in het televisieprogramma Na het nieuws.